UL37 envelope glycoprotein UL37 [Human betaherpesvirus 5] - Gene

Summary

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Gene symbol: UL37
Gene description: envelope glycoprotein UL37
Locus tag: HHV5wtgp042
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Human betaherpesvirus 5 (strain: Merlin, acronym: HHV-5; HCMV, nat-host: Homo sapiens, culture-collection: ATCC:VR-1590)
Lineage: Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus
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Genomic context

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Sequence:: NC_006273.2 (50262..53060, complement)

NC_006273.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_006273.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Human cytomegalovirus infection with wild-type envelope glycoprotein UL37 (pUL37x1) has levels of metabolites similar to those infected with a mutant virus lacking the UL37x1 gene, subUL37x1. subUL37x1-infected cells have reduced levels of host proteins fatty acid elongase 7 and the endoplasmic reticulum stress-related kinase PERK. The levels of phospholipids-VLCFAs are lower in subUL37x1-infected cells.
Title: Human Cytomegalovirus pUL37x1 Is Important for Remodeling of Host Lipid Metabolism.
Authors establish that the UL37 exon 1 protein retargets Bax to the mitochondrion-associated membranes as well as to the outer mitochondrial membrane from immediate early through late times of infection.
Title: Human cytomegalovirus inhibits apoptosis by proteasome-mediated degradation of Bax at endoplasmic reticulum-mitochondrion contacts.
pUL37x1 promotes viral replication by efficient utilization of new mitochondria.
Title: Human cytomegalovirus infection increases mitochondrial biogenesis.
study shows human cytomegalovirus (HCMV)-induced viperin disrupts cellular metabolism to enhance infectious process; viperin interaction with vMIA (UL37) resulted in viperin relocalization from endoplasmic reticulum to mitochondria
Title: Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity.
The UL37 exon 1 associates with internal lipid rafts.
Title: The human cytomegalovirus protein UL37 exon 1 associates with internal lipid rafts.
These studies show a herpesvirus protein, human herpesvirus 5 pUL37x1, trafficking into the mitochondrion-associated membranes (MAM) during permissive infection and the virus-induced alteration of the MAM protein composition.
Title: Trafficking of UL37 proteins into mitochondrion-associated membranes during permissive human cytomegalovirus infection.
These results suggest that pUL37x1 sequential endoplasmic reticulum to mitochondrial trafficking requires a weakly hydrophobic leader and is regulated by mitochondrial targeting signal beta sequences.
Title: Intracellular sorting signals for sequential trafficking of human cytomegalovirus UL37 proteins to the endoplasmic reticulum and mitochondria.
immediate early gene UL37 encodes a novel MHC-like protein
Title: Cytomegalovirus immediate early gene UL37 encodes a novel MHC-like protein.

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Pathways from PubChem

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General gene information

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Homology

Orthologs from OrthoDB

beta gene; immediate early gene

General protein information

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Preferred Names: envelope glycoprotein UL37

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_006273.2 Reference assembly

Range

50262..53060 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

YP_081496.1 envelope glycoprotein UL37 [Human betaherpesvirus 5]

See identical proteins and their annotated locations for YP_081496.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

D2K3K5, Q6SW94

UniProtKB/TrEMBL

A0A0G2UBW4, A0A1D6WSZ0, C8CPD8, F5HI84

Conserved Domains (1) summary

PHA03171
Location:1 → 488

PHA03171; UL37 tegument protein; Provisional