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Dmpk DM1 protein kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 308405, updated on 10-Oct-2024

Summary

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Official Symbol
Dmpkprovided by RGD
Official Full Name
DM1 protein kinaseprovided by RGD
Primary source
RGD:1309825
See related
EnsemblRapid:ENSRNOG00000015085 AllianceGenome:RGD:1309825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dm15
Summary
Predicted to enable ATP binding activity; myosin phosphatase regulator activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including muscle cell apoptotic process; regulation of skeletal muscle contraction by calcium ion signaling; and regulation of synapse structural plasticity. Predicted to act upstream of or within regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction and regulation of sodium ion transport. Located in membrane. Human ortholog(s) of this gene implicated in myotonic dystrophy type 1. Orthologous to human DMPK (DM1 protein kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 649.4), Heart (RPKM 490.8) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dmpk in Genome Data Viewer
Location:
1q21
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (87858294..87868624)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (78730255..78740585)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (79988096..79999358)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene jupiter microtubule associated homolog 1-like Neighboring gene radial spoke head 6 homolog A Neighboring gene uncharacterized LOC108349062 Neighboring gene DM1 locus, WD repeat containing Neighboring gene SIX homeobox 5 Neighboring gene meiosis initiator Neighboring gene F-box protein 46

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Myotonic dystrophy CTG repeat expansion alters Ca2+ channel functional expression in PC12 cells. Andrade A, et al. FEBS Lett, 2007 Sep 18. PMID 17719582
  2. The MEF2 transcriptional target DMPK induces loss of sarcomere structure and cardiomyopathy. Damanafshan A, et al. Cardiovasc Res, 2018 Sep 1. PMID 29648621
  3. A role for myotonic dystrophy protein kinase in synaptic plasticity. Schulz PE, et al. J Neurophysiol, 2003 Mar. PMID 12612014
  4. Myotonic dystrophy protein kinase domains mediate localization, oligomerization, novel catalytic activity, and autoinhibition. Bush EW, et al. Biochemistry, 2000 Jul 25. PMID 10913253
  5. Myotonic dystrophy protein kinase is involved in the modulation of the Ca2+ homeostasis in skeletal muscle cells. Benders AA, et al. J Clin Invest, 1997 Sep 15. PMID 9294109, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MEF2-induced loss of sarcomeres is mediated by DMPK via a decrease in sarcomeric gene expression by interfering with SRF transcriptional activity, leading to adverse cardiomyocyte remodelling and heart failure.
    Title: The MEF2 transcriptional target DMPK induces loss of sarcomere structure and cardiomyopathy.
  2. DMPK peptides were identified by high-resolution mass spectrometry together with several putative DMPK-binding proteins, including several heat shock proteins such as HSP20/HSPB6, HSP60/CPN60, HSP70 and HSP90.
    Title: Mass spectrometry analysis of complexes formed by myotonic dystrophy protein kinase (DMPK).
  3. Data suggest modifications in the processing of N-type Ca(2+) channels in PC12 cells expressing the DM1 mutation.
    Title: Myotonic dystrophy CTG repeat expansion alters Ca2+ channel functional expression in PC12 cells.
  4. DMPK phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum
    Title: Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear envelope organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear envelope organization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of heart contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of myotube differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of skeletal muscle contraction by calcium ion signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of skeletal muscle contraction by calcium ion signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synapse structural plasticity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sarcoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myotonin-protein kinase
Names
dystrophia myotonica kinase, B15
dystrophia myotonica-protein kinase
NP_001358993.1
NP_001402776.1
NP_001402777.1
NP_001402778.1
XP_008757271.1
XP_017445484.1
XP_038967160.1
XP_038967163.1
XP_038967182.1
XP_038967184.1
XP_038967186.1
XP_063117378.1
XP_063117379.1
XP_063117382.1
XP_063117383.1
XP_063117389.1
XP_063117390.1
XP_063117394.1
XP_063117399.1
XP_063117400.1
XP_063117402.1
XP_063117403.1
XP_063117406.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372064.1 → NP_001358993.1  myotonin-protein kinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    FQ235737, JAXUCZ010000001
    UniProtKB/TrEMBL
    D3ZYV4
    Related
    ENSRNOP00000020428.9, ENSRNOT00000020428.10
    Conserved Domains (2) summary
    pfam08826
    Location:472 → 532
    DMPK_coil; DMPK coiled coil domain like
    cl21453
    Location:69 → 406
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001415847.1 → NP_001402776.1  myotonin-protein kinase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  3. NM_001415848.1 → NP_001402777.1  myotonin-protein kinase isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    Related
    ENSRNOP00000067795.3, ENSRNOT00000071916.5

  4. NM_001415849.1 → NP_001402778.1  myotonin-protein kinase isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    87858294..87868624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261309.1 → XP_063117379.1  myotonin-protein kinase isoform X2

    Related
    ENSRNOP00000109310.1, ENSRNOT00000150391.1

  2. XM_063261308.1 → XP_063117378.1  myotonin-protein kinase isoform X1

    Related
    ENSRNOP00000095056.2, ENSRNOT00000105612.2

  3. XM_039111254.1 → XP_038967182.1  myotonin-protein kinase isoform X10

    UniProtKB/TrEMBL
    A6J8J5
    Conserved Domains (2) summary
    pfam08826
    Location:472 → 532
    DMPK_coil; DMPK coiled coil domain like
    cl21453
    Location:69 → 406
    PKc_like; Protein Kinases, catalytic domain

  4. XM_039111232.1 → XP_038967160.1  myotonin-protein kinase isoform X5

    UniProtKB/TrEMBL
    A0A8I6ANX6
    Conserved Domains (2) summary
    pfam08826
    Location:472 → 532
    DMPK_coil; DMPK coiled coil domain like
    cl21453
    Location:69 → 406
    PKc_like; Protein Kinases, catalytic domain

  5. XM_039111256.2 → XP_038967184.1  myotonin-protein kinase isoform X13

    UniProtKB/TrEMBL
    A6J8J5
    Conserved Domains (3) summary
    pfam08826
    Location:472 → 532
    DMPK_coil; DMPK coiled coil domain like
    NF033885
    Location:439 → 566
    conj_TraP_IncI1; conjugal transfer protein TraP
    cl21453
    Location:69 → 406
    PKc_like; Protein Kinases, catalytic domain

  6. XM_017589995.2 → XP_017445484.1  myotonin-protein kinase isoform X8

    UniProtKB/TrEMBL
    D3ZYV4

  7. XM_063261313.1 → XP_063117383.1  myotonin-protein kinase isoform X4

  8. XM_063261312.1 → XP_063117382.1  myotonin-protein kinase isoform X3

  9. XM_063261324.1 → XP_063117394.1  myotonin-protein kinase isoform X11

  10. XM_039111235.1 → XP_038967163.1  myotonin-protein kinase isoform X6

    UniProtKB/TrEMBL
    A0A8I6ANX6
    Conserved Domains (2) summary
    pfam08826
    Location:467 → 527
    DMPK_coil; DMPK coiled coil domain like
    cl21453
    Location:69 → 401
    PKc_like; Protein Kinases, catalytic domain

  11. XM_063261329.1 → XP_063117399.1  myotonin-protein kinase isoform X15

  12. XM_063261320.1 → XP_063117390.1  myotonin-protein kinase isoform X9

  13. XM_063261330.1 → XP_063117400.1  myotonin-protein kinase isoform X16

  14. XM_063261319.1 → XP_063117389.1  myotonin-protein kinase isoform X7

  15. XM_008759049.3 → XP_008757271.1  myotonin-protein kinase isoform X12

    See identical proteins and their annotated locations for XP_008757271.1

    UniProtKB/TrEMBL
    A6J8J5
    Conserved Domains (3) summary
    pfam08826
    Location:472 → 532
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71 → 339
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:69 → 406
    PKc_like; Protein Kinases, catalytic domain

  16. XM_039111258.1 → XP_038967186.1  myotonin-protein kinase isoform X14

    UniProtKB/TrEMBL
    A6J8J5
    Conserved Domains (2) summary
    pfam08826
    Location:472 → 532
    DMPK_coil; DMPK coiled coil domain like
    cl21453
    Location:69 → 406
    PKc_like; Protein Kinases, catalytic domain

  17. XM_063261336.1 → XP_063117406.1  myotonin-protein kinase isoform X19

  18. XM_063261333.1 → XP_063117403.1  myotonin-protein kinase isoform X18

  19. XM_063261332.1 → XP_063117402.1  myotonin-protein kinase isoform X17

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107484.1: Suppressed sequence

    Description
    NM_001107484.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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