U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

UL122 regulatory protein IE2 [ Human betaherpesvirus 5 ]

Gene ID: 3077563, updated on 18-Aug-2023

Summary

Go to the top of the page Help
Gene symbol
UL122
Gene description
regulatory protein IE2
Locus tag
HHV5wtgp107
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human betaherpesvirus 5 (strain: Merlin, acronym: HHV-5; HCMV, nat-host: Homo sapiens, culture-collection: ATCC:VR-1590)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_006273.2 (170689..174090, complement)

NC_006273.2Genomic Context describing neighboring genes Neighboring gene membrane protein UL120 Neighboring gene membrane protein UL121 Neighboring gene membrane protein UL124 Neighboring gene regulatory protein IE1 Neighboring gene envelope glycoprotein UL130 Neighboring gene envelope protein UL131A

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_006273.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The role of autophagy in human cytomegalovirus IE2 expression. Zhang X, et al. J Med Virol, 2021 Jun. PMID 32710640
  2. Importance of covalent and noncovalent SUMO interactions with the major human cytomegalovirus transactivator IE2p86 for viral infection. Berndt A, et al. J Virol, 2009 Dec. PMID 19812159, Free PMC Article
  3. Human cytomegalovirus IE2 86-kilodalton protein binds p53 but does not abrogate G1 checkpoint function. Bonin LR, et al. J Virol, 1997 Aug. PMID 9223475, Free PMC Article
  4. Characteristics of Immediate-Early 2 (IE2) and UL84 Proteins in UL84-Independent Strains of Human Cytomegalovirus (HCMV). Manska S, et al. Microbiol Spectr, 2021 Oct 31. PMID 34550009, Free PMC Article
  5. Identification of domains within the human cytomegalovirus major immediate-early 86-kilodalton protein and the retinoblastoma protein required for physical and functional interaction with each other. Fortunato EA, et al. J Virol, 1997 Nov. PMID 9343168, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characteristics of Immediate-Early 2 (IE2) and UL84 Proteins in UL84-Independent Strains of Human Cytomegalovirus (HCMV).
    Title: Characteristics of Immediate-Early 2 (IE2) and UL84 Proteins in UL84-Independent Strains of Human Cytomegalovirus (HCMV).
  2. The role of autophagy in human cytomegalovirus IE2 expression.
    Title: The role of autophagy in human cytomegalovirus IE2 expression.
  3. Human cytomegalovirus DNA and immediate early protein 1/2 are highly associated with glioma and prognosis.
    Title: Human cytomegalovirus DNA and immediate early protein 1/2 are highly associated with glioma and prognosis.
  4. Cytotoxic lymphocytes induce the degradation of viral immediate-early (IE) proteins IE1 and IE2 in HCMV-infected cells.
    Title: Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner.
  5. Our data suggested that HCMV. ie2 promotes glioblastoma migration by regulating hnRNP A2B1 expression
    Title: Human cytomegalovirus ie2 affects the migration of glioblastoma by mediating the different splicing patterns of RON through hnRNP A2B1.
  6. Protein-protein interaction analyses demonstrated that pUL34 interacts with the viral proteins IE2, UL44, and UL84, that are essential for viral DNA replication.
    Title: pUL34 binding near the human cytomegalovirus origin of lytic replication enhances DNA replication and viral growth.
  7. Human cytomegalovirus downregulates SLITRK6 expression through IE2.
    Title: Human cytomegalovirus downregulates SLITRK6 expression through IE2.
  8. data reveal that MICA and PVR are directly regulated by human cytomegalovirus immediate early proteins, and this may be crucial for the onset of an early host antiviral response
    Title: Distinct Roles for Human Cytomegalovirus Immediate Early Proteins IE1 and IE2 in the Transcriptional Regulation of MICA and PVR/CD155 Expression.
  9. This study connects human cytomegalovirus IE2 to myocardin-induced transcriptional program for rat aortic smooth muscle cells survival and proliferation.
    Title: Human cytomegalovirus immediate early protein 2 enhances myocardin-mediated survival of rat aortic smooth muscle cells.
  10. Codon 388 of the UL122 gene is essential for virus replication.
    Title: UL84-independent replication of human cytomegalovirus strains conferred by a single codon change in UL122.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

  • beta gene; immediate early gene

General protein information

Go to the top of the page Help
Preferred Names
regulatory protein IE2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006273.2 Reference assembly

    Range
    170689..174090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_081561.1 regulatory protein IE2 [Human betaherpesvirus 5]

    See identical proteins and their annotated locations for YP_081561.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    D2K3S1, Q6SW29
    UniProtKB/TrEMBL
    A0A1D6WSE1, D2IG93, F5HE22
    Conserved Domains (2) summary
    pfam03361
    Location:383 → 543
    Herpes_IE2_3; Herpes virus intermediate/early protein 2/3
    pfam07340
    Location:1 → 85
    Herpes_IE1; Cytomegalovirus IE1 protein
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.