U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

UL82 tegument protein pp71 [ Human betaherpesvirus 5 ]

Gene ID: 3077530, updated on 18-Aug-2023

Summary

Go to the top of the page Help
Gene symbol
UL82
Gene description
tegument protein pp71
Locus tag
HHV5wtgp076
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human betaherpesvirus 5 (strain: Merlin, acronym: HHV-5; HCMV, nat-host: Homo sapiens, culture-collection: ATCC:VR-1590)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_006273.2 (118788..120467, complement)

NC_006273.2Genomic Context describing neighboring genes Neighboring gene protein UL79 Neighboring gene capsid maturation protease Neighboring gene capsid scaffold protein Neighboring gene tegument protein pp65 Neighboring gene protein UL84

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_006273.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Protein S-Nitrosylation of Human Cytomegalovirus pp71 Inhibits Its Ability To Limit STING Antiviral Responses. Nukui M, et al. J Virol, 2020 Aug 17. PMID 32581105, Free PMC Article
  2. Nuclear localization of tegument-delivered pp71 in human cytomegalovirus-infected cells is facilitated by one or more factors present in terminally differentiated fibroblasts. Penkert RR, et al. J Virol, 2010 Oct. PMID 20686028, Free PMC Article
  3. Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity. Fu YZ, et al. Cell Host Microbe, 2017 Feb 8. PMID 28132838
  4. Stimulatory effects of human cytomegalovirus tegument protein pp71 lead to increased expression of CCL2 (monocyte chemotactic protein-1) during infection. Naing Z, et al. J Gen Virol, 2015 Jul. PMID 25711967
  5. Immediate-Early (IE) gene regulation of cytomegalovirus: IE1- and pp71-mediated viral strategies against cellular defenses. Torres L, et al. Virol Sin, 2014 Dec. PMID 25501994, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein S-Nitrosylation of Human Cytomegalovirus pp71 Inhibits Its Ability To Limit STING Antiviral Responses.
    Title: Protein S-Nitrosylation of Human Cytomegalovirus pp71 Inhibits Its Ability To Limit STING Antiviral Responses.
  2. Human Cytomegalovirus tegument protein UL82 negatively regulates STING-mediated signaling.
    Title: Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity.
  3. The data showed that human cytomegalovirus-induced upregulation of CCL2 during early stages of infection was mediated, at least in part, by stimulation of viral pp71, which may contribute to viral pathogenesis through enhanced virus dissemination.
    Title: Stimulatory effects of human cytomegalovirus tegument protein pp71 lead to increased expression of CCL2 (monocyte chemotactic protein-1) during infection.
  4. IE1- and pp71 mediated viral strategies against cellular defenses.[review]
    Title: Immediate-Early (IE) gene regulation of cytomegalovirus: IE1- and pp71-mediated viral strategies against cellular defenses.
  5. ICP0 of herpes simplex virus 1 augments replication of pp71 mutant human cytomegalovirus.
    Title: Analysis of the functional interchange between the IE1 and pp71 proteins of human cytomegalovirus and ICP0 of herpes simplex virus 1.
  6. pp71 stimulates major histocompatibility complex class i presentation of IE1-derived peptides at immediate early times of infection.
    Title: Human cytomegalovirus pp71 stimulates major histocompatibility complex class i presentation of IE1-derived peptides at immediate early times of infection.
  7. Authors show that only the proteasome 19S regulatory particle that normally participates in ubiquitin-dependent protein degradation, is required for human herpesvirus 5 pp71-mediated degradation of Rb and Daxx.
    Title: Ubiquitin-independent proteasomal degradation of tumor suppressors by human cytomegalovirus pp71 requires the 19S regulatory particle.
  8. These results suggest that the effects of cytomegalovirus IE1 and pp71 on subsets of ND10 components combine to mirror the overall activities of herpes simplex virus 1 ICP0.
    Title: The replication defect of ICP0-null mutant herpes simplex virus 1 can be largely complemented by the combined activities of human cytomegalovirus proteins IE1 and pp71.
  9. Heterogenous cell fusion experiments demonstrated that tegument-delivered pp71 found in the cytoplasm of undifferentiated NT2 cells could be driven into the nucleus by one or more factors provided by fully differentiated fibroblasts.
    Title: Nuclear localization of tegument-delivered pp71 in human cytomegalovirus-infected cells is facilitated by one or more factors present in terminally differentiated fibroblasts.
  10. ATRX, in addition to hDaxx, is a component of cellular intrinsic defenses that limit HCMV IE transcription and that displacement of ATRX from ND10 by pp71 is important for the efficient initiation of viral gene expression
    Title: Human cytomegalovirus protein pp71 displaces the chromatin-associated factor ATRX from nuclear domain 10 at early stages of infection.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

  • beta gene

General protein information

Go to the top of the page Help
Preferred Names
tegument protein pp71
YP_081530.1
  • DURP family

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006273.2 Reference assembly

    Range
    118788..120467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_081530.1 tegument protein pp71 [Human betaherpesvirus 5]

    See identical proteins and their annotated locations for YP_081530.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    F5HBC6
    UniProtKB/TrEMBL
    A0A076JX64, A0A140D1S9, C8BL26, Q6SW60, V9LLY2
    Conserved Domains (1) summary
    pfam05784
    Location:29 → 371
    Herpes_UL82_83; Betaherpesvirus UL82/83 protein N-terminus
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.