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Arhgap26 Rho GTPase activating protein 26 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307459, updated on 10-Oct-2024

Summary

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Official Symbol
Arhgap26provided by RGD
Official Full Name
Rho GTPase activating protein 26provided by RGD
Primary source
RGD:1310923
See related
EnsemblRapid:ENSRNOG00000013920 AllianceGenome:RGD:1310923
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activator activity and phospholipid binding activity. Predicted to be involved in several processes, including actin cytoskeleton organization; regulation of small GTPase mediated signal transduction; and signal transduction. Predicted to be located in cytoskeleton and focal adhesion. Human ortholog(s) of this gene implicated in juvenile myelomonocytic leukemia. Orthologous to human ARHGAP26 (Rho GTPase activating protein 26). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 99.0), Heart (RPKM 96.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arhgap26 in Genome Data Viewer
Location:
18p11
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (30702602..31489047)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (30835806..31237945)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (31807052..32557176, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098127 Neighboring gene uncharacterized LOC134482935 Neighboring gene sprouty RTK signaling antagonist 4 Neighboring gene small ribosomal subunit protein uS5-like Neighboring gene uncharacterized LOC120098315 Neighboring gene fibroblast growth factor 1 Neighboring gene Cytochrome c oxidase subunit 7C, pseudogene 2 Neighboring gene uncharacterized LOC134482937 Neighboring gene uncharacterized LOC120098335 Neighboring gene uncharacterized LOC134482936 Neighboring gene uncharacterized LOC100911367 Neighboring gene nuclear receptor subfamily 3, group C, member 1 Neighboring gene poly(A) binding protein, cytoplasmic 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q. Borkhardt A, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10908648, Free PMC Article
  2. A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family. Eberth A, et al. Biochem J, 2009 Jan 1. PMID 18954304
  3. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mitophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395140.1 → NP_001382069.1  rho GTPase-activating protein 26

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I6AL79
    Related
    ENSRNOP00000094639.1, ENSRNOT00000106545.2
    Conserved Domains (4) summary
    cd07636
    Location:19 → 225
    BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
    cd12064
    Location:704 → 759
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:364 → 563
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:267 → 371
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    30702602..31489047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277362.1 → XP_063133432.1  rho GTPase-activating protein 26 isoform X2

  2. XM_006254660.5 → XP_006254722.1  rho GTPase-activating protein 26 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AL79, A0A8I6APL5
    Related
    ENSRNOP00000096429.1, ENSRNOT00000101992.2
    Conserved Domains (5) summary
    cd07636
    Location:19 → 225
    BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
    cd12064
    Location:759 → 814
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:364 → 563
    RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
    cd01249
    Location:267 → 371
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    pfam00169
    Location:267 → 364
    PH; PH domain

  3. XM_006254663.4 → XP_006254725.1  rho GTPase-activating protein 26 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZLR1, A0A8I6AAB3
    Related
    ENSRNOP00000090557.1, ENSRNOT00000115900.2
    Conserved Domains (5) summary
    cd07636
    Location:19 → 225
    BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
    cd12064
    Location:667 → 722
    SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase
    cd04374
    Location:364 → 563
    RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
    cd01249
    Location:267 → 371
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    pfam00169
    Location:267 → 364
    PH; PH domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107389.1: Suppressed sequence

    Description
    NM_001107389.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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