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STOML2 stomatin like 2 [ Homo sapiens (human) ]

Gene ID: 30968, updated on 7-Apr-2024

Summary

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Official Symbol
STOML2provided by HGNC
Official Full Name
stomatin like 2provided by HGNC
Primary source
HGNC:HGNC:14559
See related
Ensembl:ENSG00000165283 MIM:608292; AllianceGenome:HGNC:14559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLP-2; HSPC108
Summary
Enables GTPase binding activity and cardiolipin binding activity. Involved in several processes, including inorganic cation transmembrane transport; positive regulation of cardiolipin metabolic process; and positive regulation of mitochondrial DNA replication. Located in membrane raft; mitochondrial inner membrane; and mitochondrial intermembrane space. Is extrinsic component of plasma membrane. Colocalizes with several cellular components, including COP9 signalosome; T cell receptor complex; and immunological synapse. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 27.8), heart (RPKM 26.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
9p13.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (35099776..35103195, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (35118954..35122373, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35099773..35103192, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:35078961-35079568 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:35079644-35079809 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:35080785-35081391 Neighboring gene FA complementation group G Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28320 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class O Neighboring gene PIGO antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28321 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28323 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28324 Neighboring gene GATA motif-containing MPRA enhancer 90 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19860 Neighboring gene atos homolog B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19861 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:35113841-35114670 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19862 Neighboring gene zinc finger protein 492 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. STOML2 restricts mitophagy and increases chemosensitivity in pancreatic cancer through stabilizing PARL-induced PINK1 degradation. Qin C, et al. Cell Death Dis, 2023 Mar 11. PMID 36906621, Free PMC Article
  2. Stomatin-Like Protein-2: A Potential Target to Treat Mitochondrial Cardiomyopathy. Hu Y, et al. Heart Lung Circ, 2021 Oct. PMID 34088631
  3. Stomatin-like protein 2 (SLP2) regulates the proliferation and invasion of trophoblast cells by modulating mitochondrial functions. Zhang X, et al. Placenta, 2020 Oct. PMID 32814233
  4. Clinical significance of SLP-2 in epithelial ovarian cancer and its regulatory effect on the Notch signaling pathway. Guo XY, et al. Eur Rev Med Pharmacol Sci, 2020 Feb. PMID 32141532
  5. Incidence and inheritance of hyperphosphorylated paratarg-7 in patients with Waldenstrom's macroglobulinaemia in Sweden. Brandefors L, et al. Acta Oncol, 2019 Jun. PMID 30888245

See all (174) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma.
    Title: Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma.
  2. Overexpressing lipid raft protein STOML2 modulates the tumor microenvironment via NF-kappaB signaling in colorectal cancer.
    Title: Overexpressing lipid raft protein STOML2 modulates the tumor microenvironment via NF-κB signaling in colorectal cancer.
  3. STOML2 restricts mitophagy and increases chemosensitivity in pancreatic cancer through stabilizing PARL-induced PINK1 degradation.
    Title: STOML2 restricts mitophagy and increases chemosensitivity in pancreatic cancer through stabilizing PARL-induced PINK1 degradation.
  4. CHCHD10 and SLP2 control the stability of the PHB complex: a key factor for motor neuron viability.
    Title: CHCHD10 and SLP2 control the stability of the PHB complex: a key factor for motor neuron viability.
  5. Characterization of the interactome of c-Src within the mitochondrial matrix by proximity-dependent biotin identification.
    Title: Characterization of the interactome of c-Src within the mitochondrial matrix by proximity-dependent biotin identification.
  6. Stomatinlike protein 2 induces metastasis by regulating the expression of a ratelimiting enzyme of the hexosamine biosynthetic pathway in pancreatic cancer.
    Title: Stomatin‑like protein 2 induces metastasis by regulating the expression of a rate‑limiting enzyme of the hexosamine biosynthetic pathway in pancreatic cancer.
  7. Stomatin-Like Protein-2: A Potential Target to Treat Mitochondrial Cardiomyopathy.
    Title: Stomatin-Like Protein-2: A Potential Target to Treat Mitochondrial Cardiomyopathy.
  8. Stomatin-like protein 2 (SLP2) regulates the proliferation and invasion of trophoblast cells by modulating mitochondrial functions.
    Title: Stomatin-like protein 2 (SLP2) regulates the proliferation and invasion of trophoblast cells by modulating mitochondrial functions.
  9. STOML2 potentiates metastasis of hepatocellular carcinoma by promoting PINK1-mediated mitophagy and regulates sensitivity to lenvatinib.
    Title: STOML2 potentiates metastasis of hepatocellular carcinoma by promoting PINK1-mediated mitophagy and regulates sensitivity to lenvatinib.
  10. Clinical significance of SLP-2 in epithelial ovarian cancer and its regulatory effect on the Notch signaling pathway.
    Title: Clinical significance of SLP-2 in epithelial ovarian cancer and its regulatory effect on the Notch signaling pathway.
Submit: New GeneRIF Correction See all GeneRIFs (47)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of stomatin (EPB72)-like 2 (SLP-2) in umbilical cord blood mononuclear cells and T-cell lines PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with stomatin (EPB72)-like 2 (STOML2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of stomatin (EPB72)-like 2 (STOML2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ98593

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables T cell receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cardiolipin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in CD4-positive, alpha-beta T cell activation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial protein processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interleukin-2 production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein complex oligomerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proton motive force-driven mitochondrial ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in stress-induced mitochondrial fusion ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
stomatin-like protein 2, mitochondrial
Names
EPB72-like 2
EPB72-like protein 2
paraprotein target 7
paratarg-7
stomatin (EPB72)-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287031.2 → NP_001273960.1  stomatin-like protein 2, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_001273960.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AA657517, AK303883, AW273545, HY367065
    Consensus CDS
    CCDS69588.1
    UniProtKB/Swiss-Prot
    Q9UJZ1
    Related
    ENSP00000395743.2, ENST00000452248.6
    Conserved Domains (2) summary
    COG0330
    Location:41 → 269
    HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]
    cd08829
    Location:74 → 147
    SPFH_paraslipin; Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  2. NM_001287032.1 → NP_001273961.1  stomatin-like protein 2, mitochondrial isoform c

    See identical proteins and their annotated locations for NP_001273961.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AA657517, AF190167, AW273545, BQ935988, BX400542, HY039403, HY367065
    UniProtKB/Swiss-Prot
    Q9UJZ1
    Conserved Domains (3) summary
    COG0330
    Location:2 → 263
    HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]
    cd08829
    Location:23 → 133
    SPFH_paraslipin; Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam16200
    Location:208 → 270
    Band_7_C; C-terminal region of band_7

  3. NM_001287033.2 → NP_001273962.1  stomatin-like protein 2, mitochondrial isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.
    Source sequence(s)
    AA657517, AW273545, BU528995, HY039403, HY367065
    Consensus CDS
    CCDS75830.1
    UniProtKB/TrEMBL
    A0A087WYB4
    Related
    ENSP00000481672.1, ENST00000619795.4
    Conserved Domains (2) summary
    COG0330
    Location:4 → 268
    HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]
    cd08829
    Location:28 → 138
    SPFH_paraslipin; Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  4. NM_013442.3 → NP_038470.1  stomatin-like protein 2, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_038470.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AA657517, AF190167, AW273545, HY367065
    Consensus CDS
    CCDS6577.1
    UniProtKB/Swiss-Prot
    B4E1K7, D3DRN3, O60376, Q53G29, Q96FY2, Q9P042, Q9UJZ1
    Related
    ENSP00000348886.5, ENST00000356493.10
    Conserved Domains (2) summary
    COG0330
    Location:41 → 314
    HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]
    cd08829
    Location:74 → 184
    SPFH_paraslipin; Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    35099776..35103195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    35118954..35122373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UJZ1.1 GenPept UniProtKB/Swiss-Prot:Q9UJZ1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
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Tools
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