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Pmvk phosphomevalonate kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 310645, updated on 2-Nov-2024

Summary

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Official Symbol
Pmvkprovided by RGD
Official Full Name
phosphomevalonate kinaseprovided by RGD
Primary source
RGD:1310812
See related
EnsemblRapid:ENSRNOG00000020696 AllianceGenome:RGD:1310812
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables phosphomevalonate kinase activity. Involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in cytosol and peroxisome. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human PMVK (phosphomevalonate kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 216.0), Brain (RPKM 151.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pmvk in Genome Data Viewer
Location:
2q34
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (177174344..177184076)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174876586..174886365)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188784329..188793890)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene pygopus family PHD finger 2 Neighboring gene PBX homeobox interacting protein 1 Neighboring gene potassium calcium-activated channel subfamily N member 3 Neighboring gene uncharacterized LOC134485639 Neighboring gene adenosine deaminase, RNA-specific

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Loss-of-function Mutation in PMVK Causes Autosomal Dominant Disseminated Superficial Porokeratosis. Wang J, et al. Sci Rep, 2016 Apr 7. PMID 27052676, Free PMC Article
  2. Phosphomevalonate kinase: functional investigation of the recombinant human enzyme. Herdendorf TJ, et al. Biochemistry, 2006 Mar 14. PMID 16519518
  3. Phosphomevalonate kinase is a cytosolic protein in humans. Hogenboom S, et al. J Lipid Res, 2004 Apr. PMID 14729858
  4. Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting. Olivier LM, et al. J Lipid Res, 1999 Apr. PMID 10191291
  5. Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence. Chambliss KL, et al. J Biol Chem, 1996 Jul 19. PMID 8663599

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC105660

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphomevalonate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphomevalonate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphomevalonate kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to cholesterol ISO
Inferred from Sequence Orthology
more info
  
involved_in sterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
NOT located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphomevalonate kinase
NP_001008353.1
XP_017446383.1
XP_038958269.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008352.1 → NP_001008353.1  phosphomevalonate kinase

    See identical proteins and their annotated locations for NP_001008353.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086349
    UniProtKB/TrEMBL
    A0A8I5ZXC1, F7FJH6, Q5RK24
    Related
    ENSRNOP00000028095.3, ENSRNOT00000028095.7
    Conserved Domains (1) summary
    pfam04275
    Location:14 → 123
    P-mevalo_kinase; Phosphomevalonate kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    177174344..177184076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102341.2 → XP_038958269.1  phosphomevalonate kinase isoform X1

    Conserved Domains (1) summary
    cl04466
    Location:11 → 135
    P-mevalo_kinase; Phosphomevalonate kinase

  2. XM_017590894.3 → XP_017446383.1  phosphomevalonate kinase isoform X2

    UniProtKB/TrEMBL
    A6J6G7, A6J6G8
    Conserved Domains (1) summary
    cl04466
    Location:1 → 111
    P-mevalo_kinase; Phosphomevalonate kinase
Nucleotide Protein Strain
Heading Accession and Version

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