U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zfhx4 zinc finger homeobox 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310250, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Zfhx4provided by RGD
Official Full Name
zinc finger homeobox 4provided by RGD
Primary source
RGD:1563022
See related
EnsemblRapid:ENSRNOG00000008765 AllianceGenome:RGD:1563022
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563022
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZFHX4 (zinc finger homeobox 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 41.3), Lung (RPKM 34.1) and 6 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Zfhx4 in Genome Data Viewer
Location:
2q23
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (98131996..98321070, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (96224763..96408245, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (98423565..98610368, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene phosphoglycerate kinase 1, pseudogene 3 Neighboring gene peroxisomal biogenesis factor 2 Neighboring gene inosine monophosphate dehydrogenase 1, pseudogene 1 Neighboring gene uncharacterized LOC134485886 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. Chudnovsky Y, et al. Cell Rep, 2014 Jan 30. PMID 24440720, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger homeobox protein 4
Names
zinc finger homeodomain 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191702.1 → NP_001178631.1  zinc finger homeobox protein 4

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    D4A3U5
    Related
    ENSRNOP00000011641.5, ENSRNOT00000011641.7
    Conserved Domains (6) summary
    smart00389
    Location:2109 → 2164
    HOX; Homeodomain
    COG5576
    Location:2080 → 2219
    COG5576; Homeodomain-containing transcription factor [Transcription]
    sd00017
    Location:1522 → 1546
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1378 → 1398
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:2208 → 2261
    Homeobox; Homeobox domain
    pfam16278
    Location:1350 → 1394
    zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    98131996..98321070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281759.1 → XP_063137829.1  zinc finger homeobox protein 4 isoform X2

  2. XM_063281757.1 → XP_063137827.1  zinc finger homeobox protein 4 isoform X1

    UniProtKB/TrEMBL
    D4A3U5

  3. XM_006232162.5 → XP_006232224.1  zinc finger homeobox protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006232224.1

    UniProtKB/TrEMBL
    D4A3U5
    Conserved Domains (7) summary
    smart00389
    Location:2135 → 2190
    HOX; Homeodomain
    COG5189
    Location:1489 → 1616
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5576
    Location:2544 → 2666
    COG5576; Homeodomain-containing transcription factor [Transcription]
    sd00017
    Location:1548 → 1572
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1404 → 1424
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:2234 → 2288
    Homeobox; Homeobox domain
    NF033838
    Location:2398 → 2476
    PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form

  4. XM_063281758.1 → XP_063137828.1  zinc finger homeobox protein 4 isoform X2

  5. XM_006232164.5 → XP_006232226.1  zinc finger homeobox protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006232226.1

    UniProtKB/TrEMBL
    D4A3U5
    Related
    ENSRNOP00000100150.1, ENSRNOT00000148397.1
    Conserved Domains (7) summary
    smart00389
    Location:2135 → 2190
    HOX; Homeodomain
    COG5189
    Location:1489 → 1616
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5576
    Location:2544 → 2666
    COG5576; Homeodomain-containing transcription factor [Transcription]
    sd00017
    Location:1548 → 1572
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1404 → 1424
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:2234 → 2288
    Homeobox; Homeobox domain
    NF033838
    Location:2398 → 2476
    PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools