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Hnrnph2 heterogeneous nuclear ribonucleoprotein H2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308650, updated on 10-Oct-2024

Summary

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Official Symbol
Hnrnph2provided by RGD
Official Full Name
heterogeneous nuclear ribonucleoprotein H2provided by RGD
Primary source
RGD:1549784
See related
EnsemblRapid:ENSRNOG00000011661 AllianceGenome:RGD:1549784
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hnrph2
Summary
Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Is active in postsynaptic density. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human HNRNPH2 (heterogeneous nuclear ribonucleoprotein H2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 320.1), Brain (RPKM 312.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hnrnph2 in Genome Data Viewer
Location:
Xq32
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (102074175..102080115)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (97780890..97786846)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (105417603..105423531)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36A Neighboring gene galactosidase, alpha Neighboring gene cytochrome c oxidase subunit 7B, pseudogene 2 Neighboring gene armadillo repeat containing, X-linked 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Alternative Splicing of Neuronal Differentiation Factor TRF2 Regulated by HNRNPH1/H2. Grammatikakis I, et al. Cell Rep, 2016 May 3. PMID 27117401, Free PMC Article
  2. hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc. Mauger DM, et al. Mol Cell Biol, 2008 Sep. PMID 18573884, Free PMC Article
  3. Proteomics analysis of rat brain postsynaptic density. Implications of the diverse protein functional groups for the integration of synaptic physiology. Li KW, et al. J Biol Chem, 2004 Jan 9. PMID 14532281
  4. Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Maggi LB Jr, et al. Mol Cell Biol, 2008 Dec. PMID 18809582, Free PMC Article
  5. Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Hoffert JD, et al. Proc Natl Acad Sci U S A, 2006 May 2. PMID 16641100, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein H2
Names
heterogeneous nuclear ribonucleoprotein H'
heterogeneous nuclear ribonucleoprotein H2 (H')
hnRNP H'
hnRNP H2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014019.1 → NP_001014041.1  heterogeneous nuclear ribonucleoprotein H2

    See identical proteins and their annotated locations for NP_001014041.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079240
    UniProtKB/Swiss-Prot
    Q6AY09
    UniProtKB/TrEMBL
    A6IVG4, G3V9Q3
    Related
    ENSRNOP00000015518.3, ENSRNOT00000015518.6
    Conserved Domains (4) summary
    pfam08080
    Location:257 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    102074175..102080115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279968.1 → XP_063136038.1  heterogeneous nuclear ribonucleoprotein H2 isoform X1

    UniProtKB/Swiss-Prot
    Q6AY09
    UniProtKB/TrEMBL
    A6IVG4

  2. XM_006257220.5 → XP_006257282.1  heterogeneous nuclear ribonucleoprotein H2 isoform X1

    See identical proteins and their annotated locations for XP_006257282.1

    UniProtKB/Swiss-Prot
    Q6AY09
    UniProtKB/TrEMBL
    A6IVG4, G3V9Q3
    Related
    ENSRNOP00000096745.1, ENSRNOT00000119849.2
    Conserved Domains (4) summary
    pfam08080
    Location:257 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  3. XM_006257219.5 → XP_006257281.1  heterogeneous nuclear ribonucleoprotein H2 isoform X1

    See identical proteins and their annotated locations for XP_006257281.1

    UniProtKB/Swiss-Prot
    Q6AY09
    UniProtKB/TrEMBL
    A6IVG4, G3V9Q3
    Conserved Domains (4) summary
    pfam08080
    Location:257 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  4. XM_006257221.4 → XP_006257283.1  heterogeneous nuclear ribonucleoprotein H2 isoform X1

    See identical proteins and their annotated locations for XP_006257283.1

    UniProtKB/Swiss-Prot
    Q6AY09
    UniProtKB/TrEMBL
    A6IVG4, G3V9Q3
    Conserved Domains (4) summary
    pfam08080
    Location:257 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AY09.1 GenPept UniProtKB/Swiss-Prot:Q6AY09

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