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Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308267, updated on 2-Nov-2024

Summary

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Official Symbol
Tab2provided by RGD
Official Full Name
TGF-beta activated kinase 1/MAP3K7 binding protein 2provided by RGD
Primary source
RGD:1309527
See related
EnsemblRapid:ENSRNOG00000016054 AllianceGenome:RGD:1309527
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Map3k7ip2
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity; molecular adaptor activity; and zinc ion binding activity. Predicted to be involved in several processes, including non-canonical NF-kappaB signal transduction; positive regulation of canonical NF-kappaB signal transduction; and response to bacterium. Predicted to be located in cytosol; endosome membrane; and lysosomal membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in cardiomyopathy; congenital heart disease; and ovary epithelial cancer. Orthologous to human TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 106.9), Thymus (RPKM 102.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tab2 in Genome Data Viewer
Location:
1p13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (4195400..4245485, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (2375026..2425115, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (1999574..2017574, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase like 4 Neighboring gene zinc finger CCCH type containing 12D Neighboring gene ETS variant transcription factor 5, pseudogene 1 Neighboring gene uncharacterized LOC108348767 Neighboring gene uronyl-2-sulfotransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Assigning pathogenicity for TAB2 variants using a novel scalable functional assay and expanding TAB2 disease spectrum. Xu W, et al. Hum Mol Genet, 2023 Mar 6. PMID 36229919, Free PMC Article
  2. In vivo therapeutic success of MicroRNA-155 antagomir in a mouse model of pulmonary fibrosis induced by bleomycin. Sun X, et al. Korean J Intern Med, 2021 Mar. PMID 32506869, Free PMC Article
  3. Protein molecular modeling techniques investigating novel TAB2 variant R347X causing cardiomyopathy and congenital heart defects in multigenerational family. Caulfield TR, et al. Mol Genet Genomic Med, 2018 Apr 26. PMID 29700987, Free PMC Article
  4. MiR-199a target regulates TAB2 to promote the migration of endodermal progenitor cells and inhibit deep vein thrombosis in rats. Ni X, et al. Minerva Pediatr (Torino), 2023 Feb. PMID 36322021
  5. Associations between TAB2 Gene Polymorphisms and Epithelial Ovarian Cancer in a Chinese Population. Huang X, et al. Dis Markers, 2019. PMID 31485280, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-199a target regulates TAB2 to promote the migration of endodermal progenitor cells and inhibit deep vein thrombosis in rats.
    Title: MiR-199a target regulates TAB2 to promote the migration of endodermal progenitor cells and inhibit deep vein thrombosis in rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in heart development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Names
TGF-beta-activated kinase 1-binding protein 2
mitogen-activated protein kinase kinase kinase 7-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393814.1 → NP_001380743.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q5U303
    UniProtKB/TrEMBL
    A6JP22
    Related
    ENSRNOP00000021904.3, ENSRNOT00000021905.8
    Conserved Domains (4) summary
    smart00547
    Location:667 → 690
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:9 → 50
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    sd00029
    Location:668 → 687
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam10473
    Location:541 → 619
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    4195400..4245485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288633.1 → XP_063144703.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q5U303
    UniProtKB/TrEMBL
    A6JP22

  2. XM_039110915.2 → XP_038966843.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    Conserved Domains (1) summary
    cd14362
    Location:9 → 50
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

  3. XM_039110917.2 → XP_038966845.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    Conserved Domains (1) summary
    cd14362
    Location:9 → 50
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

  4. XM_039110921.2 → XP_038966849.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    Conserved Domains (1) summary
    cd14362
    Location:9 → 50
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

  5. XM_039110919.2 → XP_038966847.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

    Conserved Domains (1) summary
    cd14362
    Location:9 → 50
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

  6. XM_063288630.1 → XP_063144700.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001012062.1: Suppressed sequence

    Description
    NM_001012062.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U303.2 GenPept UniProtKB/Swiss-Prot:Q5U303

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