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Nkd2 NKD inhibitor of WNT signaling pathway 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308068, updated on 17-Aug-2024

Summary

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Official Symbol
Nkd2provided by RGD
Official Full Name
NKD inhibitor of WNT signaling pathway 2provided by RGD
Primary source
RGD:1311459
See related
EnsemblRapid:ENSRNOG00000016103 AllianceGenome:RGD:1311459
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable enzyme binding activity; growth factor binding activity; and myosin heavy chain binding activity. Predicted to be involved in several processes, including Golgi vesicle fusion to target membrane; positive regulation of protein localization to plasma membrane; and positive regulation of proteolysis. Predicted to be located in basolateral plasma membrane; exocytic vesicle; and lateral plasma membrane. Predicted to be active in cytoplasm. Orthologous to human NKD2 (NKD inhibitor of WNT signaling pathway 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 46.3), Kidney (RPKM 28.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nkd2 in Genome Data Viewer
Location:
1p11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (31268856..31299390)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (29442898..29470839)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (32054390..32085416)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene bromodomain containing 9 Neighboring gene small nucleolar RNA SNORA21 Neighboring gene thyroid hormone receptor interactor 13 Neighboring gene solute carrier family 12 member 7 Neighboring gene solute carrier family 6 member 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Up-Regulation of Corticocerebral NKD2 in Lipopolysaccharide-Induced Neuroinflammation. Cui Z, et al. Cell Mol Neurobiol, 2016 Jan. PMID 26084600
  2. Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-alpha containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells. Li C, et al. Mol Biol Cell, 2007 Aug. PMID 17553928, Free PMC Article
  3. Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells. Li C, et al. Proc Natl Acad Sci U S A, 2004 Apr 13. PMID 15064403, Free PMC Article
  4. EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation. Ding W, et al. Proc Natl Acad Sci U S A, 2008 Sep 9. PMID 18757723, Free PMC Article
  5. PR72, a novel regulator of Wnt signaling required for Naked cuticle function. Creyghton MP, et al. Genes Dev, 2005 Feb 1. PMID 15687260, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypoxic Bone Mesenchymal Stem Cell-Derived Exosomes Direct Schwann Cells Proliferation, Migration, and Paracrine to Accelerate Facial Nerve Regeneration via circRNA_Nkd2/miR-214-3p/MED19 Axis.
    Title: Hypoxic Bone Mesenchymal Stem Cell-Derived Exosomes Direct Schwann Cells Proliferation, Migration, and Paracrine to Accelerate Facial Nerve Regeneration via circRNA_Nkd2/miR-214-3p/MED19 Axis.
  2. NKD2 might be involved in neuronal apoptosis via the Wnt/beta-catenin pathway during neuroinflammation.
    Title: Up-Regulation of Corticocerebral NKD2 in Lipopolysaccharide-Induced Neuroinflammation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables myosin heavy chain binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi vesicle fusion to target membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in exocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein naked cuticle homolog 2
Names
NKD2, WNT signaling pathway inhibitor
naked cuticle 2 homolog
naked cuticle homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107454.1 → NP_001100924.1  protein naked cuticle homolog 2

    See identical proteins and their annotated locations for NP_001100924.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474002
    UniProtKB/TrEMBL
    A6JUW2, D4A182
    Related
    ENSRNOP00000021898.5, ENSRNOT00000021898.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    31268856..31299390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288362.1 → XP_063144432.1  protein naked cuticle homolog 2 isoform X1

  2. XM_063288366.1 → XP_063144436.1  protein naked cuticle homolog 2 isoform X1

  3. XM_017589090.2 → XP_017444579.1  protein naked cuticle homolog 2 isoform X2

    UniProtKB/TrEMBL
    A6JUW2, D4A182

  4. XM_063288369.1 → XP_063144439.1  protein naked cuticle homolog 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A1L5

  5. XM_063288371.1 → XP_063144441.1  protein naked cuticle homolog 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A619
    Related
    ENSRNOP00000086365.1, ENSRNOT00000118428.2
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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