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Klhdc10 kelch domain containing 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312199, updated on 2-Nov-2024

Summary

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Official Symbol
Klhdc10provided by RGD
Official Full Name
kelch domain containing 10provided by RGD
Primary source
RGD:1309792
See related
EnsemblRapid:ENSRNOG00000010267 AllianceGenome:RGD:1309792
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309792
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in positive regulation of stress-activated MAPK cascade; rescue of stalled ribosome; and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be located in nucleoplasm. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHDC10 (kelch domain containing 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 273.3), Brain (RPKM 233.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Klhdc10 in Genome Data Viewer
Location:
4q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (59988710..60046518)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (59021300..59079118)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (57715982..57773800)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA32 Neighboring gene zinc finger, C3HC-type containing 1 Neighboring gene uncharacterized LOC134486570 Neighboring gene uncharacterized LOC108350685 Neighboring gene transmembrane protein 209

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of stress-activated MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in rescue of stalled ribosome IEA
Inferred from Electronic Annotation
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul2-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kelch domain-containing protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017456.1 → NP_001017456.1  kelch domain-containing protein 10

    See identical proteins and their annotated locations for NP_001017456.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085351
    UniProtKB/Swiss-Prot
    Q5U3Y0
    UniProtKB/TrEMBL
    A0A8I5ZRC5, A6IEG0
    Related
    ENSRNOP00000038586.4, ENSRNOT00000034429.6
    Conserved Domains (4) summary
    PLN02153
    Location:107 → 270
    PLN02153; epithiospecifier protein
    PRK14131
    Location:56 → 139
    PRK14131; N-acetylneuraminate epimerase
    sd00038
    Location:176 → 224
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:283 → 329
    Kelch_1; Kelch motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    59988710..60046518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236201.5 → XP_006236263.1  kelch domain-containing protein 10 isoform X1

    See identical proteins and their annotated locations for XP_006236263.1

    UniProtKB/TrEMBL
    A0A0G2KB15, A0A8I5ZRC5
    Related
    ENSRNOP00000106559.1, ENSRNOT00000096895.2
    Conserved Domains (4) summary
    PLN02153
    Location:136 → 299
    PLN02153; epithiospecifier protein
    PRK14131
    Location:85 → 168
    PRK14131; N-acetylneuraminate epimerase
    sd00038
    Location:205 → 253
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:312 → 358
    Kelch_1; Kelch motif
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U3Y0.1 GenPept UniProtKB/Swiss-Prot:Q5U3Y0

Gene LinkOut

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