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Tpx2 TPX2, microtubule nucleation factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 311546, updated on 2-Nov-2024

Summary

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Official Symbol
Tpx2provided by RGD
Official Full Name
TPX2, microtubule nucleation factorprovided by RGD
Primary source
RGD:1311894
See related
EnsemblRapid:ENSRNOG00000008165 AllianceGenome:RGD:1311894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable importin-alpha family protein binding activity; molecular adaptor activity; and protein kinase binding activity. Predicted to be involved in activation of protein kinase activity; microtubule cytoskeleton organization; and regulation of microtubule cytoskeleton organization. Predicted to be located in several cellular components, including axon hillock; intercellular bridge; and spindle. Predicted to be active in spindle. Orthologous to human TPX2 (TPX2 microtubule nucleation factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 212.7), Spleen (RPKM 144.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tpx2 in Genome Data Viewer
Location:
3q41
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (161778709..161820941)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (141318428..141360684)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (148327965..148370187)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486188 Neighboring gene cytochrome c oxidase subunit 4i2 Neighboring gene Bcl2-like 1 Neighboring gene ribosomal protein S2, pseudogene 43 Neighboring gene small nucleolar RNA U109 Neighboring gene uncharacterized LOC102553350 Neighboring gene myosin light chain kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2. Zhao B, et al. Protein Sci, 2008 Oct. PMID 18662907, Free PMC Article
  2. A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2. Bibby RA, et al. J Biol Chem, 2009 Nov 27. PMID 19801554, Free PMC Article
  3. Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A. Bird AW, et al. J Cell Biol, 2008 Jul 28. PMID 18663142, Free PMC Article
  4. Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Bayliss R, et al. Mol Cell, 2003 Oct. PMID 14580337
  5. Complementary activities of TPX2 and chTOG constitute an efficient importin-regulated microtubule nucleation module. Roostalu J, et al. Nat Cell Biol, 2015 Nov. PMID 26414402, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables importin-alpha family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon hillock ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
targeting protein for Xklp2
Names
TPX2, microtubule-associated protein homolog
TPX2, microtubule-associated, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107790.3 → NP_001101260.1  targeting protein for Xklp2 isoform a

    See identical proteins and their annotated locations for NP_001101260.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6ARV3, A6KHR8, D3ZA78
    Conserved Domains (3) summary
    pfam09041
    Location:1 → 68
    Aurora-A_bind; Aurora-A binding
    pfam06886
    Location:658 → 738
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam12214
    Location:365 → 487
    TPX2_importin; Cell cycle regulated microtubule associated protein

  2. NM_001434079.1 → NP_001421008.1  targeting protein for Xklp2 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  3. NM_001434080.1 → NP_001421009.1  targeting protein for Xklp2 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  4. NM_001434081.1 → NP_001421010.1  targeting protein for Xklp2 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  5. NM_001434082.1 → NP_001421011.1  targeting protein for Xklp2 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  6. NM_001434083.1 → NP_001421012.1  targeting protein for Xklp2 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  7. NM_001434084.1 → NP_001421013.1  targeting protein for Xklp2 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    161778709..161820941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235273.5 → XP_006235335.1  targeting protein for Xklp2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ARV3, A6KHR8, D3ZA78
    Conserved Domains (3) summary
    pfam09041
    Location:1 → 68
    Aurora-A_bind; Aurora-A binding
    pfam06886
    Location:658 → 738
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam12214
    Location:365 → 487
    TPX2_importin; Cell cycle regulated microtubule associated protein

  2. XM_039105064.2 → XP_038960992.1  targeting protein for Xklp2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JT92, A0A8I6ARV3
    Related
    ENSRNOP00000097456.2, ENSRNOT00000104440.2
    Conserved Domains (3) summary
    pfam09041
    Location:1 → 68
    Aurora-A_bind; Aurora-A binding
    pfam06886
    Location:651 → 731
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam12214
    Location:365 → 487
    TPX2_importin; Cell cycle regulated microtubule associated protein

  3. XM_006235270.5 → XP_006235332.1  targeting protein for Xklp2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ARV3, A6KHR8, D3ZA78
    Conserved Domains (3) summary
    pfam09041
    Location:1 → 68
    Aurora-A_bind; Aurora-A binding
    pfam06886
    Location:658 → 738
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam12214
    Location:365 → 487
    TPX2_importin; Cell cycle regulated microtubule associated protein

  4. XM_006235274.5 → XP_006235336.1  targeting protein for Xklp2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JT92, A0A8I6ARV3
    Related
    ENSRNOP00000068619.2, ENSRNOT00000088481.3
    Conserved Domains (3) summary
    pfam09041
    Location:1 → 68
    Aurora-A_bind; Aurora-A binding
    pfam06886
    Location:651 → 731
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam12214
    Location:365 → 487
    TPX2_importin; Cell cycle regulated microtubule associated protein

  5. XM_006235272.5 → XP_006235334.1  targeting protein for Xklp2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ARV3, A6KHR8, D3ZA78
    Conserved Domains (3) summary
    pfam09041
    Location:1 → 68
    Aurora-A_bind; Aurora-A binding
    pfam06886
    Location:658 → 738
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam12214
    Location:365 → 487
    TPX2_importin; Cell cycle regulated microtubule associated protein

  6. XM_063283825.1 → XP_063139895.1  targeting protein for Xklp2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JT92

  7. XM_039105059.2 → XP_038960987.1  targeting protein for Xklp2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ARV3, A6KHR8, D3ZA78
    Conserved Domains (3) summary
    pfam09041
    Location:1 → 68
    Aurora-A_bind; Aurora-A binding
    pfam06886
    Location:658 → 738
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam12214
    Location:365 → 487
    TPX2_importin; Cell cycle regulated microtubule associated protein

  8. XM_063283824.1 → XP_063139894.1  targeting protein for Xklp2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JT92

  9. XM_039105061.2 → XP_038960989.1  targeting protein for Xklp2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ARV3, A6KHR8, D3ZA78
    Conserved Domains (3) summary
    pfam09041
    Location:1 → 68
    Aurora-A_bind; Aurora-A binding
    pfam06886
    Location:658 → 738
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam12214
    Location:365 → 487
    TPX2_importin; Cell cycle regulated microtubule associated protein

  10. XM_039105062.2 → XP_038960990.1  targeting protein for Xklp2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ARV3, A6KHR8, D3ZA78
    Conserved Domains (3) summary
    pfam09041
    Location:1 → 68
    Aurora-A_bind; Aurora-A binding
    pfam06886
    Location:658 → 738
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam12214
    Location:365 → 487
    TPX2_importin; Cell cycle regulated microtubule associated protein

  11. XM_039105060.2 → XP_038960988.1  targeting protein for Xklp2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ARV3, A6KHR8, D3ZA78
    Related
    ENSRNOP00000010851.4, ENSRNOT00000010851.7
    Conserved Domains (3) summary
    pfam09041
    Location:1 → 68
    Aurora-A_bind; Aurora-A binding
    pfam06886
    Location:658 → 738
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam12214
    Location:365 → 487
    TPX2_importin; Cell cycle regulated microtubule associated protein
Nucleotide Protein Strain
Heading Accession and Version

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