Kat8 lysine acetyltransferase 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kat8provided by RGD
Official Full Name: lysine acetyltransferase 8provided by RGD
Primary source: RGD:1311512
See related: EnsemblRapid:ENSRNOG00000019485 AllianceGenome:RGD:1311512
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Myst1
Summary: Predicted to enable several functions, including N-acyltransferase activity; promoter-specific chromatin binding activity; and transcription coactivator activity. Predicted to contribute to histone H4K5 acetyltransferase activity and histone H4K8 acetyltransferase activity. Predicted to be involved in several processes, including hemopoiesis; positive regulation of skeletal muscle satellite cell differentiation; and regulation of gene expression. Predicted to act upstream of or within regulation of autophagy. Predicted to be located in chromosome; mitochondrion; and nuclear lumen. Predicted to be part of H4 histone acetyltransferase complex and MLL1 complex. Predicted to be active in chromosome and nucleus. Orthologous to human KAT8 (lysine acetyltransferase 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 359.0), Kidney (RPKM 212.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q37

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (191954827..191967107)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (182524355..182536638)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (199360645..199372925)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH136638 (e-PCR)
- UniSTS:218729

RH144608 (e-PCR)
- UniSTS:233853

AI179378 (e-PCR)
- UniSTS:250560

RH135325 (e-PCR)
- UniSTS:218602

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone H4 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K16 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H4K16 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
contributes_to histone H4K16 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K16 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K16 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H4K5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
contributes_to histone H4K5 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K5 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K5 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H4K5 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H4K8 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
contributes_to histone H4K8 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K8 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K8 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H4K8 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide-lysine-N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables peptide-lysine-N-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables promoter-specific chromatin binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein propionyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein propionyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein propionyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in dosage compensation by inactivation of X chromosome	IEA Inferred from Electronic Annotation more info
involved_in myeloid cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of type I interferon production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in oogenesis	IEA Inferred from Electronic Annotation more info
involved_in oogenesis	ISO Inferred from Sequence Orthology more info
involved_in oogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of skeletal muscle satellite cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of skeletal muscle satellite cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription initiation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription initiation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription initiation by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-embryonic hemopoiesis	IEA Inferred from Electronic Annotation more info
involved_in post-embryonic hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in post-embryonic hemopoiesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation-coupled chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of MLL1 complex	IEA Inferred from Electronic Annotation more info
part_of MLL1 complex	ISO Inferred from Sequence Orthology more info
part_of MLL1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of MSL complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MSL complex	IEA Inferred from Electronic Annotation more info
part_of MSL complex	ISO Inferred from Sequence Orthology more info
part_of MSL complex	ISS Inferred from Sequence or Structural Similarity more info
part_of NSL complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NSL complex	IEA Inferred from Electronic Annotation more info
part_of NSL complex	ISO Inferred from Sequence Orthology more info
part_of NSL complex	ISS Inferred from Sequence or Structural Similarity more info
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in chromosome	ISO Inferred from Sequence Orthology more info
is_active_in chromosome	ISS Inferred from Sequence or Structural Similarity more info
part_of histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of histone acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: histone acetyltransferase KAT8

Names: K (lysine) acetyltransferase 8; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST histone acetyltransferase 1; MYST protein 1; MYST-1; probable histone acetyltransferase MYST1; protein acetyltransferase KAT8; protein propionyltransferase KAT8

NP_001017378.1

EC 2.3.1.48

XP_038936795.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017378.1 → NP_001017378.1 histone acetyltransferase KAT8

See identical proteins and their annotated locations for NP_001017378.1

Status: PROVISIONAL

Source sequence(s)

BC083891

UniProtKB/Swiss-Prot

Q5XI06

UniProtKB/TrEMBL

A6I9W5, A6I9W6

Related

ENSRNOP00000026466.6, ENSRNOT00000026466.7

Conserved Domains (3) summary

PLN00104
Location:21 → 449

PLN00104; MYST -like histone acetyltransferase; Provisional

pfam11717
Location:55 → 111

Tudor-knot; RNA binding activity-knot of a chromodomain

cl17182
Location:160 → 427

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

191954827..191967107

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080867.2 → XP_038936795.1 histone acetyltransferase KAT8 isoform X1

Conserved Domains (1) summary

PLN00104
Location:6 → 291

PLN00104; MYST -like histone acetyltransferase; Provisional