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Fbxw4 F-box and WD-40 domain protein 4 [ Mus musculus (house mouse) ]

Gene ID: 30838, updated on 2-Nov-2024

Summary

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Official Symbol
Fbxw4provided by MGI
Official Full Name
F-box and WD-40 domain protein 4provided by MGI
Primary source
MGI:MGI:1354698
See related
Ensembl:ENSMUSG00000040913 AllianceGenome:MGI:1354698
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dac; Fbw4; SHFM3; SHSF3; dactylin; dactylyn
Summary
Acts upstream of or within cartilage development; embryonic digit morphogenesis; and positive regulation of mesenchymal cell proliferation. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in brain; diencephalon roof plate; midbrain ventricular layer; and midbrain-hindbrain junction. Orthologous to human FBXW4 (F-box and WD repeat domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 14.9), ovary adult (RPKM 14.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fbxw4 in Genome Data Viewer
Location:
19 C3; 19 38.75 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45566693..45648954, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45578254..45660520, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41856 Neighboring gene predicted gene, 19639 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:45634643-45634844 Neighboring gene STARR-positive B cell enhancer ABC_E9999 Neighboring gene polymerase (DNA directed), lambda Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:45652022-45652175 Neighboring gene deleted in primary ciliary dyskinesia Neighboring gene AmnSINE1 enhancer AS071 Neighboring gene STARR-seq mESC enhancer starr_46281 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:45758150-45758404 Neighboring gene CR4 enhancer downstream of Fgf8 Neighboring gene RIKEN cDNA 4933429K18 gene Neighboring gene CR2 enhancer downstream of Fgf8 Neighboring gene Fgf8 enhancer CR1 Neighboring gene fibroblast growth factor 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proviral insertions in the zebrafish hagoromo gene, encoding an F-box/WD40-repeat protein, cause stripe pattern anomalies. Kawakami K, et al. Curr Biol, 2000 Apr 20. PMID 10801422
  2. Characterization of mouse Dactylaplasia mutations: a model for human ectrodactyly SHFM3. Friedli M, et al. Mamm Genome, 2008 Apr. PMID 18392654
  3. Dactylaplasia in mice a two-locus model for development anomalies. Chai CK. J Hered, 1981 Jul-Aug. PMID 7288137
  4. Pathogenesis of ectrodactyly in the Dactylaplasia mouse: aberrant cell death of the apical ectodermal ridge. Seto ML, et al. Teratology, 1997 Oct. PMID 9408977
  5. Genetically regulated epigenetic transcriptional activation of retrotransposon insertion confers mouse dactylaplasia phenotype. Kano H, et al. Proc Natl Acad Sci U S A, 2007 Nov 27. PMID 17984064, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dactylaplasia in mouse is not associated with duplication of Fbxw4, in contrast with the described human cases.
    Title: Characterization of mouse Dactylaplasia mutations: a model for human ectrodactyly SHFM3.
  2. Both dactylaplasia-related Dac insertions are caused by a type D mouse endogenous provirus (MusD) element, which can be silenced by Mda.
    Title: Genetically regulated epigenetic transcriptional activation of retrotransposon insertion confers mouse dactylaplasia phenotype.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within limb development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within limb development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
F-box/WD repeat-containing protein 4
Names
F-box and WD-40 domain-containing protein 4
F-box protein Fbw4
dactylaplasia
protein hagoromo

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013907.3 → NP_038935.2  F-box/WD repeat-containing protein 4

    Status: VALIDATED

    Source sequence(s)
    AC126454, AC140332
    Consensus CDS
    CCDS29863.1

RNA

  1. NR_182263.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC126454, AC140332

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    45566693..45648954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527131.5 → XP_006527194.1  F-box/WD repeat-containing protein 4 isoform X1

    Conserved Domains (3) summary
    sd00039
    Location:303 → 335
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:165 → 206
    F-box-like
    cl29593
    Location:294 → 534
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_011247258.4 → XP_011245560.1  F-box/WD repeat-containing protein 4 isoform X2

    Conserved Domains (3) summary
    sd00039
    Location:303 → 335
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:165 → 206
    F-box-like
    cl29593
    Location:245 → 460
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_011247261.4 → XP_011245563.1  F-box/WD repeat-containing protein 4 isoform X4

    Conserved Domains (2) summary
    sd00039
    Location:119 → 155
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:65 → 304
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_011247259.4 → XP_011245561.1  F-box/WD repeat-containing protein 4 isoform X3

    Conserved Domains (3) summary
    sd00039
    Location:303 → 335
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:165 → 206
    F-box-like
    cl29593
    Location:291 → 391
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_386482.5 RNA Sequence

  2. XR_877675.4 RNA Sequence

    Related
    ENSMUST00000046869.11

  3. XR_001782592.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JMJ2.1 GenPept UniProtKB/Swiss-Prot:Q9JMJ2

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