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Large2 LARGE xylosyl- and glucuronyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311202, updated on 2-Nov-2024

Summary

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Official Symbol
Large2provided by RGD
Official Full Name
LARGE xylosyl- and glucuronyltransferase 2provided by RGD
Primary source
RGD:735214
See related
EnsemblRapid:ENSRNOG00000006353 AllianceGenome:RGD:735214
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gyltl1b
Summary
Predicted to enable dystroglycan binding activity; glucuronosyltransferase activity; and xylosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in Golgi apparatus. Orthologous to human LARGE2 (LARGE xylosyl- and glucuronyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 39.1), Lung (RPKM 17.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Large2 in Genome Data Viewer
Location:
3q24
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (98791543..98800251, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (78334627..78347167, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (81276020..81285457, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene PHD finger protein 21A Neighboring gene large ribosomal subunit protein eL34-like Neighboring gene small nucleolar RNA SNORA21 Neighboring gene uncharacterized LOC134486123 Neighboring gene peroxisomal biogenesis factor 16 Neighboring gene mitogen-activated protein kinase 8 interacting protein 1 Neighboring gene Frey regulator of sperm-oocyte fusion 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. LARGE2 generates the same xylose- and glucuronic acid-containing glycan structures as LARGE. Ashikov A, et al. Glycobiology, 2013 Mar. PMID 23135544
  2. Xylosyl- and glucuronyltransferase functions of LARGE in α-dystroglycan modification are conserved in LARGE2. Inamori K, et al. Glycobiology, 2013 Mar. PMID 23125099, Free PMC Article
  3. Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of α-dystroglycan in cells and tissues. Inamori K, et al. J Biol Chem, 2014 Oct 10. PMID 25138275, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC72631

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables dystroglycan binding ISO
Inferred from Sequence Orthology
more info
  
enables glucuronosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucuronosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucuronosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables xylosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables xylosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables xylosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein O-linked mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked mannosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein O-linked mannosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked mannosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
xylosyl- and glucuronyltransferase LARGE2
Names
glycosyltransferase-like 1B
glycosyltransferase-like protein LARGE2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199107.2 → NP_954538.1  xylosyl- and glucuronyltransferase LARGE2

    See identical proteins and their annotated locations for NP_954538.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q6P7A1
    UniProtKB/TrEMBL
    A6HNG2, A6HNG3
    Conserved Domains (2) summary
    cd06431
    Location:67 → 346
    GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
    pfam13896
    Location:401 → 635
    Glyco_transf_49; Glycosyl-transferase for dystroglycan

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    98791543..98800251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283669.1 → XP_063139739.1  xylosyl- and glucuronyltransferase LARGE2 isoform X2

    UniProtKB/TrEMBL
    A0A8L2QLT7

  2. XM_006234562.5 → XP_006234624.1  xylosyl- and glucuronyltransferase LARGE2 isoform X1

    See identical proteins and their annotated locations for XP_006234624.1

    UniProtKB/TrEMBL
    A6HNG3
    Conserved Domains (3) summary
    cd06431
    Location:92 → 371
    GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
    COG1442
    Location:93 → 340
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
    pfam13896
    Location:426 → 660
    Glyco_transf_49; Glycosyl-transferase for dystroglycan

  3. XM_017591719.3 → XP_017447208.1  xylosyl- and glucuronyltransferase LARGE2 isoform X6

    UniProtKB/TrEMBL
    A0A8I6ACM6, A6HNG3
    Related
    ENSRNOP00000089432.1, ENSRNOT00000098647.2

  4. XM_063283670.1 → XP_063139740.1  xylosyl- and glucuronyltransferase LARGE2 isoform X4

  5. XM_063283671.1 → XP_063139741.1  xylosyl- and glucuronyltransferase LARGE2 isoform X7

  6. XM_017591718.3 → XP_017447207.1  xylosyl- and glucuronyltransferase LARGE2 isoform X5

    UniProtKB/TrEMBL
    A6HNG3

  7. XM_006234566.5 → XP_006234628.1  xylosyl- and glucuronyltransferase LARGE2 isoform X3

    UniProtKB/TrEMBL
    A6HNG3
    Conserved Domains (3) summary
    cd06431
    Location:68 → 347
    GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
    COG1442
    Location:69 → 316
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
    pfam13896
    Location:402 → 606
    Glyco_transf_49; Glycosyl-transferase for dystroglycan

  8. XM_006234564.5 → XP_006234626.1  xylosyl- and glucuronyltransferase LARGE2 isoform X2

    UniProtKB/TrEMBL
    A0A8L2QLT7, A6HNG3
    Related
    ENSRNOP00000041797.3, ENSRNOT00000051258.5
    Conserved Domains (3) summary
    cd06431
    Location:68 → 347
    GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
    COG1442
    Location:69 → 316
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
    pfam13896
    Location:402 → 636
    Glyco_transf_49; Glycosyl-transferase for dystroglycan

  9. XM_008762024.4 → XP_008760246.1  xylosyl- and glucuronyltransferase LARGE2 isoform X1

    See identical proteins and their annotated locations for XP_008760246.1

    UniProtKB/TrEMBL
    A6HNG3
    Related
    ENSRNOP00000100953.1, ENSRNOT00000147683.1
    Conserved Domains (3) summary
    cd06431
    Location:92 → 371
    GT8_LARGE_C; LARGE catalytic domain has closest homology to GT8 glycosyltransferase involved in lipooligosaccharide synthesis
    COG1442
    Location:93 → 340
    RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]
    pfam13896
    Location:426 → 660
    Glyco_transf_49; Glycosyl-transferase for dystroglycan
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P7A1.1 GenPept UniProtKB/Swiss-Prot:Q6P7A1

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