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Ciapin1 cytokine induced apoptosis inhibitor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307649, updated on 10-Jul-2024

Summary

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Official Symbol
Ciapin1provided by RGD
Official Full Name
cytokine induced apoptosis inhibitor 1provided by RGD
Primary source
RGD:1549737
See related
EnsemblRapid:ENSRNOG00000016234 AllianceGenome:RGD:1549737
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 2 iron, 2 sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly. Predicted to act upstream of or within hemopoiesis and negative regulation of apoptotic process. Predicted to be located in mitochondrion; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human CIAPIN1 (cytokine induced apoptosis inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 112.2), Heart (RPKM 108.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ciapin1 in Genome Data Viewer
Location:
19p13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (10185955..10199120)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (10179963..10195511)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10596923..10612414)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene docking protein 4 Neighboring gene RNA polymerase II subunit C Neighboring gene coenzyme Q9 Neighboring gene C-C motif chemokine ligand 17 Neighboring gene aldo-keto reductase family 1 member B1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inhibition of miR-322-5p Protects Cardiac Myoblast Cells Against Hypoxia-Induced Apoptosis and Injury Through Regulating CIAPIN1. Cai X, et al. J Cardiovasc Pharmacol, 2021 Feb 1. PMID 33538533
  2. Downregulation of miR‑16 protects H9c2(2‑1) cells against hypoxia/reoxygenation damage by targeting CIAPIN1 and regulating the NF‑κB pathway. Zhang HJ, et al. Mol Med Rep, 2019 Oct. PMID 31432171, Free PMC Article
  3. Inhibition of miR-182-5p protects cardiomyocytes from hypoxia-induced apoptosis by targeting CIAPIN1. Zhang Y, et al. Biochem Cell Biol, 2018 Oct. PMID 29671338
  4. Subcellular localization of CIAPIN1. Hao Z, et al. J Histochem Cytochem, 2006 Dec. PMID 16957168, Free PMC Article
  5. Identification of a cytokine-induced antiapoptotic molecule anamorsin essential for definitive hematopoiesis. Shibayama H, et al. J Exp Med, 2004 Feb 16. PMID 14970183, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of miR-322-5p Protects Cardiac Myoblast Cells Against Hypoxia-Induced Apoptosis and Injury Through Regulating CIAPIN1.
    Title: Inhibition of miR-322-5p Protects Cardiac Myoblast Cells Against Hypoxia-Induced Apoptosis and Injury Through Regulating CIAPIN1.
  2. The present study illustrates that downregulation of miR16 may protect against H/Rinduced injury partially by targeting CIAPIN1 and the NFkappaB signaling pathway.
    Title: Downregulation of miR‑16 protects H9c2(2‑1) cells against hypoxia/reoxygenation damage by targeting CIAPIN1 and regulating the NF‑κB pathway.
  3. the knockdown of CIAPIN1 with small interfering RNAs (siRNAs) efficiently abolished the protective effects of miR-182-5p inhibitor on HICA, demonstrating that miR-182-5p plays a pro-apoptotic role in cardiomyocytes under hypoxic conditions by downregulating CIAPIN1.
    Title: Inhibition of miR-182-5p protects cardiomyocytes from hypoxia-induced apoptosis by targeting CIAPIN1.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC94686

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 2 iron, 2 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables 2 iron, 2 sulfur cluster binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
involved_in iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
anamorsin
Names
fe-S cluster assembly protein DRE2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007689.1 → NP_001007690.1  anamorsin

    See identical proteins and their annotated locations for NP_001007690.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083753
    UniProtKB/Swiss-Prot
    Q5XID1
    UniProtKB/TrEMBL
    A0A8I6ASY3, A6JY45
    Related
    ENSRNOP00000021769.3, ENSRNOT00000021769.7
    Conserved Domains (2) summary
    cd02440
    Location:21 → 96
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    pfam05093
    Location:233 → 301
    CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    10185955..10199120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255107.5 → XP_006255169.1  anamorsin isoform X1

    See identical proteins and their annotated locations for XP_006255169.1

    UniProtKB/Swiss-Prot
    Q5XID1
    UniProtKB/TrEMBL
    A0A8I6ASY3, A6JY45
    Conserved Domains (2) summary
    cd02440
    Location:21 → 96
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    pfam05093
    Location:233 → 301
    CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis

  2. XM_006255108.5 → XP_006255170.1  anamorsin isoform X1

    See identical proteins and their annotated locations for XP_006255170.1

    UniProtKB/Swiss-Prot
    Q5XID1
    UniProtKB/TrEMBL
    A0A8I6ASY3, A6JY45
    Related
    ENSRNOP00000106580.1, ENSRNOT00000172702.1
    Conserved Domains (2) summary
    cd02440
    Location:21 → 96
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    pfam05093
    Location:233 → 301
    CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis

  3. XM_006255106.5 → XP_006255168.1  anamorsin isoform X1

    See identical proteins and their annotated locations for XP_006255168.1

    UniProtKB/Swiss-Prot
    Q5XID1
    UniProtKB/TrEMBL
    A0A8I6ASY3, A6JY45
    Conserved Domains (2) summary
    cd02440
    Location:21 → 96
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    pfam05093
    Location:233 → 301
    CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis

  4. XM_063277990.1 → XP_063134060.1  anamorsin isoform X1

    UniProtKB/Swiss-Prot
    Q5XID1
    UniProtKB/TrEMBL
    A0A8I6ASY3, A6JY45
    Related
    ENSRNOP00000096214.1, ENSRNOT00000116645.2

  5. XM_039097710.2 → XP_038953638.1  anamorsin isoform X1

    UniProtKB/Swiss-Prot
    Q5XID1
    UniProtKB/TrEMBL
    A0A8I6ASY3, A6JY45
    Conserved Domains (2) summary
    cd02440
    Location:21 → 96
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    pfam05093
    Location:233 → 301
    CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XID1.1 GenPept UniProtKB/Swiss-Prot:Q5XID1

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