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dwg deformed wings [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31265, updated on 27-Aug-2024

Summary

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Official Symbol
dwgprovided by FlyBase
Official Full Name
deformed wingsprovided by FlyBase
Primary source
FLYBASE:FBgn0000520
Locus tag
Dmel_CG2711
See related
AllianceGenome:FB:FBgn0000520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2711; CG2714; Dmel\CG2711; Dwg; DWG; EG:95B7.6; l(1)3Be; l(1)zw5; Sbp; SBP; ves; zw-5; Zw-5; ZW-5; zw5; Zw5; ZW5
Summary
Enables chromatin insulator sequence binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Located in nucleus. Colocalizes with chromatin. Is expressed in organism. Orthologous to human MZF1 (myeloid zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
3B3-3B3; 1-1.5 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2727698..2730042)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2621731..2624075)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene female sterile (1) Young arrest Neighboring gene vilya Neighboring gene tiny tim 50 Neighboring gene uncharacterized protein Neighboring gene cramped

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Architectural proteins Pita, Zw5,and ZIPIC contain homodimerization domain and support specific long-range interactions in Drosophila. Zolotarev N, et al. Nucleic Acids Res, 2016 Sep 6. PMID 27137890, Free PMC Article
  2. Protein:protein interactions and the pairing of boundary elements in vivo. Blanton J, et al. Genes Dev, 2003 Mar 1. PMID 12629048, Free PMC Article
  3. [Translation elongation factor EF1α1 interacts with ZAD domains of transcription factors from Drosophila melanogaster]. Zolotarev NA, et al. Mol Biol (Mosk), 2016 Nov-Dec. PMID 28064318
  4. Deletions induced in the white and vermilion genes of Drosophila melanogaster by the antitumor drug cis-dichlorodiammineplatinum(II). Cizeau J, et al. Mutat Res, 1994 Nov 1. PMID 7526172
  5. Chromatin insulators and long-distance interactions in Drosophila. Kyrchanova O, et al. FEBS Lett, 2014 Jan 3. PMID 24211836

See all (111) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin insulator sequence binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
deformed wings
Names
CG2711-PA
deformed wing
dwg-PA
scs binding protein
scs-binding protein
vestigium
zeste white 5
zeste-white 5
zeste-white5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2727698..2730042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057990.4 → NP_477338.3  deformed wings [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477338.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RB8, Q9W4V9
    Related
    FBpp0070465
    Conserved Domains (4) summary
    smart00868
    Location:14 → 91
    zf-AD; Zinc-finger associated domain (zf-AD)
    COG5048
    Location:387 → 523
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:363 → 383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:403 → 426
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U9D0 Q9U9D0
Q9W4V9 Q9W4V9

Gene LinkOut

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