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Chst5 carbohydrate sulfotransferase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307859, updated on 2-Nov-2024

Summary

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Official Symbol
Chst5provided by RGD
Official Full Name
carbohydrate sulfotransferase 5provided by RGD
Primary source
RGD:1561144
See related
EnsemblRapid:ENSRNOG00000021521 AllianceGenome:RGD:1561144
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561144
Summary
Predicted to enable N-acetylglucosamine 6-O-sulfotransferase activity and keratan sulfotransferase activity. Predicted to be involved in N-acetylglucosamine metabolic process and keratan sulfate biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in trans-Golgi network. Human ortholog(s) of this gene implicated in macular corneal dystrophy. Orthologous to several human genes including CHST6 (carbohydrate sulfotransferase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Uterus (RPKM 9.4), Brain (RPKM 9.0) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Chst5 in Genome Data Viewer
Location:
19q12
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (56769991..56790276, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (39860729..39881019, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (44115065..44136092, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 170A Neighboring gene U6 spliceosomal RNA Neighboring gene transmembrane protein 231 Neighboring gene GABA type A receptor associated protein like 2 Neighboring gene adenosine deaminase, tRNA-specific 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta). Bartes A, et al. Biochem Biophys Res Commun, 2001 Apr 13. PMID 11352640
  2. Human corneal GlcNac 6-O-sulfotransferase and mouse intestinal GlcNac 6-O-sulfotransferase both produce keratan sulfate. Akama TO, et al. J Biol Chem, 2001 May 11. PMID 11278593
  3. Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate. Akama TO, et al. J Biol Chem, 2002 Nov 8. PMID 12218059
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetylglucosamine 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylglucosamine 6-O-sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables keratan sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in N-acetylglucosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-acetylglucosamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in keratan sulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratan sulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfur compound metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carbohydrate sulfotransferase 5
Names
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
NP_001100901.1
XP_006255694.1
XP_006255695.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107431.1 → NP_001100901.1  carbohydrate sulfotransferase 5

    See identical proteins and their annotated locations for NP_001100901.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473972
    UniProtKB/TrEMBL
    A6IZB3, D4A9P8
    Related
    ENSRNOP00000026262.2, ENSRNOT00000026262.7
    Conserved Domains (1) summary
    cl21551
    Location:190 → 380
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    56769991..56790276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255633.5 → XP_006255695.1  carbohydrate sulfotransferase 5 isoform X1

    See identical proteins and their annotated locations for XP_006255695.1

    UniProtKB/TrEMBL
    A0A8I6GGK1, A6IZB4
    Related
    ENSRNOP00000088767.1, ENSRNOT00000109790.2
    Conserved Domains (1) summary
    pfam13469
    Location:43 → 297
    Sulfotransfer_3; Sulfotransferase family

  2. XM_006255632.5 → XP_006255694.1  carbohydrate sulfotransferase 5 isoform X1

    See identical proteins and their annotated locations for XP_006255694.1

    UniProtKB/TrEMBL
    A0A8I6GGK1, A6IZB4
    Conserved Domains (1) summary
    pfam13469
    Location:43 → 297
    Sulfotransfer_3; Sulfotransferase family
Nucleotide Protein Strain
Heading Accession and Version

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