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Ttc23 tetratricopeptide repeat domain 23 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308708, updated on 10-Jul-2024

Summary

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Official Symbol
Ttc23provided by RGD
Official Full Name
tetratricopeptide repeat domain 23provided by RGD
Primary source
RGD:1310409
See related
EnsemblRapid:ENSRNOG00000013877 AllianceGenome:RGD:1310409
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310409
Summary
Predicted to be involved in positive regulation of smoothened signaling pathway. Predicted to be located in cilium. Orthologous to human TTC23 (tetratricopeptide repeat domain 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 62.4), Lung (RPKM 48.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ttc23 in Genome Data Viewer
Location:
1q22
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (130656040..130739670)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (121245996..121329500)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (128604324..128687900)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691157 Neighboring gene leucine rich repeat containing 28 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC108349234 Neighboring gene uncharacterized LOC120099844 Neighboring gene synemin Neighboring gene small ribosomal subunit protein eS27-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC116076

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in positive regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 23
Names
TPR repeat protein 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025681.1 → NP_001020852.2  tetratricopeptide repeat protein 23

    Status: VALIDATED

    Source sequence(s)
    BC097953
    UniProtKB/Swiss-Prot
    Q4V7F0
    Conserved Domains (2) summary
    sd00006
    Location:111 → 140
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:65 → 141
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    130656040..130739670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262554.1 → XP_063118624.1  tetratricopeptide repeat protein 23 isoform X3

    UniProtKB/Swiss-Prot
    Q4V7F0
    UniProtKB/TrEMBL
    F1LMW2

  2. XM_063262550.1 → XP_063118620.1  tetratricopeptide repeat protein 23 isoform X2

    UniProtKB/Swiss-Prot
    Q4V7F0
    UniProtKB/TrEMBL
    M0R9N4

  3. XM_017589157.3 → XP_017444646.1  tetratricopeptide repeat protein 23 isoform X2

    UniProtKB/Swiss-Prot
    Q4V7F0
    UniProtKB/TrEMBL
    M0R9N4
    Related
    ENSRNOP00000066210.2, ENSRNOT00000073355.4
    Conserved Domains (2) summary
    sd00006
    Location:102 → 131
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:202 → 269
    TPR_12; Tetratricopeptide repeat

  4. XM_008759516.4 → XP_008757738.1  tetratricopeptide repeat protein 23 isoform X2

    UniProtKB/Swiss-Prot
    Q4V7F0
    UniProtKB/TrEMBL
    M0R9N4
    Conserved Domains (2) summary
    sd00006
    Location:102 → 131
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:202 → 269
    TPR_12; Tetratricopeptide repeat

  5. XM_039112733.2 → XP_038968661.1  tetratricopeptide repeat protein 23 isoform X3

    UniProtKB/Swiss-Prot
    Q4V7F0
    UniProtKB/TrEMBL
    F1LMW2
    Related
    ENSRNOP00000018639.8, ENSRNOT00000018639.8
    Conserved Domains (1) summary
    pfam13424
    Location:202 → 269
    TPR_12; Tetratricopeptide repeat

  6. XM_063262570.1 → XP_063118640.1  tetratricopeptide repeat protein 23 isoform X6

  7. XM_039112738.2 → XP_038968666.1  tetratricopeptide repeat protein 23 isoform X4

    UniProtKB/Swiss-Prot
    Q4V7F0
    Conserved Domains (2) summary
    sd00006
    Location:87 → 116
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:187 → 254
    TPR_12; Tetratricopeptide repeat

  8. XM_039112740.2 → XP_038968668.1  tetratricopeptide repeat protein 23 isoform X4

    UniProtKB/Swiss-Prot
    Q4V7F0
    Conserved Domains (2) summary
    sd00006
    Location:87 → 116
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:187 → 254
    TPR_12; Tetratricopeptide repeat

  9. XM_063262551.1 → XP_063118621.1  tetratricopeptide repeat protein 23 isoform X2

    UniProtKB/Swiss-Prot
    Q4V7F0
    UniProtKB/TrEMBL
    M0R9N4

  10. XM_039112748.2 → XP_038968676.1  tetratricopeptide repeat protein 23 isoform X4

    UniProtKB/Swiss-Prot
    Q4V7F0
    Conserved Domains (2) summary
    sd00006
    Location:87 → 116
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:187 → 254
    TPR_12; Tetratricopeptide repeat

  11. XM_008759515.4 → XP_008757737.1  tetratricopeptide repeat protein 23 isoform X1

    UniProtKB/Swiss-Prot
    Q4V7F0
    UniProtKB/TrEMBL
    A0A0G2K6R3
    Related
    ENSRNOP00000073911.2, ENSRNOT00000078707.3
    Conserved Domains (2) summary
    sd00006
    Location:111 → 140
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:65 → 141
    TPR_12; Tetratricopeptide repeat

  12. XM_039112761.2 → XP_038968689.1  tetratricopeptide repeat protein 23 isoform X5

    Conserved Domains (1) summary
    pfam13424
    Location:145 → 215
    TPR_12; Tetratricopeptide repeat

RNA

  1. XR_010052154.1 RNA Sequence

  2. XR_010052152.1 RNA Sequence

  3. XR_005505567.2 RNA Sequence

  4. XR_005505570.2 RNA Sequence

  5. XR_005505569.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V7F0.1 GenPept UniProtKB/Swiss-Prot:Q4V7F0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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