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Iyd iodotyrosine deiodinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 308129, updated on 10-Jul-2024

Summary

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Official Symbol
Iydprovided by RGD
Official Full Name
iodotyrosine deiodinaseprovided by RGD
Primary source
RGD:1309288
See related
EnsemblRapid:ENSRNOG00000016286 AllianceGenome:RGD:1309288
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309288
Summary
Predicted to enable FMN binding activity and iodotyrosine deiodinase activity. Predicted to be involved in thyroid hormone metabolic process and tyrosine metabolic process. Predicted to be located in cytoplasmic vesicle membrane; nucleoplasm; and plasma membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in thyroid dyshormonogenesis 4. Orthologous to human IYD (iodotyrosine deiodinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 551.5) and Kidney (RPKM 446.7) See more
Orthologs
human mouse all
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Genomic context

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See Iyd in Genome Data Viewer
Location:
1p11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (42410099..42425414)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (40003999..40019323)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (40086513..40100966)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555832 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14c Neighboring gene pleckstrin homology and RhoGEF domain containing G1 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene cytochrome c, somatic like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of Iodotyrosine Deiodinase in Thyroid and Other Organs in Iodine-Deficient and Iodine-Excess Rats. Sun X, et al. Biol Trace Elem Res, 2015 Oct. PMID 25850545
  2. A switch between one- and two-electron chemistry of the human flavoprotein iodotyrosine deiodinase is controlled by substrate. Hu J, et al. J Biol Chem, 2015 Jan 2. PMID 25395621, Free PMC Article
  3. Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site. Gnidehou S, et al. FASEB J, 2004 Oct. PMID 15289438
  4. Iodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin reductase superfamily. Friedman JE, et al. J Biol Chem, 2006 Feb 3. PMID 16316988
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. iodine deficiency results in an increased expression of IYD in thyroid, whereas excess iodine decreases the expression of thyroidal IYD.
    Title: Expression of Iodotyrosine Deiodinase in Thyroid and Other Organs in Iodine-Deficient and Iodine-Excess Rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC109018

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables FMN binding ISO
Inferred from Sequence Orthology
more info
  
enables FMN binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables iodotyrosine deiodinase activity ISO
Inferred from Sequence Orthology
more info
  
enables iodotyrosine deiodinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in thyroid hormone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thyroid hormone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in thyroid hormone metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tyrosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tyrosine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in tyrosine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
iodotyrosine deiodinase 1
Names
IYD-1
iodotyrosine dehalogenase 1
NP_001020171.1
XP_038966572.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025000.1 → NP_001020171.1  iodotyrosine deiodinase 1

    See identical proteins and their annotated locations for NP_001020171.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091241
    UniProtKB/Swiss-Prot
    Q5BK17
    UniProtKB/TrEMBL
    A6KIK2
    Related
    ENSRNOP00000021893.4, ENSRNOT00000021895.9
    Conserved Domains (1) summary
    cd02144
    Location:89 → 281
    iodotyrosine_dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    42410099..42425414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110644.2 → XP_038966572.1  iodotyrosine deiodinase 1 isoform X1

    Conserved Domains (1) summary
    cl00514
    Location:89 → 174
    Nitro_FMN_reductase; nitroreductase family protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BK17.1 GenPept UniProtKB/Swiss-Prot:Q5BK17

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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