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Wdr73 WD repeat domain 73 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308751, updated on 17-Aug-2024

Summary

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Official Symbol
Wdr73provided by RGD
Official Full Name
WD repeat domain 73provided by RGD
Primary source
RGD:1306429
See related
EnsemblRapid:ENSRNOG00000010664 AllianceGenome:RGD:1306429
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in cytoplasmic microtubule organization; negative regulation of apoptotic process; and nucleus organization. Predicted to colocalize with cleavage furrow; cytosol; and spindle pole. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 1. Orthologous to human WDR73 (WD repeat domain 73). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 55.0), Brain (RPKM 46.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q31
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (144269561..144277707, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (134860329..134868475, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142711955..142720292, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene IQ motif containing GTPase activating protein 1 Neighboring gene zinc finger and SCAN domain containing 2 Neighboring gene ribosomal protein L26-like 1, pseudogene 1 Neighboring gene neuromedin B Neighboring gene SEC11 homolog A, signal peptidase complex subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Loss-of-function mutations in WDR73 are responsible for microcephaly and steroid-resistant nephrotic syndrome: Galloway-Mowat syndrome. Colin E, et al. Am J Hum Genet, 2014 Dec 4. PMID 25466283, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic microtubule organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleus organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 73

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107525.2 → NP_001100995.1  WD repeat-containing protein 73

    Status: PROVISIONAL

    Source sequence(s)
    BC158658
    UniProtKB/TrEMBL
    B0BN27, F7EST6
    Related
    ENSRNOP00000029102.5, ENSRNOT00000032294.6
    Conserved Domains (2) summary
    COG2319
    Location:43 → 364
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:279 → 325
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    144269561..144277707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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