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eIF3g1 eukaryotic translation initiation factor 3 subunit g1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31243, updated on 2-Nov-2024

Summary

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Official Symbol
eIF3g1provided by FlyBase
Official Full Name
eukaryotic translation initiation factor 3 subunit g1provided by FlyBase
Primary source
FLYBASE:FBgn0029629
Locus tag
Dmel_CG8636
See related
AllianceGenome:FB:FBgn0029629
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg8636; CG8636; Dmel\CG8636; eIF s4; eIF-3; eIF-3ga; eIF3-S4; eIF3g; eIF3G1; eIF3ga
Summary
Predicted to enable mRNA binding activity and translation initiation factor activity. Involved in mitotic cell cycle. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval muscle cell; and mesoderm. Orthologous to human EIF3G (eukaryotic translation initiation factor 3 subunit G). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See eIF3g1 in Genome Data Viewer
Location:
3A7-3A7; 1-1 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2609247..2610336, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2503280..2504369, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Kinesin-like protein at 3A Neighboring gene Zeste-white 10 Neighboring gene SET and MYND domain containing, class 3 Neighboring gene Tetraspanin 3A Neighboring gene seipin Neighboring gene brivido-3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dissecting the roles of EIF4G homologs reveals DAP5 as a modifier of CGG repeat-associated toxicity in a Drosophila model of FXTAS. Malik I, et al. Neurobiol Dis, 2023 Aug. PMID 37352983, Free PMC Article
  2. Identification of Novel Regulators of the JAK/STAT Signaling Pathway that Control Border Cell Migration in the Drosophila Ovary. Saadin A, et al. G3 (Bethesda), 2016 Jul 7. PMID 27175018, Free PMC Article
  3. A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing. Lu YX, et al. Elife, 2021 May 14. PMID 33988501, Free PMC Article
  4. SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity. Malik I, et al. EMBO Mol Med, 2021 Nov 8. PMID 34542927, Free PMC Article
  5. Phenotypic suppression of the Drosophila mitochondrial disease-like mutant tko(25t) by duplication of the mutant gene in its natural chromosomal context. Kemppainen E, et al. Mitochondrion, 2009 Sep. PMID 19616644

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic cell cycle HMP PubMed 
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit g1
Names
CG8636-PA
eIF3g paralogue a
eIF3g1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2609247..2610336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_130655.2 → NP_570011.1  eukaryotic translation initiation factor 3 subunit g1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_570011.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W4X7
    Related
    FBpp0070430
    Conserved Domains (3) summary
    COG0724
    Location:161 → 269
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12408
    Location:189 → 265
    RRM_eIF3G_like; RNA recognition motif in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins
    pfam12353
    Location:30 → 140
    eIF3g; Eukaryotic translation initiation factor 3 subunit G
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W4X7.1 Q9W4X7

Gene LinkOut

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