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mhc2dab major histocompatibility complex class II DAB gene [ Danio rerio (zebrafish) ]

Gene ID: 30762, updated on 2-Nov-2024

Summary

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Official Symbol
mhc2dabprovided by ZNC
Official Full Name
major histocompatibility complex class II DAB geneprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-200
See related
Ensembl:ENSDARG00000079105 AllianceGenome:ZFIN:ZDB-GENE-980526-200
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
DAB; DAB1; dab101; dab201; dab301; dab401; dab402; dab1*01; dab2*01; dab3*01; dab4*01; dab4*02; mhc2deb; mhciidab; zgc:110349; zgc:123077; zgc:152682; zgc:158870; mhc2d8.37b3; si:dkeyp-2h4.1
Summary
Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; and positive regulation of T cell activation. Predicted to act upstream of or within antigen processing and presentation and immune response. Predicted to be located in membrane. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Is expressed in heart. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to several human genes including HLA-DOB (major histocompatibility complex, class II, DO beta); HLA-DPB1 (major histocompatibility complex, class II, DP beta 1); and HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See mhc2dab in Genome Data Viewer
Location:
chromosome: 8
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (36466771..36469124, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (36434989..36436660, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene major histocompatibility complex class II d8.37b2 Neighboring gene si:busm1-194e12.8 Neighboring gene major histocompatibility complex class II DAA gene Neighboring gene solute carrier family 7 member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of major histocompatibility class IIβ genes in an endangered North American cyprinid fish, the Rio Grande silvery minnow (Hybognathus amarus). Osborne MJ, et al. Fish Shellfish Immunol, 2011 Jun. PMID 21463692
  2. Influence of kinship and MHC class II genotype on visual traits in zebrafish larvae (Danio rerio). Hinz C, et al. PLoS One, 2012. PMID 23251449, Free PMC Article
  3. Olfactory imprinting is triggered by MHC peptide ligands. Hinz C, et al. Sci Rep, 2013 Sep 30. PMID 24077566, Free PMC Article
  4. Trans-species polymorphism of class II Mhc loci in danio fishes. Graser R, et al. Immunogenetics, 1996. PMID 8613141
  5. Evidence that the separation of Mhc class II from class I loci in the zebrafish, Danio rerio, occurred by translocation. Kuroda N, et al. Immunogenetics, 2002 Sep. PMID 12242592

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC110349, MGC123077, MGC152682, MGC158870, MGC191506

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables MHC class II protein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within antigen processing and presentation IEA
Inferred from Electronic Annotation
more info
  
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in peptide antigen assembly with MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MHC class II protein complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
major histocompatibility complex class II DAB
Names
Brre-DAB1*04
MHC Brre-DAB4
MHC Brre-DEB
MHC class II antigen
major histocompatibility complex class II DA-beta-101
major histocompatibility complex class II DA-beta-201
major histocompatibility complex class II DA-beta-301
major histocompatibility complex class II DA-beta-401
major histocompatibility complex class II DA-beta-402
major histocompatibility complex class II DEB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131476.3 → NP_571551.3  major histocompatibility complex class II DAB precursor

    Status: VALIDATED

    Source sequence(s)
    CU694380
    UniProtKB/TrEMBL
    Q1MTC8, Q8MGW8
    Related
    ENSDARP00000100252.3, ENSDART00000111240.5
    Conserved Domains (2) summary
    pfam00969
    Location:29 → 104
    MHC_II_beta; Class II histocompatibility antigen, beta domain
    pfam07654
    Location:114 → 197
    C1-set; Immunoglobulin C1-set domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    36466771..36469124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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