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Vps26a VPS26 retromer complex component A [ Mus musculus (house mouse) ]

Gene ID: 30930, updated on 2-Nov-2024

Summary

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Official Symbol
Vps26aprovided by MGI
Official Full Name
VPS26 retromer complex component Aprovided by MGI
Primary source
MGI:MGI:1353654
See related
Ensembl:ENSMUSG00000020078 AllianceGenome:MGI:1353654
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HB58; Vps26
Summary
Acts upstream of or within retrograde transport, endosome to Golgi. Located in early endosome. Part of retromer complex. Is expressed in several structures, including egg cylinder; embryo ectoderm; gut; inner cell mass; and ovary. Human ortholog(s) of this gene implicated in diabetic retinopathy and type 2 diabetes mellitus. Orthologous to human VPS26A (VPS26 retromer complex component A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 37.1), placenta adult (RPKM 23.8) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Vps26a in Genome Data Viewer
Location:
10 B4; 10 32.41 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62290622..62322584, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62454843..62486805, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene hexokinase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_26882 Neighboring gene predicted gene, 30322 Neighboring gene suppressor of var1, 3-like 1 (S. cerevisiae) Neighboring gene RIKEN cDNA 4930507D05 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61912425-61912612 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61912686-61912869 Neighboring gene STARR-seq mESC enhancer starr_26885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61949721-61949830 Neighboring gene STARR-seq mESC enhancer starr_26886 Neighboring gene STARR-positive B cell enhancer ABC_E6862 Neighboring gene STARR-positive B cell enhancer ABC_E6863 Neighboring gene STARR-positive B cell enhancer ABC_E6864 Neighboring gene serglycin Neighboring gene STARR-positive B cell enhancer ABC_E10614 Neighboring gene STARR-positive B cell enhancer ABC_E2327 Neighboring gene STARR-positive B cell enhancer ABC_E11441 Neighboring gene STARR-seq mESC enhancer starr_26888 Neighboring gene STARR-positive B cell enhancer ABC_E3889 Neighboring gene kinesin family binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine H beta 58 embryonic lethal transgene insertion. Lee JJ, et al. Development, 1992 May. PMID 1638986
  2. H beta 58, an insertional mutation affecting early postimplantation development of the mouse embryo. Radice G, et al. Development, 1991 Mar. PMID 1879343
  3. Alzheimer's vulnerable brain region relies on a distinct retromer core dedicated to endosomal recycling. Simoes S, et al. Cell Rep, 2021 Dec 28. PMID 34965419, Free PMC Article
  4. Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing. Fjorback AW, et al. J Neurosci, 2012 Jan 25. PMID 22279231, Free PMC Article
  5. High glucose-mediated VPS26a down-regulation dysregulates neuronal amyloid precursor protein processing and tau phosphorylation. Chae CW, et al. Br J Pharmacol, 2022 Aug. PMID 35297035

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High glucose-mediated VPS26a down-regulation dysregulates neuronal amyloid precursor protein processing and tau phosphorylation.
    Title: High glucose-mediated VPS26a down-regulation dysregulates neuronal amyloid precursor protein processing and tau phosphorylation.
  2. VPS26A binding increases the affinity of the SNX27 PDZ domain for PDZ- binding motifs by an order of magnitude, revealing cooperativity in cargo selection.
    Title: A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer.
  3. These results revealed that the retromer complex could be formed from different Vps26 isoforms in a tissue-specific manner.
    Title: Identification of novel retromer complexes in the mouse testis.
  4. Vps26 is implicated in regulating Vps35p membrane association, therefore Vps26 plays a role in cargo recognition of the cytoplasmic coat retromer complex.
    Title: Identification of a conserved motif required for Vps35p/Vps26p interaction and assembly of the retromer complex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytic recycling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retrograde transport, endosome to Golgi IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
part_of retromer complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of retromer complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of retromer complex ISO
Inferred from Sequence Orthology
more info
  
part_of retromer complex TAS
Traceable Author Statement
more info
 PubMed 
part_of retromer, cargo-selective complex IEA
Inferred from Electronic Annotation
more info
  
part_of retromer, cargo-selective complex ISO
Inferred from Sequence Orthology
more info
  
located_in tubular endosome ISO
Inferred from Sequence Orthology
more info
  
located_in tubular endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
vacuolar protein sorting-associated protein 26A
Names
H beta 58
h<beta>58 protein
mVPS26
vacuolar protein sorting 26 homolog A
vacuole protein sorting 26
vesicle protein sorting 26A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113355.1 → NP_001106826.1  vacuolar protein sorting-associated protein 26A isoform b

    See identical proteins and their annotated locations for NP_001106826.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. These differences cause translation initiation at a downstream ATG and an isoform (b) with a longer, distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK028096, AK147989, AK167592, CO801094
    Consensus CDS
    CCDS48579.1
    UniProtKB/Swiss-Prot
    P40336
    Related
    ENSMUSP00000090130.4, ENSMUST00000092473.5
    Conserved Domains (1) summary
    pfam03643
    Location:40 → 315
    Vps26; Vacuolar protein sorting-associated protein 26

  2. NM_001358543.1 → NP_001345472.1  vacuolar protein sorting-associated protein 26A isoform c

    Status: VALIDATED

    Source sequence(s)
    AK147989, AK167592, BB857335, CJ151367, CO801094
    Conserved Domains (1) summary
    pfam03643
    Location:2 → 172
    Vps26; Vacuolar protein sorting-associated protein 26

  3. NM_133672.3 → NP_598433.1  vacuolar protein sorting-associated protein 26A isoform a

    See identical proteins and their annotated locations for NP_598433.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AK147989, AK167592, BB857335, CO801094
    Consensus CDS
    CCDS35921.1
    UniProtKB/Swiss-Prot
    P40336, Q3TGY3, Q3THM5, Q3TW99, Q3UD54, Q8C1E9
    Related
    ENSMUSP00000101087.4, ENSMUST00000105447.11
    Conserved Domains (1) summary
    pfam03643
    Location:8 → 283
    Vps26; Vacuolar protein sorting-associated protein 26

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    62290622..62322584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40336.1 GenPept UniProtKB/Swiss-Prot:P40336

Gene LinkOut

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