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Shoc2 SHOC2 leucine-rich repeat scaffold protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 309548, updated on 18-Sep-2024

Summary

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Official Symbol
Shoc2provided by RGD
Official Full Name
SHOC2 leucine-rich repeat scaffold proteinprovided by RGD
Primary source
RGD:1308146
See related
EnsemblRapid:ENSRNOG00000015339 AllianceGenome:RGD:1308146
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein phosphatase 1 binding activity. Predicted to be involved in positive regulation of Ras protein signal transduction and signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein phosphatase type 1 complex. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 1. Orthologous to human SHOC2 (SHOC2 leucine rich repeat scaffold protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 206.5), Kidney (RPKM 187.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Shoc2 in Genome Data Viewer
Location:
1q55
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (262964345..263052898)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (252958939..253048820)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (274700621..274751195)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 20 Neighboring gene uncharacterized LOC120100058 Neighboring gene programmed cell death 4 Neighboring gene small nucleolar RNA SNORA20 Neighboring gene uncharacterized LOC134484116 Neighboring gene BBSome interacting protein 1 Neighboring gene adrenoceptor alpha 2A Neighboring gene uncharacterized LOC120100059

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Study of the pathology and the underlying molecular mechanism of tissue injury around hematoma following intracerebral hemorrhage. Wang J, et al. Mol Med Rep, 2021 Oct. PMID 34368865, Free PMC Article
  2. Expanding the SHOC2 mutation associated phenotype of Noonan syndrome with loose anagen hair: structural brain anomalies and myelofibrosis. Gripp KW, et al. Am J Med Genet A, 2013 Oct. PMID 23918763, Free PMC Article
  3. Sur8/Shoc2 involves both inhibition of differentiation and maintenance of self-renewal of neural progenitor cells via modulation of extracellular signal-regulated kinase signaling. Moon BS, et al. Stem Cells, 2011 Feb. PMID 21732489
  4. Expanding the molecular spectrum of pathogenic SHOC2 variants underlying Mazzanti syndrome. Motta M, et al. Hum Mol Genet, 2022 Aug 23. PMID 35348676, Free PMC Article
  5. Shoc2/Sur8 protein regulates neurite outgrowth. Leon G, et al. PLoS One, 2014. PMID 25514808, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sur8 is an antidifferentiation factor that stimulates proliferation for maintenance of self-renewal in NPCs via modulation of the Ras-ERK pathway.
    Title: Sur8/Shoc2 involves both inhibition of differentiation and maintenance of self-renewal of neural progenitor cells via modulation of extracellular signal-regulated kinase signaling.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein phosphatase 1 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables volume-sensitive anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to growth hormone stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nerve growth factor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Ras protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein phosphatase type 1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of protein phosphatase type 1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
leucine-rich repeat protein SHOC-2
Names
protein soc-2 homolog
protein sur-8 homolog
soc-2 (suppressor of clear) homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013155.2 → NP_001013173.1  leucine-rich repeat protein SHOC-2

    See identical proteins and their annotated locations for NP_001013173.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q6AYI5
    UniProtKB/TrEMBL
    A6JHX2
    Conserved Domains (3) summary
    PLN03150
    Location:453 → 527
    PLN03150; hypothetical protein; Provisional
    PLN00113
    Location:115 → 483
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:240 → 262
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    262964345..263052898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080784.2 → XP_038936712.1  leucine-rich repeat protein SHOC-2 isoform X1

    UniProtKB/Swiss-Prot
    Q6AYI5
    UniProtKB/TrEMBL
    A6JHX2
    Conserved Domains (3) summary
    PLN03150
    Location:453 → 527
    PLN03150; hypothetical protein; Provisional
    PLN00113
    Location:115 → 483
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:240 → 262
    LRR_RI; leucine-rich repeat [structural motif]

  2. XM_039080785.2 → XP_038936713.1  leucine-rich repeat protein SHOC-2 isoform X1

    UniProtKB/Swiss-Prot
    Q6AYI5
    UniProtKB/TrEMBL
    A6JHX2
    Conserved Domains (3) summary
    PLN03150
    Location:453 → 527
    PLN03150; hypothetical protein; Provisional
    PLN00113
    Location:115 → 483
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:240 → 262
    LRR_RI; leucine-rich repeat [structural motif]

  3. XM_039080788.2 → XP_038936716.1  leucine-rich repeat protein SHOC-2 isoform X1

    UniProtKB/Swiss-Prot
    Q6AYI5
    UniProtKB/TrEMBL
    A6JHX2
    Related
    ENSRNOP00000020580.5, ENSRNOT00000020580.8
    Conserved Domains (3) summary
    PLN03150
    Location:453 → 527
    PLN03150; hypothetical protein; Provisional
    PLN00113
    Location:115 → 483
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:240 → 262
    LRR_RI; leucine-rich repeat [structural motif]

  4. XM_039080777.2 → XP_038936705.1  leucine-rich repeat protein SHOC-2 isoform X1

    UniProtKB/Swiss-Prot
    Q6AYI5
    UniProtKB/TrEMBL
    A6JHX2
    Conserved Domains (3) summary
    PLN03150
    Location:453 → 527
    PLN03150; hypothetical protein; Provisional
    PLN00113
    Location:115 → 483
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:240 → 262
    LRR_RI; leucine-rich repeat [structural motif]

  5. XM_039080789.2 → XP_038936717.1  leucine-rich repeat protein SHOC-2 isoform X1

    UniProtKB/Swiss-Prot
    Q6AYI5
    UniProtKB/TrEMBL
    A6JHX2
    Conserved Domains (3) summary
    PLN03150
    Location:453 → 527
    PLN03150; hypothetical protein; Provisional
    PLN00113
    Location:115 → 483
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:240 → 262
    LRR_RI; leucine-rich repeat [structural motif]

  6. XM_063265372.1 → XP_063121442.1  leucine-rich repeat protein SHOC-2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYI5.1 GenPept UniProtKB/Swiss-Prot:Q6AYI5

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