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Slc46a2 solute carrier family 46, member 2 [ Mus musculus (house mouse) ]

Gene ID: 30936, updated on 28-Oct-2024

Summary

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Official Symbol
Slc46a2provided by MGI
Official Full Name
solute carrier family 46, member 2provided by MGI
Primary source
MGI:MGI:1353616
See related
Ensembl:ENSMUSG00000028386 AllianceGenome:MGI:1353616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly110; Tscot; TSO-1C12; 5430429N04Rik
Summary
Predicted to enable cyclic-GMP-AMP transmembrane transporter activity. Acts upstream of or within several processes, including T cell homeostasis; negative regulation of T cell apoptotic process; and thymus development. Located in cell surface. Is expressed in several structures, including foregut gland; hemolymphoid system; and skin. Orthologous to human SLC46A2 (solute carrier family 46 member 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in thymus adult (RPKM 10.5), genital fat pad adult (RPKM 6.6) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Slc46a2 in Genome Data Viewer
Location:
4 B3; 4 32.81 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (59905899..59915056, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (59905899..59915056, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10382 Neighboring gene STARR-positive B cell enhancer ABC_E421 Neighboring gene STARR-seq mESC enhancer starr_10383 Neighboring gene INTS3 and NABP interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E7970 Neighboring gene STARR-positive B cell enhancer ABC_E3493 Neighboring gene STARR-positive B cell enhancer ABC_E6184 Neighboring gene STARR-positive B cell enhancer ABC_E9590 Neighboring gene STARR-positive B cell enhancer ABC_E10237 Neighboring gene sorting nexin family member 30 Neighboring gene STARR-seq mESC enhancer starr_10384 Neighboring gene sorting nexin 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:59891511-59891739 Neighboring gene STARR-positive B cell enhancer ABC_E4632 Neighboring gene STARR-seq mESC enhancer starr_10391 Neighboring gene STARR-seq mESC enhancer starr_10392 Neighboring gene major urinary protein 4 Neighboring gene STARR-seq mESC enhancer starr_10394 Neighboring gene major urinary protein 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression Analyses Revealed Thymic Stromal Co-Transporter/Slc46A2 Is in Stem Cell Populations and Is a Putative Tumor Suppressor. Kim KY, et al. Mol Cells, 2015 Jun. PMID 26013383, Free PMC Article
  2. Thymic epithelial requirement for γδ T cell development revealed in the cell ablation transgenic system with TSCOT promoter. Lee G, et al. Mol Cells, 2012 Nov. PMID 23178972, Free PMC Article
  3. Characterization of the mouse gene, human promoter and human cDNA of TSCOT reveals strong interspecies homology. Chen C, et al. Biochim Biophys Acta, 2000 Sep 7. PMID 10978518
  4. A putative 12 transmembrane domain cotransporter expressed in thymic cortical epithelial cells. Kim MG, et al. J Immunol, 2000 Mar 15. PMID 10706709
  5. TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation. Ahn S, et al. PLoS Biol, 2008 Aug 5. PMID 18684012, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression profiling of thymic stromal cotransporter (TSCOT), Slc46A2/Ly110, that was shown to be expressed in bipotent precursor and cortical thymic epithelial cells.
    Title: Expression Analyses Revealed Thymic Stromal Co-Transporter/Slc46A2 Is in Stem Cell Populations and Is a Putative Tumor Suppressor.
  2. Thymic epithelial requirement for gammadelta T cell development revealed in the cell ablation transgenic system with TSCOT promoter
    Title: Thymic epithelial requirement for γδ T cell development revealed in the cell ablation transgenic system with TSCOT promoter.
  3. the introduction of a neoantigen into TSCOT-expressing cells can efficiently establish complete tolerance and suggest a possible application for the deletion of antigen-specific T cells by antigen introduction into TSCOT+ cells.
    Title: TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclic-GMP-AMP transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables cyclic-GMP-AMP transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within T cell homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of T cell apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of T cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within thymus development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
solute carrier family 46 member 2
Names
putative thymic stromal co-transporter TSCOT
thymic stromal cotransporter homolog
thymic stromal cotransporter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021053.4 → NP_066395.3  solute carrier family 46 member 2

    See identical proteins and their annotated locations for NP_066395.3

    Status: VALIDATED

    Source sequence(s)
    AK040063, AL831738
    Consensus CDS
    CCDS18227.1
    UniProtKB/Swiss-Prot
    A2ANT4, Q8CA03, Q9D3J2, Q9JLQ3
    UniProtKB/TrEMBL
    A9R9W2
    Related
    ENSMUSP00000030081.2, ENSMUST00000030081.2
    Conserved Domains (2) summary
    cd06174
    Location:86 → 455
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:88 → 422
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    59905899..59915056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CA03.2 GenPept UniProtKB/Swiss-Prot:Q8CA03

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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