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Mybphl myosin binding protein H-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 310782, updated on 2-Nov-2024

Summary

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Official Symbol
Mybphlprovided by RGD
Official Full Name
myosin binding protein H-likeprovided by RGD
Primary source
RGD:1310511
See related
EnsemblRapid:ENSRNOG00000037082 AllianceGenome:RGD:1310511
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310511
Summary
Predicted to act upstream of or within in utero embryonic development. Predicted to be located in myofilament. Orthologous to human MYBPHL (myosin binding protein H like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 133.9), Lung (RPKM 27.7) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Mybphl in Genome Data Viewer
Location:
2q34
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (198692857..198706953)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (196005297..196018826)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (211158902..211173036)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit alpha 5 Neighboring gene sortilin 1 Neighboring gene uncharacterized LOC134485672 Neighboring gene proline and serine rich coiled-coil 1 Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Experimental Modeling Supports a Role for MyBP-HL as a Novel Myofilament Component in Arrhythmia and Dilated Cardiomyopathy. Barefield DY, et al. Circulation, 2017 Oct 17. PMID 28778945, Free PMC Article
  2. Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wilson R, et al. Wellcome Open Res, 2016. PMID 27996060, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in myofilament ISO
Inferred from Sequence Orthology
more info
  
located_in myofilament ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in sarcomere IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myosin-binding protein H-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014042.1 → NP_001014064.1  myosin-binding protein H-like

    See identical proteins and their annotated locations for NP_001014064.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087113
    UniProtKB/Swiss-Prot
    Q5PQM4
    UniProtKB/TrEMBL
    A6HUZ7
    Related
    ENSRNOP00000027099.4, ENSRNOT00000027099.7
    Conserved Domains (5) summary
    cd00096
    Location:281 → 345
    Ig; Immunoglobulin domain
    smart00410
    Location:62 → 143
    IG_like; Immunoglobulin like
    cd00063
    Location:147 → 235
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:262 → 351
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:71 → 143
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    198692857..198706953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233150.5 → XP_006233212.1  myosin-binding protein H-like isoform X1

    See identical proteins and their annotated locations for XP_006233212.1

    UniProtKB/Swiss-Prot
    Q5PQM4
    UniProtKB/TrEMBL
    A6HUZ7
    Conserved Domains (5) summary
    cd00096
    Location:281 → 345
    Ig; Immunoglobulin domain
    smart00410
    Location:62 → 143
    IG_like; Immunoglobulin like
    cd00063
    Location:147 → 235
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:262 → 351
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:71 → 143
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PQM4.1 GenPept UniProtKB/Swiss-Prot:Q5PQM4

Gene LinkOut

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