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Trnt1 tRNA nucleotidyl transferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312616, updated on 28-Oct-2024

Summary

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Official Symbol
Trnt1provided by RGD
Official Full Name
tRNA nucleotidyl transferase 1provided by RGD
Primary source
RGD:1308857
See related
EnsemblRapid:ENSRNOG00000006432 AllianceGenome:RGD:1308857
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable CCACCA tRNA nucleotidyltransferase activity; protein homodimerization activity; and tRNA binding activity. Predicted to be involved in rescue of stalled ribosome and tRNA metabolic process. Predicted to be active in cytosol; mitochondrion; and nucleus. Human ortholog(s) of this gene implicated in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Orthologous to human TRNT1 (tRNA nucleotidyl transferase 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Heart (RPKM 200.8), Thymus (RPKM 195.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trnt1 in Genome Data Viewer
Location:
4q41
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (141236937..141259700)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (139681115..139703611)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (138855497..138869217)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene contactin 4 Neighboring gene uncharacterized LOC120102502 Neighboring gene U6 spliceosomal RNA Neighboring gene interleukin 5 receptor subunit alpha Neighboring gene cereblon Neighboring gene uncharacterized LOC134486621 Neighboring gene ALG11, alpha-1,2-mannosyltransferase, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD). Chakraborty PK, et al. Blood, 2014 Oct 30. PMID 25193871, Free PMC Article
  2. Identification and characterization of mammalian mitochondrial tRNA nucleotidyltransferases. Nagaike T, et al. J Biol Chem, 2001 Oct 26. PMID 11504732
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124985

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CCA tRNA nucleotidyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables CCACCA tRNA nucleotidyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial tRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA 3'-terminal CCA addition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA 3'-terminal CCA addition ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA surveillance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CCA tRNA nucleotidyltransferase 1, mitochondrial
Names
tRNA nucleotidyl transferase, CCA-adding, 1
tRNA-nucleotidyltransferase 1, mitochondrial
NP_001019432.1
XP_008761414.1
XP_008761415.1
XP_038963555.1
XP_063142154.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024261.3 → NP_001019432.1  CCA tRNA nucleotidyltransferase 1, mitochondrial

    See identical proteins and their annotated locations for NP_001019432.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    F7EZK1, Q4VBH2
    Conserved Domains (1) summary
    COG0617
    Location:40 → 417
    PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    141236937..141259700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286084.1 → XP_063142154.1  CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZPS5

  2. XM_039107627.2 → XP_038963555.1  CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X2

    UniProtKB/TrEMBL
    F7EZK1, Q4VBH2
    Related
    ENSRNOP00000080320.2, ENSRNOT00000119654.2
    Conserved Domains (1) summary
    COG0617
    Location:40 → 417
    PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]

  3. XM_008763192.4 → XP_008761414.1  CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_008761414.1

    UniProtKB/TrEMBL
    F7EZK1, Q4VBH2
    Conserved Domains (1) summary
    COG0617
    Location:40 → 417
    PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]

  4. XM_008763193.4 → XP_008761415.1  CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_008761415.1

    UniProtKB/TrEMBL
    F7EZK1, Q4VBH2
    Conserved Domains (1) summary
    COG0617
    Location:40 → 417
    PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]
Nucleotide Protein Strain
Heading Accession and Version

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