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Prune1 prune exopolyphosphatase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310664, updated on 2-Nov-2024

Summary

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Official Symbol
Prune1provided by RGD
Official Full Name
prune exopolyphosphatase 1provided by RGD
Primary source
RGD:1359521
See related
EnsemblRapid:ENSRNOG00000021120 AllianceGenome:RGD:1359521
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Prune
Summary
Predicted to enable exopolyphosphatase activity; phosphatase activity; and tubulin binding activity. Predicted to be involved in regulation of microtubule polymerization and regulation of neurogenesis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human PRUNE1 (prune exopolyphosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 86.2), Muscle (RPKM 81.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prune1 in Genome Data Viewer
Location:
2q34
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185519569..185548402, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182830575..182859972, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196427714..196457105, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 1 open reading frame 56 Neighboring gene BCL2 interacting protein like Neighboring gene MINDY lysine 48 deubiquitinase 1 Neighboring gene annexin A9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PRUNE is crucial for normal brain development and mutated in microcephaly with neurodevelopmental impairment. Zollo M, et al. Brain, 2017 Apr 1. PMID 28334956, Free PMC Article
  2. Evidence for interaction between human PRUNE and nm23-H1 NDPKinase. Reymond A, et al. Oncogene, 1999 Dec 2. PMID 10602478
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC93997

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables exopolyphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inorganic diphosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables pyrophosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
exopolyphosphatase PRUNE1
Names
protein prune homolog
prune homolog
NP_001007698.1
XP_006232947.1
XP_017446388.1
XP_063137943.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007697.1 → NP_001007698.1  exopolyphosphatase PRUNE1

    See identical proteins and their annotated locations for NP_001007698.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079054
    UniProtKB/Swiss-Prot
    Q6AYG3
    UniProtKB/TrEMBL
    A0A8I6AAC6
    Related
    ENSRNOP00000028677.4, ENSRNOT00000028677.7
    Conserved Domains (2) summary
    PRK05427
    Location:20 → 361
    PRK05427; putative manganese-dependent inorganic pyrophosphatase; Provisional
    pfam02833
    Location:218 → 357
    DHHA2; DHHA2 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    185519569..185548402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232885.5 → XP_006232947.1  exopolyphosphatase PRUNE1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AAC6
    Conserved Domains (2) summary
    COG1227
    Location:21 → 253
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:218 → 304
    DHHA2; DHHA2 domain

  2. XM_017590899.3 → XP_017446388.1  exopolyphosphatase PRUNE1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AAC6
    Conserved Domains (2) summary
    COG1227
    Location:66 → 255
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:187 → 327
    DHHA2; DHHA2 domain

  3. XM_063281873.1 → XP_063137943.1  exopolyphosphatase PRUNE1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYG3.1 GenPept UniProtKB/Swiss-Prot:Q6AYG3

Gene LinkOut

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