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Cyfip1 cytoplasmic FMR1 interacting protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308666, updated on 28-Oct-2024

Summary

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Official Symbol
Cyfip1provided by RGD
Official Full Name
cytoplasmic FMR1 interacting protein 1provided by RGD
Primary source
RGD:1310332
See related
EnsemblRapid:ENSRNOG00000011945 AllianceGenome:RGD:1310332
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables RNA 7-methylguanosine cap binding activity. Involved in several processes, including cellular response to insulin stimulus; negative regulation of synaptic vesicle recycling; and positive regulation of cell projection organization. Located in several cellular components, including dendritic spine; distal axon; and filopodium tip. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autism spectrum disorder and schizophrenia. Orthologous to human CYFIP1 (cytoplasmic FMR1 interacting protein 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Lung (RPKM 305.6), Kidney (RPKM 283.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cyfip1 in Genome Data Viewer
Location:
1q22
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (115842754..115935163)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (106710924..106799393)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (114258773..114347138)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene NIPA magnesium transporter 1 Neighboring gene tubulin gamma complex component 5 Neighboring gene uncharacterized LOC134483327 Neighboring gene dynein light chain 1, cytoplasmic-like Neighboring gene U6 spliceosomal RNA Neighboring gene peroxiredoxin 3, pseudogene 1 Neighboring gene uncharacterized LOC108348727 Neighboring gene NIPA magnesium transporter 2 Neighboring gene uncharacterized LOC134483328

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Silva AI, et al. Nat Commun, 2019 Aug 1. PMID 31371763, Free PMC Article
  2. Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility. Haddon JE, et al. Transl Psychiatry, 2024 Jun 14. PMID 38876996, Free PMC Article
  3. The Prader-Willi phenotype of fragile X syndrome. Nowicki ST, et al. J Dev Behav Pediatr, 2007 Apr. PMID 17435464
  4. Up-regulated cytoplasmic FMRP-interacting protein 1 in intractable temporal lobe epilepsy patients and a rat model. Huang Y. Int J Neurosci, 2016 Jun. PMID 26000921
  5. Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice. Bozdagi O, et al. PLoS One, 2012. PMID 22900020, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility.
    Title: Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility.
  2. Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility.
    Title: Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility.
  3. Dysregulation of CYFIP1 expression levels leads to pathological changes in CNS maturation and neuronal connectivity, both of which may contribute to the development of the neurological symptoms seen in ASD and SCZ.
    Title: The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA 7-methylguanosine cap binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables translation repressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in axon extension ISO
Inferred from Sequence Orthology
more info
  
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cognition ISO
Inferred from Sequence Orthology
more info
  
involved_in dendrite extension ISO
Inferred from Sequence Orthology
more info
  
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in modification of synaptic structure IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in modification of synaptic structure ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of synaptic vesicle recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ruffle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of modification of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of myelination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translation at postsynapse, modulating synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in response to electrical stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of SCAR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCAR complex ISO
Inferred from Sequence Orthology
more info
  
located_in axonal growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in central region of growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendritic growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
located_in excitatory synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in filopodium tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in peripheral region of growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cytoplasmic FMR1-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107517.1 → NP_001100987.1  cytoplasmic FMR1-interacting protein 1

    See identical proteins and their annotated locations for NP_001100987.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474036
    UniProtKB/TrEMBL
    A6KD28, D4A8H8
    Related
    ENSRNOP00000016376.5, ENSRNOT00000016376.7
    Conserved Domains (1) summary
    pfam05994
    Location:389 → 1222
    FragX_IP; Cytoplasmic Fragile-X interacting family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    115842754..115935163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262343.1 → XP_063118413.1  cytoplasmic FMR1-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    A6KD28, D4A8H8

  2. XM_063262335.1 → XP_063118405.1  cytoplasmic FMR1-interacting protein 1 isoform X1

    Related
    ENSRNOP00000105554.1, ENSRNOT00000151113.1

  3. XM_039112486.2 → XP_038968414.1  cytoplasmic FMR1-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    A6KD28, D4A8H8
    Conserved Domains (1) summary
    pfam05994
    Location:389 → 1222
    FragX_IP; Cytoplasmic Fragile-X interacting family

  4. XM_006229288.4 → XP_006229350.1  cytoplasmic FMR1-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K472
    Related
    ENSRNOP00000072931.1, ENSRNOT00000088459.3
    Conserved Domains (1) summary
    pfam05994
    Location:389 → 1220
    FragX_IP; Cytoplasmic Fragile-X interacting family

  5. XM_039112492.1 → XP_038968420.1  cytoplasmic FMR1-interacting protein 1 isoform X4

    Conserved Domains (1) summary
    pfam05994
    Location:389 → 970
    FragX_IP; Cytoplasmic Fragile-X interacting family

  6. XM_039112494.1 → XP_038968422.1  cytoplasmic FMR1-interacting protein 1 isoform X5

    Conserved Domains (1) summary
    cl23945
    Location:389 → 695
    FragX_IP; Cytoplasmic Fragile-X interacting family
Nucleotide Protein Strain
Heading Accession and Version

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