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Klhl23 kelch-like family member 23 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311114, updated on 2-Nov-2024

Summary

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Official Symbol
Klhl23provided by RGD
Official Full Name
kelch-like family member 23provided by RGD
Primary source
RGD:1307166
See related
EnsemblRapid:ENSRNOG00000007981 AllianceGenome:RGD:1307166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307166
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL23 (kelch like family member 23). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 146.5), Muscle (RPKM 91.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Klhl23 in Genome Data Viewer
Location:
3q21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (74988778..75002347)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (54580788..54594530)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (56056957..56070614)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 210 Neighboring gene phosphatase, orphan 2 Neighboring gene small nucleolar RNA U13 Neighboring gene small RNA binding exonuclease protection factor La Neighboring gene methyltransferase 5, N6-adenosine

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kelch-like protein 23
Names
kelch-like 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134504.2 → NP_001127976.1  kelch-like protein 23 isoform b

    See identical proteins and their annotated locations for NP_001127976.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HM17, D3ZLV9
    Related
    ENSRNOP00000010508.5, ENSRNOT00000010508.7
    Conserved Domains (6) summary
    smart00612
    Location:322 → 369
    Kelch; Kelch domain
    PHA03098
    Location:45 → 545
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:359 → 402
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:33 → 131
    BTB; BTB/POZ domain
    pfam01344
    Location:358 → 402
    Kelch_1; Kelch motif
    pfam07707
    Location:139 → 239
    BACK; BTB And C-terminal Kelch

  2. NM_001431692.1 → NP_001418621.1  kelch-like protein 23 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  3. NM_001431693.1 → NP_001418622.1  kelch-like protein 23 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  4. NM_001431694.1 → NP_001418623.1  kelch-like protein 23 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  5. NM_001431695.1 → NP_001418624.1  kelch-like protein 23 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    74988778..75002347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234314.4 → XP_006234376.1  kelch-like protein 23 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JW57
    Related
    ENSRNOP00000109898.1, ENSRNOT00000128326.1
    Conserved Domains (6) summary
    smart00612
    Location:509 → 557
    Kelch; Kelch domain
    PHA03098
    Location:45 → 545
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:359 → 402
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:33 → 131
    BTB; BTB/POZ domain
    pfam01344
    Location:358 → 402
    Kelch_1; Kelch motif
    pfam07707
    Location:139 → 239
    BACK; BTB And C-terminal Kelch

  2. XM_006234316.5 → XP_006234378.1  kelch-like protein 23 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JW57
    Conserved Domains (6) summary
    smart00612
    Location:509 → 557
    Kelch; Kelch domain
    PHA03098
    Location:45 → 545
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:359 → 402
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:33 → 131
    BTB; BTB/POZ domain
    pfam01344
    Location:358 → 402
    Kelch_1; Kelch motif
    pfam07707
    Location:139 → 239
    BACK; BTB And C-terminal Kelch

  3. XM_006234313.5 → XP_006234375.1  kelch-like protein 23 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JW57
    Related
    ENSRNOP00000069751.2, ENSRNOT00000088351.3
    Conserved Domains (6) summary
    smart00612
    Location:517 → 565
    Kelch; Kelch domain
    PHA03098
    Location:53 → 553
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:367 → 410
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:41 → 139
    BTB; BTB/POZ domain
    pfam01344
    Location:366 → 410
    Kelch_1; Kelch motif
    pfam07707
    Location:147 → 247
    BACK; BTB And C-terminal Kelch
Nucleotide Protein Strain
Heading Accession and Version

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