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bcn92 bcn92 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31186, updated on 18-Sep-2024

Summary

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Official Symbol
bcn92provided by FlyBase
Official Full Name
bcn92provided by FlyBase
Primary source
FLYBASE:FBgn0013432
Locus tag
Dmel_CG3717
See related
AllianceGenome:FB:FBgn0013432
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE57896; Bcn92; CG3717; Dmel\CG3717; EG:87B1.6; Isd11; NEST:bs15a04
Summary
Involved in iron-sulfur cluster assembly. Located in mitochondrion. Part of L-cysteine desulfurase complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 19. Orthologous to human LYRM4 (LYR motif containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See bcn92 in Genome Data Viewer
Location:
2D4-2D4; 1-0.6 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2148463..2149647, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2042496..2043680, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene polyhomeotic proximal Neighboring gene D-2-hydroxyglutaric acid dehydrogenase Neighboring gene Phosphogluconate dehydrogenase Neighboring gene wings apart-like Neighboring gene Cytochrome P450 4d1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular characterization of the breakpoints of an inversion fixed between Drosophila melanogaster and D. subobscura. Cirera S, et al. Genetics, 1995 Jan. PMID 7705632, Free PMC Article
  2. orsai, the Drosophila homolog of human ETFRF1, links lipid catabolism to growth control. Fernandez-Acosta M, et al. BMC Biol, 2022 Oct 21. PMID 36266680, Free PMC Article
  3. Linking global histone acetylation to the transcription enhancement of X-chromosomal genes in Drosophila males. Smith ER, et al. J Biol Chem, 2001 Aug 24. PMID 11445559
  4. Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster. Vernì F, et al. Genetics, 2000 Apr. PMID 10747063, Free PMC Article
  5. Loss of the Polycomb group gene polyhomeotic induces non-autonomous cell overproliferation. Feng S, et al. EMBO Rep, 2011 Feb. PMID 21164514, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron-sulfur cluster assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of L-cysteine desulfurase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial [2Fe-2S] assembly complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in mitochondrial matrix IC
Inferred by Curator
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bcn92
Names
CG3717-PA
bcn92-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2148463..2149647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057711.3 → NP_477059.2  bcn92 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477059.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46098, Q9U5X3
    UniProtKB/TrEMBL
    A0A0F6QCW0
    Related
    FBpp0070415
    Conserved Domains (1) summary
    pfam13232
    Location:5 → 65
    Complex1_LYR_1; Complex1_LYR-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O46098.1 O46098

Gene LinkOut

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