Car1 carbonic anhydrase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Car1provided by RGD
Official Full Name: carbonic anhydrase 1provided by RGD
Primary source: RGD:1309780
See related: EnsemblRapid:ENSRNOG00000010698 AllianceGenome:RGD:1309780
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ca1; CA-I
Summary: Predicted to enable arylesterase activity and carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in cytoplasm. Orthologous to human CA1 (carbonic anhydrase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1105.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q23

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (88550681..88593454)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (86829436..86872209)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (88185204..88227486)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myocardial carbonic anhydrase 1/2 activation is significantly elevated in diabetic ischemic cardiomyopathy.
Title: Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arylesterase activity	ISO Inferred from Sequence Orthology more info
enables carbonate dehydratase activity	ISO Inferred from Sequence Orthology more info
enables carbonate dehydratase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cyanamide hydratase activity	ISO Inferred from Sequence Orthology more info
enables cyanamide hydratase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydro-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydro-lyase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in one-carbon metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: carbonic anhydrase 1

Names: carbonic anhydrase I; cyanamide hydratase CA1

NP_001101130.1

EC 4.2.1.1

EC 4.2.1.69

XP_008759064.1

EC 4.2.1.1

EC 4.2.1.69

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107660.1 → NP_001101130.1 carbonic anhydrase 1

See identical proteins and their annotated locations for NP_001101130.1

Status: PROVISIONAL

Source sequence(s)

CH473961

UniProtKB/Swiss-Prot

B0BNN3

Related

ENSRNOP00000014267.4, ENSRNOT00000014267.7

Conserved Domains (1) summary

cl00012
Location:2 → 261

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

88550681..88593454

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008760842.2 → XP_008759064.1 carbonic anhydrase 1 isoform X1

See identical proteins and their annotated locations for XP_008759064.1

UniProtKB/Swiss-Prot

B0BNN3

Conserved Domains (1) summary

cl00012
Location:2 → 261

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...