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Dennd11 DENN domain containing 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312270, updated on 2-Nov-2024

Summary

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Official Symbol
Dennd11provided by RGD
Official Full Name
DENN domain containing 11provided by RGD
Primary source
RGD:1563986
See related
EnsemblRapid:ENSRNOG00000011854 AllianceGenome:RGD:1563986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LCHN; RGD1563986
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in cytoplasm. Orthologous to human DENND11 (DENN domain containing 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 125.7), Kidney (RPKM 38.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dennd11 in Genome Data Viewer
Location:
4q23
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (70163869..70232731, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (69197161..69266013, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (68569308..68597626, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 178B Neighboring gene uncharacterized LOC102555151 Neighboring gene acylglycerol kinase Neighboring gene WEE2 oocyte meiosis inhibiting kinase Neighboring gene taste receptor, type 2, member 137 Neighboring gene taste receptor, type 2, member 108 Neighboring gene single stranded DNA binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of LCHN: a novel factor induced by transient global ischemia in the adult rat hippocampus. Zhang G, et al. J Neurochem, 2007 Apr. PMID 17394467
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DENN domain-containing protein 11
Names
protein LCHN

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044701.2 → NP_001038166.1  DENN domain-containing protein 11

    See identical proteins and their annotated locations for NP_001038166.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q0PGW2
    UniProtKB/TrEMBL
    A6IEX0
    Related
    ENSRNOP00000015921.5, ENSRNOT00000015921.8
    Conserved Domains (1) summary
    pfam09804
    Location:80 → 346
    DUF2347; Uncharacterized conserved protein (DUF2347)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    70163869..70232731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107528.2 → XP_038963456.1  DENN domain-containing protein 11 isoform X2

    Conserved Domains (1) summary
    pfam09804
    Location:1 → 255
    DUF2347; Uncharacterized conserved protein (DUF2347)

  2. XM_006236361.5 → XP_006236423.2  DENN domain-containing protein 11 isoform X1

    UniProtKB/Swiss-Prot
    Q0PGW2
    UniProtKB/TrEMBL
    A6IEX0
    Conserved Domains (1) summary
    pfam09804
    Location:80 → 346
    DUF2347; Uncharacterized conserved protein (DUF2347)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0PGW2.1 GenPept UniProtKB/Swiss-Prot:Q0PGW2

Gene LinkOut

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