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Cyp2u1 cytochrome P450, family 2, subfamily u, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310848, updated on 2-Nov-2024

Summary

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Official Symbol
Cyp2u1provided by RGD
Official Full Name
cytochrome P450, family 2, subfamily u, polypeptide 1provided by RGD
Primary source
RGD:1309433
See related
EnsemblRapid:ENSRNOG00000011053 AllianceGenome:RGD:1309433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable arachidonate omega-hydroxylase activity; heme binding activity; and steroid hydroxylase activity. Predicted to be involved in omega-hydroxylase P450 pathway and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane and mitochondrial inner membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 56. Orthologous to human CYP2U1 (cytochrome P450 family 2 subfamily U member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 76.8), Lung (RPKM 64.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cyp2u1 in Genome Data Viewer
Location:
2q43
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (222523516..222541055, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (219849403..219866959, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (236414131..236431650, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene lymphoid enhancer binding factor 1 Neighboring gene uncharacterized LOC120100943 Neighboring gene hydroxyacyl-CoA dehydrogenase Neighboring gene uncharacterized LOC134485686 Neighboring gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 1, pseudogene 1 Neighboring gene uncharacterized LOC108350108 Neighboring gene sphingomyelin synthase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Oxidation of endogenous N-arachidonoylserotonin by human cytochrome P450 2U1. Siller M, et al. J Biol Chem, 2014 Apr 11. PMID 24563460, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables arachidonate omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid omega-hydroxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in omega-hydroxylase P450 pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 2U1
Names
long-chain fatty acid omega-monooxygenase
NP_001380742.1
XP_038958377.1
XP_063138025.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393813.2 → NP_001380742.1  cytochrome P450 2U1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q4V8D1
    UniProtKB/TrEMBL
    A0A8L2UPN4
    Related
    ENSRNOP00000099865.1, ENSRNOT00000147579.1
    Conserved Domains (1) summary
    cd20666
    Location:100 → 525
    CYP2U1; cytochrome P450 family 2, subfamily U, polypeptide 1

RNA

  1. NR_172016.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    222523516..222541055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102449.2 → XP_038958377.1  cytochrome P450 2U1 isoform X2

    Conserved Domains (2) summary
    cl12078
    Location:39 → 139
    p450; Cytochrome P450
    cl41757
    Location:149 → 313
    cytochrome_P450; cytochrome P450 (CYP) superfamily

  2. XM_063281955.1 → XP_063138025.1  cytochrome P450 2U1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V8D1.1 GenPept UniProtKB/Swiss-Prot:Q4V8D1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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