U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tanc1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311055, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Tanc1provided by RGD
Official Full Name
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1provided by RGD
Primary source
RGD:1302949
See related
EnsemblRapid:ENSRNOG00000025394 AllianceGenome:RGD:1302949
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tanc
Summary
Involved in regulation of postsynapse organization. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human TANC1 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 110.7), Lung (RPKM 56.1) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tanc1 in Genome Data Viewer
Location:
3q21
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (64508037..64741826)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (44099387..44335478)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (45683773..45917687)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene death associated protein-like 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134486097 Neighboring gene uncharacterized LOC108350580 Neighboring gene WD repeat, sterile alpha motif and U-box domain containing 1 Neighboring gene bromodomain adjacent to zinc finger domain, 2B

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma. Avirneni-Vadlamudi U, et al. J Clin Invest, 2012 Jan. PMID 22182840, Free PMC Article
  2. Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins. Han S, et al. J Neurosci, 2010 Nov 10. PMID 21068316, Free PMC Article
  3. MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1. Nonaka H, et al. Biochem Biophys Res Commun, 2008 Dec 12. PMID 18930710
  4. Seizures are regulated by ubiquitin-specific peptidase 9 X-linked (USP9X), a de-ubiquitinase. Paemka L, et al. PLoS Genet, 2015 Mar. PMID 25763846, Free PMC Article
  5. A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins. Suzuki T, et al. Eur J Neurosci, 2005 Jan. PMID 15673434

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TANC protein may work as a postsynaptic scaffold component by forming a multiprotein complex with various postsynaptic density proteins.
    Title: A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA1728

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in dendritic spine maintenance IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dendritic spine maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in myoblast fusion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within myoblast fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in visual learning IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within visual learning ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon terminus IEA
Inferred from Electronic Annotation
more info
  
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density, intracellular component IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density, intracellular component IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein TANC1
Names
TPR domain, ankyrin-repeat and coiled-coil domain-containing protein 1
TPR domain, ankyrin-repeat and coiled-coil-containing

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002854.2 → NP_001002854.2  protein TANC1 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  2. NM_001431669.1 → NP_001418598.1  protein TANC1 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  3. NM_001431670.1 → NP_001418599.1  protein TANC1 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    64508037..64741826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283615.1 → XP_063139685.1  protein TANC1 isoform X1

    UniProtKB/TrEMBL
    A6JF67, G3V917

  2. XM_006234204.4 → XP_006234266.1  protein TANC1 isoform X1

    See identical proteins and their annotated locations for XP_006234266.1

    UniProtKB/Swiss-Prot
    Q6F6B3
    UniProtKB/TrEMBL
    A6JF67, G3V917
    Related
    ENSRNOP00000033136.6, ENSRNOT00000038983.7
    Conserved Domains (5) summary
    PHA03095
    Location:903 → 1215
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1282 → 1413
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1289 → 1314
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1142 → 1172
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1113 → 1205
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_017591681.3 → XP_017447170.1  protein TANC1 isoform X2

    Related
    ENSRNOP00000088260.1, ENSRNOT00000115662.2

  4. XM_039104830.2 → XP_038960758.1  protein TANC1 isoform X1

    UniProtKB/Swiss-Prot
    Q6F6B3
    UniProtKB/TrEMBL
    A6JF67, G3V917
    Conserved Domains (5) summary
    PHA03095
    Location:903 → 1215
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1282 → 1413
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1289 → 1314
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1142 → 1172
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1113 → 1205
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_063283616.1 → XP_063139686.1  protein TANC1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6F6B3.1 GenPept UniProtKB/Swiss-Prot:Q6F6B3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools