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Plekho1 pleckstrin homology domain containing O1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310674, updated on 17-Aug-2024

Summary

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Official Symbol
Plekho1provided by RGD
Official Full Name
pleckstrin homology domain containing O1provided by RGD
Primary source
RGD:1311487
See related
EnsemblRapid:ENSRNOG00000021170 AllianceGenome:RGD:1311487
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ckip1; RGD1311487
Summary
Predicted to be involved in regulation of myoblast fusion. Predicted to act upstream of or within several processes, including lamellipodium morphogenesis; myoblast fusion; and myoblast migration. Predicted to be located in cytoplasm; membrane; and nucleus. Predicted to be active in muscle cell projection membrane and ruffle membrane. Orthologous to human PLEKHO1 (pleckstrin homology domain containing O1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 253.5), Spleen (RPKM 168.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q34
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186233435..186242114, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183544487..183552928, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198112104..198120202, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene acidic nuclear phosphoprotein 32 family member E Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 like 1 Neighboring gene vacuolar protein sorting 45 homolog Neighboring gene 60S ribosomal protein L15 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Overexpression of CKIP-1 alleviates hypoxia-induced cardiomyocyte injury by up-regulating Nrf2 antioxidant signaling via Keap1 inhibition. Ren J, et al. Biochimie, 2019 Aug. PMID 31201843
  2. Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging. Liu J, et al. Aging Cell, 2017 Apr. PMID 28083909, Free PMC Article
  3. CKIP-1 regulates mammalian and zebrafish myoblast fusion. Baas D, et al. J Cell Sci, 2012 Aug 15. PMID 22553210
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CKIP-1 alleviates hypoxia-induced cardiomyocyte injury through the up-regulation of Nrf2 antioxidant signaling via the down-regulation of Keap1, suggesting a potential role for CKIP-1 in myocardial infarction.
    Title: Overexpression of CKIP-1 alleviates hypoxia-induced cardiomyocyte injury by up-regulating Nrf2 antioxidant signaling via Keap1 inhibition.
  2. the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging.
    Title: Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC109581

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in lamellipodium morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lamellipodium morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in myoblast fusion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within myoblast fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in myoblast migration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within myoblast migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of myoblast fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in muscle cell projection membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in muscle cell projection membrane IEA
Inferred from Electronic Annotation
more info
  
located_in muscle cell projection membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family O member 1
Names
CK2 interacting protein 1
PH domain-containing family O member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025119.1 → NP_001020290.1  pleckstrin homology domain-containing family O member 1

    See identical proteins and their annotated locations for NP_001020290.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091420
    UniProtKB/Swiss-Prot
    Q5BJM5
    UniProtKB/TrEMBL
    A6K347
    Related
    ENSRNOP00000108174.1, ENSRNOT00000122271.1
    Conserved Domains (3) summary
    cd13317
    Location:21 → 126
    PH_PLEKHO1_PLEKHO2; Pleckstrin homology domain-containing family O Pleckstrin homology domain
    pfam00169
    Location:25 → 130
    PH; PH domain
    pfam15764
    Location:236 → 381
    DUF4693; Domain of unknown function (DUF4693)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    186233435..186242114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102374.2 → XP_038958302.1  pleckstrin homology domain-containing family O member 1 isoform X3

    Conserved Domains (1) summary
    cl17171
    Location:15 → 77
    PH-like; Pleckstrin homology-like domain

  2. XM_039102375.2 → XP_038958303.1  pleckstrin homology domain-containing family O member 1 isoform X4

    Conserved Domains (1) summary
    cl17171
    Location:13 → 71
    PH-like; Pleckstrin homology-like domain

  3. XM_039102373.2 → XP_038958301.1  pleckstrin homology domain-containing family O member 1 isoform X2

    UniProtKB/TrEMBL
    A6K346
    Conserved Domains (1) summary
    cl17171
    Location:21 → 79
    PH-like; Pleckstrin homology-like domain

  4. XM_063281879.1 → XP_063137949.1  pleckstrin homology domain-containing family O member 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2KBB3
    Related
    ENSRNOP00000075725.2, ENSRNOT00000079621.3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BJM5.1 GenPept UniProtKB/Swiss-Prot:Q5BJM5

Gene LinkOut

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