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Mov10 Mov10 RNA helicase [ Rattus norvegicus (Norway rat) ]

Gene ID: 310756, updated on 9-Dec-2024

Summary

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Official Symbol
Mov10provided by RGD
Official Full Name
Mov10 RNA helicaseprovided by RGD
Primary source
RGD:1598327
See related
EnsemblRapid:ENSRNOG00000012946 AllianceGenome:RGD:1598327
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Capza1
Summary
Predicted to enable 5'-3' RNA helicase activity and RNA binding activity. Predicted to be involved in defense response to virus; mRNA destabilization; and regulation of neuron projection arborization. Predicted to be located in P-body and nucleus. Predicted to be active in P granule and cytosol. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human MOV10 (Mov10 RNA helicase). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Spleen (RPKM 52.9), Kidney (RPKM 45.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mov10 in Genome Data Viewer
Location:
2q34
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (194982014..195003513, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (192292041..192315142, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (207277088..207301245, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 3 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1J Neighboring gene ras homolog family member C Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene suppression of tumorigenicity 7-like Neighboring gene Wnt family member 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. NMDAR mediated translation at the synapse is regulated by MOV10 and FMRP. Kute PM, et al. Mol Brain, 2019 Jul 10. PMID 31291981, Free PMC Article
  2. Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain. Skariah G, et al. BMC Biol, 2017 Jun 29. PMID 28662698, Free PMC Article
  3. MOV10 RNA helicase is a potent inhibitor of retrotransposition in cells. Goodier JL, et al. PLoS Genet, 2012. PMID 23093941, Free PMC Article
  4. Genetic variations in MOV10 and CACNB2 are associated with hypertension in a Chinese Han population. Hong GL, et al. Genet Mol Res, 2013 Dec 4. PMID 24338417
  5. Identification of novel argonaute-associated proteins. Meister G, et al. Curr Biol, 2005 Dec 6. PMID 16289642

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FMRP and MOV10 have an important regulatory role in NMDAR mediated translation at the synapse.
    Title: NMDAR mediated translation at the synapse is regulated by MOV10 and FMRP.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 5'-3' RNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA-mediated gene silencing by mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA-mediated post-transcriptional gene silencing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron projection arborization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transposable element silencing ISO
Inferred from Sequence Orthology
more info
  
involved_in transposable element silencing by mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
helicase MOV-10
Names
Moloney leukemia virus 10
Mov10 RISC complex RNA helicase
Mov10, Moloney leukemia virus 10
capping protein (actin filament) muscle Z-line, alpha 1
putative helicase MOV-10
NP_001101181.1
NP_001380739.1
XP_017446407.1
XP_063137981.1
XP_063137982.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107711.2 → NP_001101181.1  helicase MOV-10

    See identical proteins and their annotated locations for NP_001101181.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6K3P8, D3ZUC2
    Conserved Domains (2) summary
    cd18808
    Location:735 → 940
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18038
    Location:499 → 734
    DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

  2. NM_001393810.1 → NP_001380739.1  helicase MOV-10

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6K3P8, D3ZUC2
    Related
    ENSRNOP00000018061.6, ENSRNOT00000018061.8
    Conserved Domains (2) summary
    cd18808
    Location:735 → 940
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18038
    Location:499 → 734
    DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    194982014..195003513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590918.3 → XP_017446407.1  helicase MOV-10 isoform X1

    UniProtKB/TrEMBL
    A6K3P8, D3ZUC2
    Conserved Domains (2) summary
    cd18808
    Location:735 → 940
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18038
    Location:499 → 734
    DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

  2. XM_063281911.1 → XP_063137981.1  helicase MOV-10 isoform X2

    UniProtKB/TrEMBL
    D3ZUC2

  3. XM_063281912.1 → XP_063137982.1  helicase MOV-10 isoform X3

RNA

  1. XR_010063612.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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