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pcx pecanex [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31204, updated on 2-Nov-2024

Summary

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Official Symbol
pcxprovided by FlyBase
Official Full Name
pecanexprovided by FlyBase
Primary source
FLYBASE:FBgn0003048
Locus tag
Dmel_CG3443
See related
AllianceGenome:FB:FBgn0003048
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3443; Dmel\CG3443; DMPCX; EG:30B8.4; fs(1)12-1012; fs(1)12-1743; fs(1)12-2135; fs(1)12-3014; fs(1)12-3102; fs(1)12-4169; fs(1)14-1153; fs(1)14-567; fs(1)A387; fs(1)M10; fs(1)pcx; mel(1)R; mel(1)R1
Summary
Involved in endoplasmic reticulum organization. Located in endoplasmic reticulum. Is expressed in organism. Orthologous to several human genes including PCNX3 (pecanex 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See pcx in Genome Data Viewer
Location:
2F1-2F1; 1-0.9 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2225296..2238045)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2119329..2132078)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Vinculin Neighboring gene uncharacterized protein Neighboring gene kurz Neighboring gene female sterile (1) K10 Neighboring gene Odorant receptor 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differentiation in vitro of neural precursor cells from normal and Pecanex mutant Drosophila embryos. LaBonne SG, et al. J Neurogenet, 1989 May. PMID 2500508
  2. A mammalian homologue of a transcript from the Drosophila pecanex locus. Gilbert TL, et al. J Neurogenet, 1992 Sep. PMID 1460533
  3. Maternally influenced embryonic lethality: allele specific genetic rescue at a female fertility locus in Drosophila melanogaster. Romans P, et al. Can J Genet Cytol, 1976 Dec. PMID 828515
  4. Molecular genetics of pecanex, a maternal-effect neurogenic locus of Drosophila melanogaster that potentially encodes a large transmembrane protein. LaBonne SG, et al. Dev Biol, 1989 Nov. PMID 2478400
  5. Partial rescue of embryos from two maternal-effect neurogenic mutants by transplantation of wild-type ooplasm. LaBonne SG, et al. Dev Biol, 1985 Jul. PMID 4007265

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic screens study identified dominant modifiers of the cold-sensitive lethality associated with a pcx mutation condition.
    Title: Insight into Notch Signaling Steps That Involve pecanex from Dominant-Modifier Screens in Drosophila.
  2. It was shown that pecanex is a component of the Notch-signaling pathway. Pecanex was required upstream of the membrane-tethered and the nuclear forms of activated Notch protein.
    Title: Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in endoplasmic reticulum organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pecanex
Names
CG3443-PC
CG3443-PE
CG3443-PF
pcx-PC
pcx-PE
pcx-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2225296..2238045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272254.2 → NP_001259183.2  pecanex, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259183.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGU2
    Conserved Domains (2) summary
    pfam05041
    Location:2523 → 2746
    Pecanex_C; Pecanex protein (C-terminus)
    pfam15847
    Location:2779 → 2842
    Loricrin; Major keratinocyte cell envelope protein

  2. NM_001272253.1 → NP_001259182.1  pecanex, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259182.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46074, P18490, Q95TI6, Q9W506
    UniProtKB/TrEMBL
    M9PGB7
    Conserved Domains (2) summary
    pfam05041
    Location:2519 → 2742
    Pecanex_C; Pecanex protein (C-terminus)
    pfam15847
    Location:2775 → 2838
    Loricrin; Major keratinocyte cell envelope protein

  3. NM_080306.4 → NP_525045.3  pecanex, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525045.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46074, P18490, Q95TI6, Q9W506
    UniProtKB/TrEMBL
    M9PGB7
    Conserved Domains (2) summary
    pfam05041
    Location:2519 → 2742
    Pecanex_C; Pecanex protein (C-terminus)
    pfam15847
    Location:2775 → 2838
    Loricrin; Major keratinocyte cell envelope protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PGB7 M9PGB7
M9PGU2 M9PGU2
P18490.4 P18490

Gene LinkOut

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