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Ppp1r3c protein phosphatase 1, regulatory subunit 3C [ Rattus norvegicus (Norway rat) ]

Gene ID: 309513, updated on 2-Nov-2024

Summary

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Symbol
Ppp1r3cprovided by RGD
Full Name
protein phosphatase 1, regulatory subunit 3Cprovided by RGD
Primary source
RGD:1309132
See related
AllianceGenome:RGD:1309132
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
R5; PTG
Summary
Enables [phosphorylase] phosphatase activity and enzyme binding activity. Contributes to phosphoprotein phosphatase activity. Involved in regulation of glycogen biosynthetic process and regulation of glycogen catabolic process. Located in glycogen granule. Orthologous to human PPP1R3C (protein phosphatase 1 regulatory subunit 3C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 1044.3), Liver (RPKM 443.3) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppp1r3c in Genome Data Viewer
Location:
1q53
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (243873524..243878527, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (234460958..234465961, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (255371830..255376833, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene HECT domain E3 ubiquitin protein ligase 2 Neighboring gene uncharacterized LOC134485231 Neighboring gene uncharacterized LOC120100025 Neighboring gene uncharacterized LOC102553702 Neighboring gene uncharacterized LOC134485232

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen. O'Doherty RM, et al. J Clin Invest, 2000 Feb. PMID 10683377, Free PMC Article
  2. The level of the glycogen targetting regulatory subunit R5 of protein phosphatase 1 is decreased in the livers of insulin-dependent diabetic rats and starved rats. Browne GJ, et al. Biochem J, 2001 Dec 1. PMID 11716774, Free PMC Article
  3. PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism. Printen JA, et al. Science, 1997 Mar 7. PMID 9045612
  4. PTG depletion removes Lafora bodies and rescues the fatal epilepsy of Lafora disease. Turnbull J, et al. PLoS Genet, 2011 Apr. PMID 21552327, Free PMC Article
  5. Abnormal metabolism of glycogen phosphate as a cause for Lafora disease. Tagliabracci VS, et al. J Biol Chem, 2008 Dec 5. PMID 18852261, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables [phosphorylase] phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables enzyme binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glycogen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycogen binding IEA
Inferred from Electronic Annotation
more info
  
enables glycogen binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycogen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within glycogen metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycogen metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of glycogen biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of glycogen catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in glycogen granule IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 3C
Names
PP1 subunit R5
protein phosphatase 1 regulatory subunit 3C-like
protein phosphatase 1 regulatory subunit 5
protein phosphatase 1, regulatory (inhibitor) subunit 3C
protein targeting to glycogen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012072.1 → NP_001012072.1  protein phosphatase 1 regulatory subunit 3C

    See identical proteins and their annotated locations for NP_001012072.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085894
    UniProtKB/Swiss-Prot
    Q5U2R5
    UniProtKB/TrEMBL
    A6I157, G3V8E0
    Conserved Domains (1) summary
    pfam03370
    Location:151 → 256
    CBM_21; Carbohydrate/starch-binding module (family 21)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    243873524..243878527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2R5.1 GenPept UniProtKB/Swiss-Prot:Q5U2R5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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