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Nrap nebulin-related anchoring protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 307982, updated on 4-Jan-2025

Summary

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Official Symbol
Nrapprovided by RGD
Official Full Name
nebulin-related anchoring proteinprovided by RGD
Primary source
RGD:1306731
See related
EnsemblRapid:ENSRNOG00000016714 AllianceGenome:RGD:1306731
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin filament binding activity; muscle alpha-actinin binding activity; and vinculin binding activity. Predicted to be involved in cardiac muscle thin filament assembly. Predicted to be located in fascia adherens; muscle tendon junction; and myofibril. Predicted to be active in Z disc. Orthologous to human NRAP (nebulin related anchoring protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 2415.4) and Heart (RPKM 812.4) See more
Orthologs
human mouse all
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Genomic context

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See Nrap in Genome Data Viewer
Location:
1q55
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (265355324..265433229, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (255350113..255427704, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (277104519..277181397, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100063 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene hyaluronan binding protein 2 Neighboring gene caspase 7 Neighboring gene pleckstrin homology domain containing S1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. N-RAP expression during mouse heart development. Lu S, et al. Dev Dyn, 2005 May. PMID 15765519
  2. Complete cDNA sequence and tissue localization of N-RAP, a novel nebulin-related protein of striated muscle. Luo G, et al. Cell Motil Cytoskeleton, 1997. PMID 9295142
  3. Molecular interactions of N-RAP, a nebulin-related protein of striated muscle myotendon junctions and intercalated disks. Luo G, et al. Biochemistry, 1999 May 11. PMID 10320340
  4. New N-RAP-binding partners alpha-actinin, filamin and Krp1 detected by yeast two-hybrid screening: implications for myofibril assembly. Lu S, et al. J Cell Sci, 2003 Jun 1. PMID 12692149
  5. Ultrastructural and biochemical localization of N-RAP at the interface between myofibrils and intercalated disks in the mouse heart. Zhang JQ, et al. Biochemistry, 2001 Dec 11. PMID 11732910

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables muscle alpha-actinin binding ISO
Inferred from Sequence Orthology
more info
  
enables vinculin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cardiac muscle thin filament assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fascia adherens ISO
Inferred from Sequence Orthology
more info
  
located_in muscle tendon junction ISO
Inferred from Sequence Orthology
more info
  
located_in myofibril ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nebulin-related-anchoring protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107443.2 → NP_001100913.2  nebulin-related-anchoring protein isoform C

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (C) has the same N- and C-termini but is shorter compared to isoform S.
    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6A7A7
    Related
    ENSRNOP00000106373.1, ENSRNOT00000149841.1
    Conserved Domains (3) summary
    smart00227
    Location:485 → 515
    NEBU; The Nebulin repeat is present also in Las1
    cd09446
    Location:6 → 58
    LIM_N_RAP; The LIM domain of N-RAP
    pfam00880
    Location:313 → 339
    Nebulin; Nebulin repeat

  2. NM_001113743.1 → NP_001107215.1  nebulin-related-anchoring protein isoform S

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (S).
    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6A7A7
    Related
    ENSRNOP00000086892.1, ENSRNOT00000115960.2
    Conserved Domains (3) summary
    smart00227
    Location:520 → 550
    NEBU; The Nebulin repeat is present also in Las1
    cd09446
    Location:6 → 58
    LIM_N_RAP; The LIM domain of N-RAP
    pfam00880
    Location:313 → 339
    Nebulin; Nebulin repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    265355324..265433229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110118.2 → XP_038966046.1  nebulin-related-anchoring protein isoform X4

    UniProtKB/TrEMBL
    A0A8I6A7A7
    Conserved Domains (3) summary
    smart00227
    Location:521 → 551
    NEBU; The Nebulin repeat is present also in Las1
    cd09446
    Location:6 → 58
    LIM_N_RAP; The LIM domain of N-RAP
    pfam00880
    Location:562 → 589
    Nebulin; Nebulin repeat

  2. XM_006231644.5 → XP_006231706.1  nebulin-related-anchoring protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6A7A7, D4A4K6
    Related
    ENSRNOP00000030387.5, ENSRNOT00000038038.8
    Conserved Domains (3) summary
    smart00227
    Location:521 → 551
    NEBU; The Nebulin repeat is present also in Las1
    cd09446
    Location:6 → 58
    LIM_N_RAP; The LIM domain of N-RAP
    pfam00880
    Location:314 → 340
    Nebulin; Nebulin repeat

  3. XM_008760535.4 → XP_008758757.1  nebulin-related-anchoring protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6A7A7, D3Z802
    Related
    ENSRNOP00000029499.4, ENSRNOT00000038017.5
    Conserved Domains (3) summary
    smart00227
    Location:486 → 516
    NEBU; The Nebulin repeat is present also in Las1
    cd09446
    Location:6 → 58
    LIM_N_RAP; The LIM domain of N-RAP
    pfam00880
    Location:314 → 340
    Nebulin; Nebulin repeat

  4. XM_039110113.2 → XP_038966041.1  nebulin-related-anchoring protein isoform X3

    UniProtKB/TrEMBL
    A0A8I6A7A7
    Related
    ENSRNOP00000106739.1, ENSRNOT00000128823.1
    Conserved Domains (3) summary
    smart00227
    Location:460 → 490
    NEBU; The Nebulin repeat is present also in Las1
    pfam00880
    Location:501 → 528
    Nebulin; Nebulin repeat
    cl02475
    Location:6 → 25
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein Strain
Heading Accession and Version

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