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Naa15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 310399, updated on 2-Nov-2024

Summary

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Official Symbol
Naa15provided by RGD
Official Full Name
N(alpha)-acetyltransferase 15, NatA auxiliary subunitprovided by RGD
Primary source
RGD:1310984
See related
EnsemblRapid:ENSRNOG00000012385 AllianceGenome:RGD:1310984
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Narg1
Summary
Predicted to enable N-acetyltransferase activity and acetyltransferase activator activity. Predicted to contribute to acetyltransferase activity and ribosome binding activity. Predicted to be involved in several processes, including N-terminal protein amino acid acetylation; positive regulation of DNA-templated transcription; and protein stabilization. Predicted to be located in cytosol and nuclear body. Predicted to be part of NatA complex and transcription regulator complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 50. Orthologous to human NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 210.2), Heart (RPKM 190.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Naa15 in Genome Data Viewer
Location:
2q26
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (137608883..137671618)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (135458018..135520756)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (140471437..140534259)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485908 Neighboring gene NADH:ubiquinone oxidoreductase subunit C1 Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene RAB33B, member RAS oncogene family Neighboring gene SET domain containing 7, histone lysine methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. NATH, a novel gene overexpressed in papillary thyroid carcinomas. Fluge Ø, et al. Oncogene, 2002 Aug 1. PMID 12140756
  2. Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. Arnesen T, et al. Biochem J, 2005 Mar 15. PMID 15496142, Free PMC Article
  3. Tubedown-1, a novel acetyltransferase associated with blood vessel development. Gendron RL, et al. Dev Dyn, 2000 Jun. PMID 10842358
  4. A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1). Arnesen T, et al. BMC Biochem, 2009 May 29. PMID 19480662, Free PMC Article
  5. An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development. Sugiura N, et al. J Biol Chem, 2003 Oct 10. PMID 12888564

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acetyltransferase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to ribosome binding ISO
Inferred from Sequence Orthology
more info
  
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in N-terminal protein amino acid acetylation IEA
Inferred from Electronic Annotation
more info
  
involved_in N-terminal protein amino acid acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of NatA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatA complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
N-alpha-acetyltransferase 15, NatA auxiliary subunit
Names
NMDA receptor regulated 1
NMDA receptor-regulated gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107674.1 → NP_001101144.1  N-alpha-acetyltransferase 15, NatA auxiliary subunit

    See identical proteins and their annotated locations for NP_001101144.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474003
    UniProtKB/TrEMBL
    A0A8I6A145, A6JV67, D3ZD89
    Related
    ENSRNOP00000017379.6, ENSRNOT00000017379.8
    Conserved Domains (3) summary
    sd00006
    Location:82 → 108
    TPR; TPR repeat [structural motif]
    pfam12569
    Location:187 → 698
    NARP1; NMDA receptor-regulated protein 1
    pfam13414
    Location:82 → 145
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    137608883..137671618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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