CD209 CD209 molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD209provided by HGNC
Official Full Name: CD209 moleculeprovided by HGNC
Primary source: HGNC:HGNC:1641
See related: Ensembl:ENSG00000090659 MIM:604672; AllianceGenome:HGNC:1641
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; hDC-SIGN
Summary: This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity. [provided by RefSeq, May 2020]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Expression: Broad expression in placenta (RPKM 11.4), lymph node (RPKM 9.5) and 17 other tissues See more
Orthologs: all
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Genomic context

Location:: 19p13.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (7739993..7747534, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (7741021..7748561, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (7804879..7812420, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SARS-CoV-2 suppresses TLR4-induced immunity by dendritic cells via C-type lectin receptor DC-SIGN.
Title: SARS-CoV-2 suppresses TLR4-induced immunity by dendritic cells via C-type lectin receptor DC-SIGN.
DC-SIGN and Galectin-3 individually and collaboratively regulate H5N1 and H7N9 avian influenza A virus infection via interaction with viral envelope hemagglutinin protein.
Title: DC-SIGN and Galectin-3 individually and collaboratively regulate H5N1 and H7N9 avian influenza A virus infection via interaction with viral envelope hemagglutinin protein.
Importance of NFkappabeta, IL-10 serum levels and DC-SIGN polymorphic haplotypes in determining dengue disease severity among eastern Indian patients.
Title: Importance of NFκβ, IL-10 serum levels and DC-SIGN polymorphic haplotypes in determining dengue disease severity among eastern Indian patients.
Genetic polymorphisms in TLR3, IL10 and CD209 influence the risk of BK polyomavirus infection after kidney transplantation.
Title: Genetic polymorphisms in TLR3, IL10 and CD209 influence the risk of BK polyomavirus infection after kidney transplantation.
Association of CD209 (DC-SIGN) rs735240 SNV with paucibacillary leprosy in the Brazilian population and its functional effects.
Title: Association of CD209 (DC-SIGN) rs735240 SNV with paucibacillary leprosy in the Brazilian population and its functional effects.
CD209/CD14(+) Dendritic Cells Characterization in Rheumatoid and Psoriatic Arthritis Patients: Activation, Synovial Infiltration, and Therapeutic Targeting.
Title: CD209/CD14(+) Dendritic Cells Characterization in Rheumatoid and Psoriatic Arthritis Patients: Activation, Synovial Infiltration, and Therapeutic Targeting.
Suppression of DC-SIGN and gH Reveals Complex, Subset-Specific Mechanisms for KSHV Entry in Primary B Lymphocytes.
Title: Suppression of DC-SIGN and gH Reveals Complex, Subset-Specific Mechanisms for KSHV Entry in Primary B Lymphocytes.
The differentiation of new human CD303(+) Plasmacytoid dendritic cell subpopulations expressing CD205 and/or CD103 regulated by Non-Small-Cell lung cancer cells.
Title: The differentiation of new human CD303(+) Plasmacytoid dendritic cell subpopulations expressing CD205 and/or CD103 regulated by Non-Small-Cell lung cancer cells.
DC-SIGN Mediates the Interaction Between Neutrophils and Leishmania amazonensis-Infected Dendritic Cells to Promote DC Maturation and Parasite Elimination.
Title: DC-SIGN Mediates the Interaction Between Neutrophils and Leishmania amazonensis-Infected Dendritic Cells to Promote DC Maturation and Parasite Elimination.
Association of single nucleotide polymorphisms in the CD209, MMP9, TNFA and IFNG genes with susceptibility to Japanese encephalitis in children from North India.
Title: Association of single nucleotide polymorphisms in the CD209, MMP9, TNFA and IFNG genes with susceptibility to Japanese encephalitis in children from North India.

Submit: New GeneRIF Correction See all GeneRIFs (304)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Dengue virus, susceptibility to MedGen: C3280582 OMIM: 614371 GeneReviews: Not available	Compare labs
Mycobacterium tuberculosis, susceptibility to MedGen: C1834752 OMIM: 607948 GeneReviews: Not available	Compare labs
Susceptibility to HIV infection MedGen: C1836230 OMIM: 609423 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Latent HIV infection is activated by HIV-1 Env (gp120) binding to CD209 (DC-SIGN)	PubMed
Knockdown of DC-SIGN (CD209) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 SF162 or LAI Env (gp140) binds to CD209 (DC-SIGN)	PubMed
	env	HIV-1 Env (gp120) binds to CD209 (DC-SIGN), which induces NFKB1 (NF-kB), MAPK1 (ERK1/2), and MAPK14 (p38)	PubMed
	env	HIV-1 JRFL and HXB2 (gp120) binds CD209 (DC-SIGN)	PubMed
	env	A dendritic cells (DC)-specific C-type lectin, DC-SIGN, is highly expressed on DC present in mucosal tissues, binds to the HIV-1 envelope glycoprotein gp120, and facilitates infection of HIV-1 permissive cells in trans	PubMed
	env	HIV-1 Env gp120/41 (JRFL Env in the contaxt of HIV-Gag-GFP VLP) binds to CD209 (DC-SIGN) on the surface of basophils	PubMed
	env	The N-terminal DC-SIGN CRD region (residues 253-288) is essential for HIV-1 binding and transmission and Y258 is required for these activities, suggesting the N-terminal CRD region involves the interaction of DC-SIGN with gp120	PubMed
	env	Natural antibodies against the carbohydrate recognition domain (CRD) of DC-SIGN block the attachment of HIV-1 to DC-SIGN-positive cells and inhibit transmission in trans of HIV-1 to T cells, suggesting the CRD is important for its interaction with gp120	PubMed
	env	Binding of HIV-1 gp120 to DC-SIGN leads to excessive ASK-1 activation and promotes ASK-1-dependent apoptosis in human dendritic cells	PubMed
	env	Binding of HIV-1 gp120 to DC-SIGN sensitizes monocyte-derived dendritic cells for CD40L-mediated apoptosis	PubMed
	env	HIV-1 gp120 downregulates HIV-1 Nef dependent IL-6 release, which requires the interaction of gp120 with DC-SIGN in immature dentritic cells	PubMed
	env	CD4-linker-DC-SIGN fusion proteins enhance binding affinity to HIV-1 gp140 and gp120 in comparison to sCD4 and sDC-SIGN. These fusion proteins inhibit HIV-1 capture and transfer via DC-SIGN-expressing cells and iMDDCs	PubMed
	env	DC-SIGN is strongly upregulated in M2a-polarized monocyte-derived-macrophages (MDMs), which leads to facilitate HIV-1 entry via gp120/gp41 and DNA synthesis in M2a-MDMs and to efficiently transmit both R5 and X4 HIV-1 to CD4+ T cells	PubMed
	env	Enrichment of oligomannose N-glycans on HIV-1 gp120 enhances DC-SIGN binding but reduces the subsequent transmission to target cells	PubMed
	env	DC-SIGN engagement by HIV-1 gp120 on dendritic cell (DC) surface subsequently activates Cdc42, Pak1, and Wasp, leading to an increase in membrane extensions at the DC surface	PubMed
	env	AM3 (Inmunoferon) inhibits the interaction of DC-SIGN with both ICAM3 and HIV-1 gp120 protein and blocks the DC-SIGN-dependent capture of HIV virions and the HIV trans-infection capability of DC-SIGN transfectants	PubMed
	env	Raji-DC-SIGN cells preferentially enhance CXCR4 usage of dual-tropic HIV-1 with higher V3 charges in gp120	PubMed
	env	DC-SIGN triacidic cluster (353EEE355) mutant is impaired in receptor-mediated endocytosis of HIV-1 gp120 in transfected human myeloid K-562 cells	PubMed
	env	One HIV-1 gp120 triple glycosylation mutant form 134mut (carrying N293Q, N382Q, and N388Q mutations in gp120) exhibits a significant increase in sensitivity to both mannan competition and endoglycosidase H digestion in a DC-SIGN binding assay	PubMed
	env	Mermaid shares glycan specificity with DC-SIGN and inhibits the interaction between DC-SIGN and HIV-1 gp120	PubMed
	env	Oligomannose glycans play as ligands for DC-SIGN, and can inhibit the binding of gp120 to 2G12 and recombinant dimeric DC-SIGN	PubMed
	env	End-stage CCR5-tropic HIV-1 have a reduced ability to use DC-SIGN resulting from the loss of potential N-linked glycosylation sites (PNGS) in the gp120 V2 and V4 regions, which are present in the majority of chronic stage CCR5-tropic variants	PubMed
	env	Expression of CD4 on Raji B cells strongly inhibits DC-SIGN-mediated HIV-1 (gp120) transmission to T cells; co-expression of CD4 and DC-SIGN in Raji cells promotes internalization and intracellular retention of HIV-1	PubMed
	env	Monoclonal antibodies produced from hybridoma clones recognize DC-SIGN on monocyte-derived dendritic cells and on dermal-type macrophages to interfere with DC-SIGN binding to HIV-1 gp120	PubMed
	env	Glycopolymers effectively prevent the interactions between a human dendritic cell associated lectin (DC-SIGN) and the HIV-1 gp120	PubMed
	env	HIV-1 gp120 N275Q or N351Q mutants isolated from recombinant CRF07_BC decrease significantly to the DC-SIGN-binding capacity, indicating that the N275 and N351 glycan sites mediate the interaction between CRF07_BC gp120 and DC-SIGN	PubMed
	env	Using an siRNA approach indicates DC-SIGN is not required for efficient trans-enhancement of HIV-1 (gp120) infectivity by dendritic cells (DCs)	PubMed
	env	Bile salt-stimulated lipase (BSSL) isolated from human milk binds to DC-SIGN, preventing HIV-1 gp120 from interacting with this receptor	PubMed
	env	HIV-1 gp120 binds to B cells through mannose C-type lectin receptors (MCLRs), such as DC-SIGN, mannose receptor, and langerin	PubMed
	env	Interaction of gp120 with DC-SIGN activates Raf-1 and phosphorylates Raf-1 at positions Ser338, Tyr340, and Tyr341	PubMed
	env	DC-SIGN-mediated blockage of HIV budding is due to internalization of gp120 by DC-SIGN. The 364 amino-acid residues of extracellular and transmembrane domains in DC-SIGN are essential for the blockage	PubMed
	env	Human milk oligosaccharides reduce HIV-1-gp120 binding to dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN)	PubMed
	env	Crystal structures of carbohydrate-recognition domains of DC-SIGN and of DC-SIGNR in combination with binding studies reveal that these receptors selectively recognize endogenous high-mannose oligosaccharides of HIV-1 gp120	PubMed
	env	The cis expression of DC-SIGN on multiple lymphoid cell lines enables more efficient entry and replication of CXCR4-tropic and CCR5/CXCR4 dual-tropic HIV-1 through its binding to the HIV-1 gp120-CD4-CXCR4 complex	PubMed
	env	Bovine lactoferrin (bLF) binds strongly to DC-SIGN, thus blocking the interaction between DC-SIGN and HIV-1 gp120 and preventing virus capture and subsequent transmission; bLF is a much more efficient inhibitor of transmission than human lactoferrin	PubMed
	env	Binding of HIV-1 gp120 to DC-SIGN does not result in increased adhesion levels of LFA-1 to its ligand ICAM-1 in both immature dendritic cells (DC) and Raji-DC-SIGN cells	PubMed
	env	DC-SIGN tetramers are essential for high affinity interactions with the HIV-1 high mannose glycoprotein gp120	PubMed
	env	Mutagenesis of conserved residues (Gly-346, Glu-347, Asn-349, Glu-354, and Asp-355) of DC-SIGN significantly compromises binding to HIV-1 gp120	PubMed
	env	DC-SIGN and MBL bind primarily to glycans on HIV-1 gp120/gp41; preincubation of CXCR4-, CCR5- or dual-tropic HIV-1 strains with MBL prevents DC-SIGN-mediated trans infection of T cells	PubMed
	env	The HIV-1 gp120 binding site in DC-SIGN is different from that of ICAM-2 and ICAM-3; alanine-scanning mutagenesis of DC-SIGN at N311, R345, V351, G352, E353, S360, G361, and N362 abrogate ICAM-2/3 binding, whereas the HIV-1 gp120 interaction is unaffected	PubMed
Envelope surface glycoprotein gp160, precursor	env	Colorectal mucus binds DC-SIGN, which prevents HIV-1 gp140 from binding to DC-SIGN	PubMed
	env	CD4-linker-DC-SIGN fusion proteins enhance binding affinity to HIV-1 gp140 and gp120 in comparison to sCD4 and sDC-SIGN. These fusion proteins inhibit HIV-1 capture and transfer via DC-SIGN-expressing cells and iMDDCs	PubMed
	env	Enrichment of oligomannose N-glycans on HIV-1 gp140 enhances DC-SIGN binding but reduces the subsequent transmission to target cells	PubMed
	env	DC-SIGN binding to the HIV envelope protein effectively increases exposure of the CD4 binding site, which leads to enhance the relative rate of infection of the CD4-dependent strain	PubMed
	env	DC-SIGN increases the binding affinity of trimeric gp140 envelope glycoproteins to CD4 on permissive cell surface	PubMed
Nef	nef	HIV-1 gp120 downregulates HIV-1 Nef dependent IL-6 release, which requires the interaction of gp120 with DC-SIGN in immature dentritic cells	PubMed
	nef	Mutation of the dileucine motif at amino acids 165-166 of HIV-1 Nef abolishes the Nef-mediated upregulation of DC-SIGN on the surface of HIV-1 infected dendritic cells	PubMed
	nef	HIV-1 Nef upregulates DC-SIGN in HIV-1 infected dendritic cells by inhibiting DC-SIGN endocytosis, which dramatically increases clustering of dendritic cells with T lymphocytes, thereby enhancing HIV-1 transmission	PubMed
	nef	Substitution of HIV-1 Nef acidic residue E160 with uncharged residues impairs the ability of Nef to upregulate the expression of DC-SIGN and the invariant chain of MHC class II at the cell surface	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-149275 (e-PCR)
- UniSTS:176900

PMC156606P1 (e-PCR)
- UniSTS:271408

D8S2279 (e-PCR)
- UniSTS:473907

CD209_523 (e-PCR)
- UniSTS:277070

RH98479 (e-PCR)
- UniSTS:92273

D1S1423 (e-PCR)
- UniSTS:149619

STS-AA028127 (e-PCR)
- UniSTS:82341

PMC114396P1 (e-PCR)
- UniSTS:270265

NoName (e-PCR)
- UniSTS:481741

NoName (e-PCR)
- UniSTS:482545

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables carbohydrate binding	NAS Non-traceable Author Statement more info	PubMed
enables mannose binding	IBA Inferred from Biological aspect of Ancestor more info
enables mannose binding	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide antigen binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables virion binding	TAS Traceable Author Statement more info	PubMed
enables virus receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in antigen processing and presentation	NAS Non-traceable Author Statement more info	PubMed
involved_in biological process involved in interspecies interaction between organisms	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell recognition	TAS Traceable Author Statement more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	TAS Traceable Author Statement more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in intracellular transport of virus	TAS Traceable Author Statement more info	PubMed
involved_in leukocyte cell-cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in peptide antigen transport	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of viral life cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in symbiont entry into host cell	IDA Inferred from Direct Assay more info	PubMed
involved_in viral genome replication	NAS Non-traceable Author Statement more info	PubMed
involved_in virion attachment to host cell	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	HDA more info	PubMed
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in host cell	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: CD209 antigen

Names: C-type lectin domain family 4 member L; HIV gpl20-binding protein; dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012167.1 RefSeqGene

Range

5045..12586

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001144893.2 → NP_001138365.1 CD209 antigen isoform 5

See identical proteins and their annotated locations for NP_001138365.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 5, which is shorter than isoform 1. The encoded isoform (5) lacks the transmembrane domain and has 4.5 repeats in the neck domain.

Source sequence(s)

AC008763, AK313585, AY042227

Consensus CDS

CCDS59344.1

UniProtKB/TrEMBL

M0R0P0

Related

ENSP00000471348.1, ENST00000593821.5

Conserved Domains (2) summary

cd03590
Location:120 → 243

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam05816
Location:31 → 116

TelA; Toxic anion resistance protein (TelA)
NM_001144894.2 → NP_001138366.1 CD209 antigen isoform 6

See identical proteins and their annotated locations for NP_001138366.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks multiple exons in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter and lacks the transmembrane domain compared to isoform 1.

Source sequence(s)

AC008763, AK313585, AY042226

Consensus CDS

CCDS45949.1

UniProtKB/TrEMBL

B2R907

Related

ENSP00000204801.7, ENST00000204801.12

Conserved Domains (1) summary

cd03590
Location:212 → 335

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
NM_001144895.2 → NP_001138367.1 CD209 antigen isoform 7

See identical proteins and their annotated locations for NP_001138367.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 7) compared to isoform 1. The encoded isoform (7) has 4.5 repeats in the neck domain.

Source sequence(s)

AC008763, AK313585, AY042223

Consensus CDS

CCDS45952.1

UniProtKB/TrEMBL

M0QZG5

Related

ENSP00000471137.1, ENST00000602261.5

Conserved Domains (2) summary

cd03590
Location:164 → 287

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

pfam05816
Location:75 → 160

TelA; Toxic anion resistance protein (TelA)
NM_001144896.2 → NP_001138368.1 CD209 antigen isoform 3

See identical proteins and their annotated locations for NP_001138368.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter and lacks the transmembrane domain compared to isoform 1.

Source sequence(s)

AC008763, AK313585, AY042225

Consensus CDS

CCDS45950.1

UniProtKB/TrEMBL

B2R907

Related

ENSP00000315407.7, ENST00000315591.12

Conserved Domains (1) summary

cd03590
Location:232 → 355

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
NM_001144897.2 → NP_001138369.1 CD209 antigen isoform 4

See identical proteins and their annotated locations for NP_001138369.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 4) compared to isoform 1.

Source sequence(s)

AC008763, AK313585, AY042222

Consensus CDS

CCDS45951.1

UniProtKB/TrEMBL

B2R907

Related

ENSP00000346373.5, ENST00000354397.10

Conserved Domains (2) summary

cd03590
Location:256 → 373

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

cl01234
Location:38 → 184

PilO; Pilus assembly protein, PilO
NM_001144899.2 → NP_001138371.1 CD209 antigen isoform 8

Status: REVIEWED

Description

Transcript Variant: This variant (8) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 8) compared to isoform 1. The encoded isoform (8) has 1.5 repeats in the neck domain.

Source sequence(s)

AC008763, AK304190

Consensus CDS

CCDS59345.1

UniProtKB/TrEMBL

X6RB12

Related

ENSP00000377728.4, ENST00000394173.8

Conserved Domains (1) summary

cd03590
Location:95 → 218

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
NM_021155.4 → NP_066978.1 CD209 antigen isoform 1

See identical proteins and their annotated locations for NP_066978.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC008763, AK313585, AY042221

Consensus CDS

CCDS12186.1

UniProtKB/Swiss-Prot

A8KAM4, A8MVQ9, G5E9C4, Q2TB19, Q96QP7, Q96QP8, Q96QP9, Q96QQ0, Q96QQ1, Q96QQ2, Q96QQ3, Q96QQ4, Q96QQ5, Q96QQ6, Q96QQ7, Q96QQ8, Q9NNX6

UniProtKB/TrEMBL

B2R907

Related

ENSP00000315477.6, ENST00000315599.12

Conserved Domains (2) summary

cd03590
Location:256 → 379

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

cl01234
Location:38 → 184

PilO; Pilus assembly protein, PilO

RNA

NR_026692.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC008763, AK313585, AY042229