Slc16a12 solute carrier family 16, member 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc16a12provided by RGD
Official Full Name: solute carrier family 16, member 12provided by RGD
Primary source: RGD:1311468
See related: EnsemblRapid:ENSRNOG00000021916 AllianceGenome:RGD:1311468
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MCT 12; RGD1311468
Summary: Enables creatine transmembrane transporter activity. Involved in creatine transmembrane transport and creatinine metabolic process. Located in basolateral plasma membrane. Human ortholog(s) of this gene implicated in cataract 47. Orthologous to human SLC16A12 (solute carrier family 16 member 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 986.0), Liver (RPKM 342.5) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q53

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (241597165..241674821, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (232184004..232262170, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (252976071..253054500, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Solute carrier SLC16A12 is critical for creatine and guanidinoacetate handling in the kidney.
Title: Solute carrier SLC16A12 is critical for creatine and guanidinoacetate handling in the kidney.
Monocarboxylate transporter 12 as a guanidinoacetate efflux transporter in renal proximal tubular epithelial cells.
Title: Monocarboxylate transporter 12 as a guanidinoacetate efflux transporter in renal proximal tubular epithelial cells.
a model whereby the SLC16A12 (c.643C>T) mutation causes juvenile cataract by a defect in protein trafficking rather than by haploinsufficiency.
Title: Juvenile cataract-associated mutation of solute carrier SLC16A12 impairs trafficking of the protein to the plasma membrane.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables creatine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables creatine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables monocarboxylic acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables uniporter activity	ISO Inferred from Sequence Orthology more info
enables uniporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in creatine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in creatine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in creatine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in creatinine metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: monocarboxylate transporter 12

Names: solute carrier family 16 (monocarboxylic acid transporters), member 12; solute carrier family 16, member 12 (monocarboxylic acid transporter 12)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191637.1 → NP_001178566.1 monocarboxylate transporter 12

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

D4A734

Related

ENSRNOP00000104843.1, ENSRNOT00000167047.1

Conserved Domains (1) summary

cl26868
Location:12 → 451

2A0111; oxalate/formate antiporter family transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

241597165..241674821 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017589301.3 → XP_017444790.1 monocarboxylate transporter 12 isoform X1

UniProtKB/Swiss-Prot

D4A734

Conserved Domains (1) summary

cl26868
Location:12 → 451

2A0111; oxalate/formate antiporter family transporter
XM_017589300.3 → XP_017444789.1 monocarboxylate transporter 12 isoform X1

UniProtKB/Swiss-Prot

D4A734

Related

ENSRNOP00000038838.3, ENSRNOT00000030024.7

Conserved Domains (1) summary

cl26868
Location:12 → 451

2A0111; oxalate/formate antiporter family transporter