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cbfb core-binding factor subunit beta [ Danio rerio (zebrafish) ]

Gene ID: 30744, updated on 12-Sep-2024

Summary

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Official Symbol
cbfbprovided by ZNC
Official Full Name
core-binding factor subunit betaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-440
See related
Ensembl:ENSDARG00000040917 AllianceGenome:ZFIN:ZDB-GENE-980526-440
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
unp1266
Summary
Enables protein heterodimerization activity. Contributes to DNA binding activity and transcription coregulator activity. Acts upstream of or within several processes, including heart contraction; lymphoid lineage cell migration into thymus; and myofibril assembly. Located in Z disc and nucleus. Part of core-binding activity factor complex. Is expressed in several structures, including digestive system; ganglia; hematopoietic system; immune system; and pericardial region. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human CBFB (core-binding factor subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See cbfb in Genome Data Viewer
Location:
chromosome: 18
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (22994055..23072664)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (23004885..23082244)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene heat shock transcription factor 4 Neighboring gene guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a Neighboring gene uncharacterized LOC108179979 Neighboring gene uncharacterized LOC137488280 Neighboring gene uncharacterized LOC103909137 Neighboring gene myocyte enhancer factor 2aa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular characterization of cbfβ gene and identification of new transcription variants: implications for function. Simões B, et al. Arch Biochem Biophys, 2015 Feb 1. PMID 25575784
  2. JunB-CBFbeta signaling is essential to maintain sarcomeric Z-disc structure and when defective leads to heart failure. Meder B, et al. J Cell Sci, 2010 Aug 1. PMID 20605922
  3. Cbfβ2 controls differentiation of and confers homing capacity to prethymic progenitors. Tenno M, et al. J Exp Med, 2018 Feb 5. PMID 29343500, Free PMC Article
  4. Transcriptional regulation of gilthead seabream bone morphogenetic protein (BMP) 2 gene by bone- and cartilage-related transcription factors. Marques CL, et al. Gene, 2016 Jan 15. PMID 26456102
  5. Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis. Blake T, et al. Blood, 2000 Dec 15. PMID 11110689

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. As in mice, an alternative splicing event in zebrafish generates a Cbfbeta2-specific mRNA, important for ccr9 expression. Thus, despite phylogenetically and ontogenetically variable sites of origin of T cell progenitors, their robust thymus-homing capacity is ensured by an evolutionarily conserved mechanism.
    Title: Cbfβ2 controls differentiation of and confers homing capacity to prethymic progenitors.
  2. In neuronal fate determination, Runx co-factor Cbfbeta is essential for its function, but the high level of Runx3 expression can overcome the loss of Cbfbeta, demonstrating that Cbfbeta in this context serves solely as a signal amplifier of Runx3 activity.
    Title: An ancient neurotrophin receptor code; a single Runx/Cbfβ complex determines somatosensory neuron fate specification in zebrafish.
  3. characterization of cbfbeta gene
    Title: Molecular characterization of cbfβ gene and identification of new transcription variants: implications for function.
  4. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development
    Title: CBFβ and RUNX1 are required at 2 different steps during the development of hematopoietic stem cells in zebrafish.
  5. Data demonstrate for the first time an essential role of JunB-CBFbeta signaling for maintaining sarcomere architecture and function.
    Title: JunB-CBFbeta signaling is essential to maintain sarcomeric Z-disc structure and when defective leads to heart failure.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
contributes_to DNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to transcription coregulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lymphoid lineage cell migration into thymus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sarcomerogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
part_of core-binding factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of core-binding factor complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
core-binding factor subunit beta
Names
CCAAT-binding transcription factor subunit B
core-binding factor, beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199209.1 → NP_954679.1  core-binding factor subunit beta

    See identical proteins and their annotated locations for NP_954679.1

    Status: PROVISIONAL

    Source sequence(s)
    AF278758
    UniProtKB/TrEMBL
    A0A0B4P516, A0A0R4IV13, Q98U16
    Related
    ENSDARP00000138911.2, ENSDART00000171871.3
    Conserved Domains (1) summary
    pfam02312
    Location:1 → 162
    CBF_beta; Core binding factor beta subunit

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    22994055..23072664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159048.5 → XP_005159105.1  core-binding factor subunit beta isoform X3

    See identical proteins and their annotated locations for XP_005159105.1

    UniProtKB/TrEMBL
    A0A0B4P4A4, A0A0B4PIF9, A0A140LGH3
    Related
    ENSDARP00000059960.2, ENSDART00000059961.3
    Conserved Domains (1) summary
    pfam02312
    Location:1 → 162
    CBF_beta; Core binding factor beta subunit

  2. XM_021467588.2 → XP_021323263.1  core-binding factor subunit beta isoform X3

    UniProtKB/TrEMBL
    A0A0B4P4A4, A0A0B4PIF9, A0A140LGH3
    Related
    ENSDARP00000142352.1, ENSDART00000173201.2
    Conserved Domains (1) summary
    pfam02312
    Location:1 → 162
    CBF_beta; Core binding factor beta subunit

  3. XM_009293530.4 → XP_009291805.1  core-binding factor subunit beta isoform X1

    UniProtKB/TrEMBL
    A0A140LGT1, A0A8M3ARW3
    Related
    ENSDARP00000142460.1, ENSDART00000172923.2
    Conserved Domains (1) summary
    pfam02312
    Location:1 → 162
    CBF_beta; Core binding factor beta subunit

  4. XM_009293532.4 → XP_009291807.1  core-binding factor subunit beta isoform X4

    See identical proteins and their annotated locations for XP_009291807.1

    UniProtKB/TrEMBL
    A0A0B4PIS7, A0A8M3AJI5
    Related
    ENSDARP00000142411.1, ENSDART00000141521.3
    Conserved Domains (1) summary
    pfam02312
    Location:1 → 162
    CBF_beta; Core binding factor beta subunit

  5. XM_021467589.2 → XP_021323264.1  core-binding factor subunit beta isoform X4

    UniProtKB/TrEMBL
    A0A0B4PIS7, A0A8M3AJI5
    Related
    ENSDARP00000142061.1, ENSDART00000173131.2
    Conserved Domains (1) summary
    pfam02312
    Location:1 → 162
    CBF_beta; Core binding factor beta subunit

  6. XM_005159047.5 → XP_005159104.1  core-binding factor subunit beta isoform X2

    UniProtKB/TrEMBL
    A0A8M2B5H7
    Conserved Domains (1) summary
    pfam02312
    Location:1 → 162
    CBF_beta; Core binding factor beta subunit

  7. XM_005159049.5 → XP_005159106.1  core-binding factor subunit beta isoform X7

    See identical proteins and their annotated locations for XP_005159106.1

    UniProtKB/TrEMBL
    A0A0B4P506, A0A8M9PLY2
    Related
    ENSDARP00000142316.1, ENSDART00000172995.2
    Conserved Domains (1) summary
    pfam02312
    Location:1 → 162
    CBF_beta; Core binding factor beta subunit

  8. XM_021467591.2 → XP_021323266.1  core-binding factor subunit beta isoform X7

    UniProtKB/TrEMBL
    A0A0B4P506, A0A8M9PLY2
    Conserved Domains (1) summary
    pfam02312
    Location:1 → 162
    CBF_beta; Core binding factor beta subunit

  9. XM_068214724.1 → XP_068070825.1  core-binding factor subunit beta isoform X6

  10. XM_021467590.2 → XP_021323265.1  core-binding factor subunit beta isoform X5

    UniProtKB/TrEMBL
    A0A8M9PQ04
    Conserved Domains (1) summary
    pfam02312
    Location:1 → 162
    CBF_beta; Core binding factor beta subunit

RNA

  1. XR_002455999.2 RNA Sequence

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395026.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    184880..201412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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