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Slc7a9 solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 [ Mus musculus (house mouse) ]

Gene ID: 30962, updated on 2-Nov-2024

Summary

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Official Symbol
Slc7a9provided by MGI
Official Full Name
solute carrier family 7 (cationic amino acid transporter, y+ system), member 9provided by MGI
Primary source
MGI:MGI:1353656
See related
Ensembl:ENSMUSG00000030492 AllianceGenome:MGI:1353656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CSNU3
Summary
Predicted to enable amino acid transmembrane transporter activity; peptide antigen binding activity; and protein heterodimerization activity. Predicted to be involved in L-cystine transport and amino acid transmembrane transport. Located in brush border membrane. Is expressed in several structures, including metanephros and midgut. Used to study cystinuria. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC7A9 (solute carrier family 7 member 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in large intestine adult (RPKM 139.5), kidney adult (RPKM 97.6) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Slc7a9 in Genome Data Viewer
Location:
7 B2; 7 21.37 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (35148152..35165459)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (35448727..35466034)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E699 Neighboring gene centrosomal protein 89 Neighboring gene predicted gene, 42378 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene tudor domain containing 12 Neighboring gene stress-induced phosphoprotein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18633 Neighboring gene nudix hydrolase 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mouse model of type B cystinuria due to spontaneous mutation in FVB/NJcl mice. Sasaki H, et al. Urolithiasis, 2022 Dec. PMID 35988091
  2. Differential cystine and dibasic amino acid handling after loss of function of the amino acid transporter b0,+AT (Slc7a9) in mice. Di Giacopo A, et al. Am J Physiol Renal Physiol, 2013 Dec 15. PMID 24107421
  3. Slc7a9 knockout mouse is a good cystinuria model for antilithiasic pharmacological studies. Font-Llitjós M, et al. Am J Physiol Renal Physiol, 2007 Sep. PMID 17596531
  4. Slc7a9-deficient mice develop cystinuria non-I and cystine urolithiasis. Feliubadaló L, et al. Hum Mol Genet, 2003 Sep 1. PMID 12915471
  5. S-Methyl-L-Ergothioneine to L-Ergothioneine Ratio in Urine Is a Marker of Cystine Lithiasis in a Cystinuria Mouse Model. López de Heredia M, et al. Antioxidants (Basel), 2021 Sep 7. PMID 34573056, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tissue distribution, hormonal regulation, ontogeny, diurnal expression, and induction of mouse cystine transporters Slc3a1 and Slc7a9.
    Title: Tissue distribution, hormonal regulation, ontogeny, diurnal expression, and induction of mouse cystine transporters Slc3a1 and Slc7a9.
  2. A new protocol with d-penicillamine to validate our Slc7a9 knockout mouse model for the study of the therapeutic effect of drugs in the treatment of cystine lithiasis is reported.
    Title: Slc7a9 knockout mouse is a good cystinuria model for antilithiasic pharmacological studies.
  3. mouse amino acid transport system B0 is a neutral amino acid transporter related to Hartnup disorder
    Title: Molecular cloning of mouse amino acid transport system B0, a neutral amino acid transporter related to Hartnup disorder.
  4. a decreasing expression gradient of heterodimeric rBAT-b(0,+)AT along the proximal tubule is responsible for virtually all apical cystine reabsorption
    Title: rBAT-b(0,+)AT heterodimer is the main apical reabsorption system for cystine in the kidney.
  5. Slc7a9-deficient mice develop cystinuria non-I and cystine urolithiasis
    Title: Slc7a9-deficient mice develop cystinuria non-I and cystine urolithiasis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-cystine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-cystine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-cystine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables broad specificity neutral L-amino acid:basic L-amino acid antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables broad specificity neutral L-amino acid:basic L-amino acid antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables neutral L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neutral L-amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables neutral L-amino acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptide antigen binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-cystine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-cystine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-cystine transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in basic amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neutral amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in neutral amino acid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in brush border membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
B(0,+)-type amino acid transporter 1
Names
b(0,+)AT
b<o>, + amino acid transporter
b<o>, +AT
glycoprotein-associated amino acid transporter b0,+AT1
solute carrier family 7 member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199015.1 → NP_001185944.1  B(0,+)-type amino acid transporter 1

    See identical proteins and their annotated locations for NP_001185944.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AF192310, BE136295
    Consensus CDS
    CCDS21150.1
    UniProtKB/Swiss-Prot
    Q9QXA6
    UniProtKB/TrEMBL
    Q3UQE3
    Conserved Domains (1) summary
    TIGR00911
    Location:26 → 484
    2A0308; L-type amino acid transporter

  2. NM_001199016.1 → NP_001185945.1  B(0,+)-type amino acid transporter 1

    See identical proteins and their annotated locations for NP_001185945.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK142541, BE136295
    Consensus CDS
    CCDS21150.1
    UniProtKB/Swiss-Prot
    Q9QXA6
    UniProtKB/TrEMBL
    Q3UQE3
    Related
    ENSMUSP00000112726.2, ENSMUST00000118969.8
    Conserved Domains (1) summary
    TIGR00911
    Location:26 → 484
    2A0308; L-type amino acid transporter

  3. NM_021291.3 → NP_067266.1  B(0,+)-type amino acid transporter 1

    See identical proteins and their annotated locations for NP_067266.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AA104782, AC151535, AK142541, BE136295
    Consensus CDS
    CCDS21150.1
    UniProtKB/Swiss-Prot
    Q9QXA6
    UniProtKB/TrEMBL
    Q3UQE3
    Related
    ENSMUSP00000032703.10, ENSMUST00000032703.10
    Conserved Domains (1) summary
    TIGR00911
    Location:26 → 484
    2A0308; L-type amino acid transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    35148152..35165459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540045.3 → XP_006540108.1  B(0,+)-type amino acid transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_006540108.1

    UniProtKB/Swiss-Prot
    Q9QXA6
    UniProtKB/TrEMBL
    Q3UQE3
    Related
    ENSMUSP00000113181.2, ENSMUST00000118383.8
    Conserved Domains (1) summary
    TIGR00911
    Location:26 → 484
    2A0308; L-type amino acid transporter

  2. XM_011250591.2 → XP_011248893.1  B(0,+)-type amino acid transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_011248893.1

    UniProtKB/Swiss-Prot
    Q9QXA6
    UniProtKB/TrEMBL
    Q3UQE3
    Conserved Domains (1) summary
    TIGR00911
    Location:26 → 484
    2A0308; L-type amino acid transporter

  3. XM_006540044.2 → XP_006540107.1  B(0,+)-type amino acid transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_006540107.1

    UniProtKB/Swiss-Prot
    Q9QXA6
    UniProtKB/TrEMBL
    Q3UQE3
    Conserved Domains (1) summary
    TIGR00911
    Location:26 → 484
    2A0308; L-type amino acid transporter

  4. XM_006540047.2 → XP_006540110.1  B(0,+)-type amino acid transporter 1 isoform X3

    Conserved Domains (1) summary
    TIGR00911
    Location:26 → 326
    2A0308; L-type amino acid transporter

  5. XM_011250592.3 → XP_011248894.1  B(0,+)-type amino acid transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_011248894.1

    UniProtKB/Swiss-Prot
    Q9QXA6
    UniProtKB/TrEMBL
    Q3UQE3
    Conserved Domains (1) summary
    TIGR00911
    Location:26 → 484
    2A0308; L-type amino acid transporter

  6. XM_006540046.1 → XP_006540109.1  B(0,+)-type amino acid transporter 1 isoform X2

    Conserved Domains (1) summary
    TIGR00911
    Location:2 → 396
    2A0308; L-type amino acid transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QXA6.1 GenPept UniProtKB/Swiss-Prot:Q9QXA6

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