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ST6GALNAC6 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 [ Homo sapiens (human) ]

Gene ID: 30815, updated on 11-Apr-2024

Summary

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Official Symbol
ST6GALNAC6provided by HGNC
Official Full Name
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6provided by HGNC
Primary source
HGNC:HGNC:23364
See related
Ensembl:ENSG00000160408 MIM:610135; AllianceGenome:HGNC:23364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIAT7F; SIAT7-F; ST6GALNACVI
Summary
ST6GALNAC6 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to alter cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 [PubMed 12668675]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in colon (RPKM 34.9), fat (RPKM 30.2) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See ST6GALNAC6 in Genome Data Viewer
Location:
9q34.11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (127885321..127906616, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (140093108..140114388, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130647600..130668895, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene endoglin Neighboring gene ST6GALNAC4-ST6GALNAC6-AK1 readthrough Neighboring gene uncharacterized LOC124902279 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130616269-130617185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130618546-130619046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130619047-130619547 Neighboring gene CRISPRi-validated cis-regulatory element chr9.2869 Neighboring gene Sharpr-MPRA regulatory region 4407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29056 Neighboring gene Sharpr-MPRA regulatory region 6524 Neighboring gene microRNA 4672 Neighboring gene adenylate kinase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130645163-130645663 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130646401-130647398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130658469-130659290 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20314 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130660112-130660932 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130660933-130661753 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20315 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29057 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130667147-130667673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130667812-130668411 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20317 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:130685680-130686879 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130688781-130689504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130689505-130690228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130690229-130690952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130691676-130692399 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20318 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers. Senda M, et al. Biochem J, 2007 Mar 15. PMID 17123352, Free PMC Article
  2. Molecular cloning and expression of mouse GD1alpha/GT1aalpha/GQ1balpha synthase (ST6GalNAc VI) gene. Okajima T, et al. J Biol Chem, 2000 Mar 10. PMID 10702226
  3. Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. Tsuchida A, et al. J Biol Chem, 2003 Jun 20. PMID 12668675
  4. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
  5. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. Virok DP, et al. J Proteome Res, 2011 Apr 1. PMID 21244100

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ST6GalNAc-VI and disialylgalactosylgloboside were found in proximal tubule epithelial cells in normal kidney tissues
    Title: Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers.
  2. novel substrate specificity of ST6GalNAc VI, which is responsible for the synthesis of disialyl Lea but not for alpha-series gangliosides in human colon tissues
    Title: Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough ST6GALNAC4-ST6GALNAC6-AK1

Readthrough gene: ST6GALNAC4-ST6GALNAC6-AK1, Included gene: AK1, Included gene: ST6GALNAC4

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell recognition IC
Inferred by Curator
more info
 PubMed 
involved_in ganglioside biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ganglioside biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycoprotein metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycosphingolipid biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in glycosphingolipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycosylceramide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oligosaccharide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in oligosaccharide biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Names
CMP-NeuAC:(beta)-N-acetylgalactosaminide (alpha)2,6-sialyltransferase member VI
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
ST6 -N-acetylgalactosaminide alpha-26-sialyltransferase 6
ST6 GalNAc alpha-2,6-sialyltransferase 6
epididymis secretory sperm binding protein
galNAc alpha-2,6-sialyltransferase VI
sialyltransferase 7F
sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialytransferase) F
NP_001273928.1
NP_001273929.1
NP_001273930.1
NP_001273931.1
NP_001273932.1
NP_001375418.1
NP_001387759.1
NP_001387760.1
NP_001387761.1
NP_001387762.1
NP_001387763.1
NP_001387764.1
NP_038471.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286999.2 → NP_001273928.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform b

    See identical proteins and their annotated locations for NP_001273928.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is longer than isoform a.
    Source sequence(s)
    AL157935
    Consensus CDS
    CCDS69669.1
    UniProtKB/Swiss-Prot
    Q969X2
    Related
    ENSP00000362235.1, ENST00000373142.5
    Conserved Domains (1) summary
    pfam00777
    Location:102 → 266
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. NM_001287000.2 → NP_001273929.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform c precursor

    See identical proteins and their annotated locations for NP_001273929.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' region, resulting in translation initiation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4, 5 and 10 all encode isoform c.
    Source sequence(s)
    AL157935
    Consensus CDS
    CCDS69668.1
    UniProtKB/TrEMBL
    A0A2R8YFX0
    Related
    ENSP00000362237.3, ENST00000373144.7
    Conserved Domains (1) summary
    pfam00777
    Location:68 → 253
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. NM_001287001.2 → NP_001273930.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform c precursor

    See identical proteins and their annotated locations for NP_001273930.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4, 5 and 10 all encode isoform c.
    Source sequence(s)
    AL157935
    Consensus CDS
    CCDS69668.1
    UniProtKB/TrEMBL
    A0A2R8YFX0
    Related
    ENSP00000362234.1, ENST00000373141.5
    Conserved Domains (1) summary
    pfam00777
    Location:68 → 253
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  4. NM_001287002.2 → NP_001273931.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform c precursor

    See identical proteins and their annotated locations for NP_001273931.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4, 5 and 10 all encode isoform c.
    Source sequence(s)
    AL157935
    Consensus CDS
    CCDS69668.1
    UniProtKB/TrEMBL
    A0A2R8YFX0
    Related
    ENSP00000477575.1, ENST00000622357.5
    Conserved Domains (1) summary
    pfam00777
    Location:68 → 253
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  5. NM_001287003.2 → NP_001273932.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform d precursor

    See identical proteins and their annotated locations for NP_001273932.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation from a downstream in-frame start codon, and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a. Variants 6 and 11 encode isoform d.
    Source sequence(s)
    AL157935
    Consensus CDS
    CCDS75908.1
    UniProtKB/TrEMBL
    F6SGE3
    Related
    ENSP00000438109.2, ENST00000542456.5

  6. NM_001388489.1 → NP_001375418.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AL157935
    Consensus CDS
    CCDS69668.1
    UniProtKB/TrEMBL
    A0A2R8YFX0
    Conserved Domains (1) summary
    pfam00777
    Location:68 → 253
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  7. NM_001400830.1 → NP_001387759.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL157935

  8. NM_001400831.1 → NP_001387760.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AL157935
    Consensus CDS
    CCDS69668.1

  9. NM_001400832.1 → NP_001387761.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform d precursor

    Status: VALIDATED

    Source sequence(s)
    AL157935
    Consensus CDS
    CCDS75908.1
    UniProtKB/TrEMBL
    F6SGE3

  10. NM_001400833.1 → NP_001387762.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform f precursor

    Status: VALIDATED

    Source sequence(s)
    AL157935

  11. NM_001400834.1 → NP_001387763.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform f precursor

    Status: VALIDATED

    Source sequence(s)
    AL157935

  12. NM_001400835.1 → NP_001387764.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform f precursor

    Status: VALIDATED

    Source sequence(s)
    AL157935

  13. NM_013443.5 → NP_038471.2  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform a

    See identical proteins and their annotated locations for NP_038471.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AL157935
    Consensus CDS
    CCDS6882.1
    UniProtKB/Swiss-Prot
    B3KQ01, Q5T9C4, Q5T9C5, Q969X2, Q9H8A2, Q9ULB8
    UniProtKB/TrEMBL
    A0A0S2Z5G9, A0A2R8YFX0
    Related
    ENSP00000362239.1, ENST00000373146.6
    Conserved Domains (1) summary
    pfam00777
    Location:96 → 287
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. NR_104629.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has alternate 5' exon structure and uses two alternate splice sites in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL157935

  2. NR_174612.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL157935

  3. NR_174613.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL157935

  4. NR_174614.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL157935

  5. NR_174615.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL157935
    Related
    ENST00000291839.10

  6. NR_174616.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL157935

  7. NR_174617.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL157935

  8. NR_174618.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL157935

  9. NR_174619.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL157935

  10. NR_174620.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL157935

  11. NR_174621.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL157935

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    127885321..127906616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    140093108..140114388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q969X2.1 GenPept UniProtKB/Swiss-Prot:Q969X2

Gene LinkOut

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