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Frmd8 FERM domain containing 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309172, updated on 2-Nov-2024

Summary

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Official Symbol
Frmd8provided by RGD
Official Full Name
FERM domain containing 8provided by RGD
Primary source
RGD:1310323
See related
EnsemblRapid:ENSRNOG00000020881 AllianceGenome:RGD:1310323
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310323
Summary
Predicted to be involved in negative regulation of canonical Wnt signaling pathway and positive regulation of tumor necrosis factor production. Predicted to act upstream of or within protein localization to plasma membrane. Predicted to be located in centriolar satellite; cytosol; and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to several human genes including FRMD8 (FERM domain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 95.2), Adrenal (RPKM 92.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Frmd8 in Genome Data Viewer
Location:
1q43
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212572534..212593181, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203143216..203163868, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221213312..221233967, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene latent transforming growth factor beta binding protein 3 Neighboring gene SCY1 like pseudokinase 1 Neighboring gene uncharacterized LOC120097381 Neighboring gene nuclear paraspeckle assembly transcript 1 Neighboring gene U2 spliceosomal RNA Neighboring gene solute carrier family 25, member 45 Neighboring gene tigger transposable element derived 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex. Künzel U, et al. Elife, 2018 Jun 13. PMID 29897336, Free PMC Article
  2. iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE. Oikonomidi I, et al. Elife, 2018 Jun 13. PMID 29897333, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94709

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
FERM domain-containing protein 8
Names
FKSG44 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008348.1 → NP_001008349.1  FERM domain-containing protein 8

    See identical proteins and their annotated locations for NP_001008349.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085896
    UniProtKB/Swiss-Prot
    Q5U2R3
    UniProtKB/TrEMBL
    A0A1B0GWW6, A6HZA5
    Related
    ENSRNOP00000095691.1, ENSRNOT00000113145.2
    Conserved Domains (1) summary
    pfam00373
    Location:141 → 273
    FERM_M; FERM central domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    212572534..212593181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264380.1 → XP_063120450.1  FERM domain-containing protein 8 isoform X2

  2. XM_006230804.5 → XP_006230866.1  FERM domain-containing protein 8 isoform X1

    UniProtKB/TrEMBL
    A0A1B0GWW6
    Conserved Domains (2) summary
    smart00295
    Location:31 → 272
    B41; Band 4.1 homologues
    pfam00373
    Location:140 → 272
    FERM_M; FERM central domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2R3.1 GenPept UniProtKB/Swiss-Prot:Q5U2R3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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