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gt giant [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31227, updated on 18-Sep-2024

Summary

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Official Symbol
gtprovided by FlyBase
Official Full Name
giantprovided by FlyBase
Primary source
FLYBASE:FBgn0001150
Locus tag
Dmel_CG7952
See related
AllianceGenome:FB:FBgn0001150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7952; Dm-gt; DM17; Dmel\CG7952; EG:BACH7M4.5; Giant; GIAN_DROME; Gt; GT; l(1)3Aa; l(1)giant
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including axon guidance; regionalization; and ring gland development. Located in nucleus. Is expressed in several structures, including ectoderm; ectoderm anlage; extended germ band embryo; head segment; and presumptive embryonic/larval nervous system. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
3A3-3A3; 1-1 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2427113..2428967, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2321146..2323000, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene technical knockout Neighboring gene brother of ihog Neighboring gene zeste

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Polycomb-group recruitment to a Drosophila target gene is the default state that is inhibited by a transcriptional activator. Ghotbi E, et al. Sci Adv, 2021 Jul. PMID 34272248, Free PMC Article
  2. DNA-binding specificity of the PAR basic leucine zipper protein VBP partially overlaps those of the C/EBP and CREB/ATF families and is influenced by domains that flank the core basic region. Haas NB, et al. Mol Cell Biol, 1995 Apr. PMID 7891686, Free PMC Article
  3. Analysis of metamorphosis in Drosophila melanogaster: characterization of giant, an ecdysteroid-deficient mutant. Schwartz MB, et al. Dev Biol, 1984 May. PMID 6425099
  4. Region-specific defects in l(1)giant embryos of Drosophila melanogaster. Petschek JP, et al. Dev Biol, 1987 Jan. PMID 3098602
  5. Mitochondria as environments for the nuclear genome in Drosophila: mitonuclear G×G×E. Rand DM, et al. J Hered, 2022 Feb 17. PMID 34964900, Free PMC Article

See all (476) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exploring a Drosophila Transcription Factor Interaction Network to Identify Cis-Regulatory Modules.
    Title: Exploring a Drosophila Transcription Factor Interaction Network to Identify Cis-Regulatory Modules.
  2. there are two phases of transcriptional regulation for the gap gene giant in Drosophila
    Title: A quantitative validated model reveals two phases of transcriptional regulation for the gap gene giant in Drosophila.
  3. two polycomb response elements-containing regions at the Polycomb-group proteins target gene, giant, one at the promoter, and another approximately 6 kb upstream.
    Title: Mapping polycomb response elements at the Drosophilla melanogaster giant locus.
  4. Results showed Gt repression roles in the regulation of two groups of partially overlapping stripes and that Gt morphogen activity is part of the mechanism responsible for the differential positioning of these stripes borders.
    Title: Investigating giant (Gt) repression in the formation of partially overlapping pair-rule stripes.
  5. gt likely controls ecdysone production indirectly by contributing the peptidergic phenotype of the PTTH-producing neurons in the embryo
    Title: The Drosophila gap gene giant regulates ecdysone production through specification of the PTTH-producing neurons.
  6. The Drosophila gap gene giant has an anterior segment identity function mediated through disconnected and teashirt.
    Title: The Drosophila gap gene giant has an anterior segment identity function mediated through disconnected and teashirt.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
involved_in posterior head segmentation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in ring gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in salivary gland development TAS
Traceable Author Statement
more info
 PubMed 
involved_in specification of segmental identity, labial segment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in zygotic determination of anterior/posterior axis, embryo NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in zygotic determination of anterior/posterior axis, embryo TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
giant
Names
CG7952-PB
gt-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2427113..2428967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080310.3 → NP_525049.1  giant [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525049.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9EQS3, P39572, Q7YU39, Q9V3N3
    Related
    FBpp0070444
    Conserved Domains (1) summary
    cd14695
    Location:383 → 440
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39572.2 P39572

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Chemical Information
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